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- Tatovic, D, et al.
(author)
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Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in type 1 diabetes
- 2022
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In: Immunotherapy Advances. - : Oxford University Press (OUP). - 2732-4303. ; 2:1
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Journal article (peer-reviewed)abstract
- Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop autoimmune β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known for its positive safety profile) was conjugated to ultrasmall gold nanoparticles (GNPs), an attractive drug delivery platform due to the potential anti-inflammatory properties of gold. We hypothesised that microneedle intradermal delivery of C19-A3 GNP may improve peptide pharmacokinetics and induce tolerogenic immunomodulation and proceeded to evaluate its safety and feasibility in a first-in-human trial. Allowing for the limitation of the small number of participants, intradermal administration of C19-A3 GNP appears safe and well tolerated in participants with type 1 diabetes. The associated prolonged skin retention of C19-A3 GNP after intradermal administration offers a number of possibilities to enhance its tolerogenic potential, which should be explored in future studies.
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| 3. |
- Mishra, Deepak, 1990-, et al.
(author)
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Charging time characterization for wireless RF energy transfer
- 2015
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In: IEEE Transactions on Circuits and Systems - II - Express Briefs. - : Institute of Electrical and Electronics Engineers (IEEE). - 1549-7747 .- 1558-3791. ; 62:4, s. 362-366
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Journal article (peer-reviewed)abstract
- Wireless energy transfer to the onboard energy storage element using dedicated radio frequency (RF) energy source has the potential to provide sustained network operations by recharging the sensor nodes on demand. To determine the efficiency of RF energy transfer (RFET), characterization of recharging process is needed. Different from classical capacitor-charging operation, the incident RF waves provide constant power (instead of constant voltage or current) to the storage element, which requires a new theoretical framework for analyzing the charging behavior. This work develops the charging equation for replenishing an energy-depleted storage element by RFET. Since the remaining energy on a sensor node is a random parameter, the RF charging time distribution for a given residual voltage distribution is also derived. The analytical model is validated through hardware experiments and simulations.
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| 4. |
- Powers, S. M., et al.
(author)
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Global Opportunities to Increase Agricultural Independence Through Phosphorus Recycling
- 2019
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In: Earth's Future. - : AMER GEOPHYSICAL UNION. - 2328-4277. ; 7:4, s. 370-383
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Journal article (peer-reviewed)abstract
- Food production hinges largely upon access to phosphorus (P) fertilizer. Most fertilizer P used in the global agricultural system comes from mining of nonrenewable phosphate rock deposits located within few countries. However, P contained in livestock manure or urban wastes represents a recyclable source of P. To inform development of P recycling technologies and policies, we examined subnational, national, and global spatial patterns for two intersections of land use affording high P recycling potential: (a) manure-rich cultivated areas and (b) populous cultivated areas. In turn, we examined overlap between P recycling potential and nation-level P fertilizer import dependency. Populous cultivated areas were less abundant globally than manure-rich cultivated areas, reflecting greater segregation between crops and people compared to crops and livestock, especially in the Americas. Based on a global hexagonal grid (290-km(2) grid cell area), disproportionately large shares of subnational hot spots for P recycling potential occurred in India, China, Southeast Asia, Europe, and parts of Africa. Outside of China, most of the remaining manure-rich or pulous cultivated areas occurred within nations that had relatively high imports of P fertilizer (net P import:consumption ratios >= 0.4) or substantial increases in fertilizer demand between the 2000s (2002-2006) and 2010s (2010-2014). Manure-rich cultivated grid cells (those above the 75th percentiles for both manure and cropland extent) represented 12% of the global grid after excluding cropless cells. Annually, the global sum of animal manure P was at least 5 times that contained in human excreta, and among cultivated cells the ratio was frequently higher (median = 8.9). The abundance of potential P recycling hot spots within nations that have depended on fertilizer imports or experienced rising fertilizer demand could prove useful for developing local P sources and maintaining agricultural independence.
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