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- Morel, Chantal M., et al.
(author)
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A one health framework to estimate the cost of antimicrobial resistance
- 2020
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In: Antimicrobial Resistance and Infection Control. - : Springer Science and Business Media LLC. - 2047-2994. ; 9:1
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Journal article (peer-reviewed)abstract
- Objectives/purpose: The costs attributable to antimicrobial resistance (AMR) remain theoretical and largely unspecified. Current figures fail to capture the full health and economic burden caused by AMR across human, animal, and environmental health; historically many studies have considered only direct costs associated with human infection from a hospital perspective, primarily from high-income countries. The Global Antimicrobial Resistance Platform for ONE-Burden Estimates (GAP-ONeuro) network has developed a framework to help guide AMR costing exercises in any part of the world as a first step towards more comprehensive analyses for comparing AMR interventions at the local level as well as more harmonized analyses for quantifying the full economic burden attributable to AMR at the global level.Methods: GAP-ONeuro (funded under the JPIAMR 8th call (Virtual Research Institute) is composed of 19 international networks and institutions active in the field of AMR. For this project, the Network operated by means of Delphi rounds, teleconferences and face-to-face meetings. The resulting costing framework takes a bottom-up approach to incorporate all relevant costs imposed by an AMR bacterial microbe in a patient, in an animal, or in the environment up through to the societal level.Results: The framework itemizes the epidemiological data as well as the direct and indirect cost components needed to build a realistic cost picture for AMR. While the framework lists a large number of relevant pathogens for which this framework could be used to explore the costs, the framework is sufficiently generic to facilitate the costing of other resistant pathogens, including those of other aetiologies.Conclusion: In order to conduct cost-effectiveness analyses to choose amongst different AMR-related interventions at local level, the costing of AMR should be done according to local epidemiological priorities and local health service norms. Yet the use of a common framework across settings allows for the results of such studies to contribute to cumulative estimates that can serve as the basis of broader policy decisions at the international level such as how to steer R&D funding and how to prioritize AMR amongst other issues. Indeed, it is only by building a realistic cost picture that we can make informed decisions on how best to tackle major health threats.
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- Kalinova, V, et al.
(author)
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Investigating the link between inner gravitational potential and star-formation quenching in CALIFA galaxies
- 2022
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 665
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Journal article (peer-reviewed)abstract
- It has been suggested that gravitational potential can have a significant role in suppressing star formation in nearby galaxies. To establish observational constraints on this scenario, we investigated the connection between the dynamics - taking the circular velocity curves (CVCs) as a proxy for the inner gravitational potential - and star formation quenching in 215 non-active galaxies across the Hubble sequence from the Calar Alto Legacy Integral Field Area (CALIFA) survey. Our results show that galaxies with similar CVCs tend to have a certain star-formation quenching pattern. To explore these findings in more details, we constructed kiloparsec (kpc) resolved relations of the equivalent width of the H alpha (W-H alpha) versus the amplitude (V-c) and shape (beta = dln V-c/d ln R) of the circular velocity at given radii. We find that the W-H alpha V-c is a declining relationship, where the retired regions of the galaxies (the ones with W-H alpha values of below 3 angstrom) tend to have higher V-c. Concurrently, W-H alpha-beta is a bimodal relationship, which is characterised by two peaks: concentration of the star forming regions at a positive beta (rising CVC) and a second concentration of the retired regions with a negative beta (declining CVC). Our results show that both the amplitude of the CVC - driven by the mass of the galaxies - and its shape - which reflects the internal structure of the galaxies - play an important role in the quenching history of a galaxy.
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