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Subtype-specific ge...
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.
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Barretina, Jordi (author)
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Taylor, Barry S (author)
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Banerji, Shantanu (author)
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Ramos, Alexis H (author)
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Lagos-Quintana, Mariana (author)
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Decarolis, Penelope L (author)
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Shah, Kinjal (author)
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Socci, Nicholas D (author)
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Weir, Barbara A (author)
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Ho, Alan (author)
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Chiang, Derek Y (author)
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Reva, Boris (author)
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Mermel, Craig H (author)
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Getz, Gad (author)
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Antipin, Yevgenyi (author)
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Beroukhim, Rameen (author)
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Major, John E (author)
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Hatton, Charles (author)
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Nicoletti, Richard (author)
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Hanna, Megan (author)
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Sharpe, Ted (author)
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Fennell, Tim J (author)
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Cibulskis, Kristian (author)
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Onofrio, Robert C (author)
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Saito, Tsuyoshi (author)
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Shukla, Neerav (author)
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Lau, Christopher (author)
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- Nelander, Sven, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Silver, Serena J (author)
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Sougnez, Carrie (author)
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Viale, Agnes (author)
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Winckler, Wendy (author)
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Maki, Robert G (author)
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Garraway, Levi A (author)
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Lash, Alex (author)
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Greulich, Heidi (author)
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Root, David E (author)
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Sellers, William R (author)
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Schwartz, Gary K (author)
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Antonescu, Cristina R (author)
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Lander, Eric S (author)
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Varmus, Harold E (author)
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Ladanyi, Marc (author)
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Sander, Chris (author)
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Meyerson, Matthew (author)
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Singer, Samuel (author)
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(creator_code:org_t)
- 2010-07-04
- 2010
- English.
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:8, s. 715-21
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Soft-tissue sarcomas, which result in approximately 10,700 diagnoses and 3,800 deaths per year in the United States, show remarkable histologic diversity, with more than 50 recognized subtypes. However, knowledge of their genomic alterations is limited. We describe an integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes. Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8% of pleomorphic liposarcomas) and PIK3CA (18% of myxoid/round-cell liposarcomas, or MRCs). PIK3CA mutations in MRCs were associated with Akt activation and poor clinical outcomes. In myxofibrosarcomas and pleomorphic liposarcomas, we found both point mutations and genomic deletions affecting the tumor suppressor NF1. Finally, we found that short hairpin RNA (shRNA)-based knockdown of several genes amplified in dedifferentiated liposarcoma, including CDK4 and YEATS4, decreased cell proliferation. Our study yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Keyword
- Adult
- Aged
- Female
- Genes
- Tumor Suppressor
- Genome
- Histiocytoma
- Malignant Fibrous
- genetics
- Humans
- Liposarcoma
- genetics
- metabolism
- pathology
- Male
- Middle Aged
- Mutation
- Sarcoma
- genetics
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Barretina, Jordi
-
Taylor, Barry S
-
Banerji, Shantan ...
-
Ramos, Alexis H
-
Lagos-Quintana, ...
-
Decarolis, Penel ...
-
show more...
-
Shah, Kinjal
-
Socci, Nicholas ...
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Weir, Barbara A
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Ho, Alan
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Chiang, Derek Y
-
Reva, Boris
-
Mermel, Craig H
-
Getz, Gad
-
Antipin, Yevgeny ...
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Beroukhim, Ramee ...
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Major, John E
-
Hatton, Charles
-
Nicoletti, Richa ...
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Hanna, Megan
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Sharpe, Ted
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Fennell, Tim J
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Cibulskis, Krist ...
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Onofrio, Robert ...
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Saito, Tsuyoshi
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Shukla, Neerav
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Lau, Christopher
-
Nelander, Sven, ...
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Silver, Serena J
-
Sougnez, Carrie
-
Viale, Agnes
-
Winckler, Wendy
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Maki, Robert G
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Garraway, Levi A
-
Lash, Alex
-
Greulich, Heidi
-
Root, David E
-
Sellers, William ...
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Schwartz, Gary K
-
Antonescu, Crist ...
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Lander, Eric S
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Varmus, Harold E
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Ladanyi, Marc
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Sander, Chris
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Meyerson, Matthe ...
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Singer, Samuel
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Developmental Bi ...
- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg