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- Suino, G., et al.
(författare)
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Simulations of Mini-EUSO observations of UV phenomena in the atmosphere
- 2017
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Ingår i: Proceedings of Science. - Trieste, Italy : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- The Mini-EUSO instrument is an UV telescope to be placed aboard the International Space Station (ISS) in the framework of the JEM-EUSO project. Mini-EUSO will map the Earth in the UV range (300-400 nm) with a spatial resolution of 5 km and a temporal resolution of 2.5 μs. Therefore, Mini-EUSO offers an excellent opportunity to study a variety of physics phenomena such as transient luminous events and meteors, as well as searching for strange quark matter and test the detection of space debris. Mini-EUSO will serve also as a pathfinder for the study of Extreme Energy Cosmic Rays from space. A review on the expected performance of Mini-EUSO in detecting a variety of physical phenomena simulated with the EUSO Simulation and Analysis Framework (ESAF) package is described.
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- Vanzetto, S, et al.
(författare)
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Epigenetic modulation in obsessive-compulsive disorder: Methylation and hydroxymethylation of the bdnf gene exon I promoter
- 2021
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Ingår i: EUROPEAN PSYCHIATRY. - : Royal College of Psychiatrists. - 0924-9338 .- 1778-3585. ; 64, s. S124-S124
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Several evidence recognizes Brain Derived Neurotrophic Factor (BDNF) as a promising biomarker in the pathophysiology of psychiatric disorders, including Obsessive-Compulsive Disorder (OCD), considering the involvement of epigenetic regulation in BDNF altered expression.ObjectivesThis study aims to investigate, in a sample of OCD patients, the epigenetic modulation in terms of levels of methylation and hydroxymethylation on the BDNF gene exon I promoter.MethodsFifty OCD patients, recruited from Psychiatry Unit 2, Sacco University Hospital in Milan and fifty healthy controls, comparable by age and gender. Saliva samples were collected by oral swab and epigenetic analysis were performed at the University of Teramo. Statistical analyses were performed with t test with Bonferroni correction.ResultsData analysis showed a significant decrease in 5-methyl cytosine levels (5mC) (mean OCD: 1.221%; mean CTRL: 1.784%; p < 0.001) and a significant increase in 5-Hydroxy-methyl cytosine levels (5hmC) (mean OCD: 1.018%; mean CTRL: 0.527% p< 0.0001) in BDNF gene exon I promoter of OCD patients compared to controls. Regarding 5mC of site 3 and 5hmC of site 1 and 2 of the exon I promoter CpG islands, no statistical significance was found.ConclusionsPresent results showed significant differences in epigenetic modulation of BDNF gene, which might not be univocally interpreted. They could represent an intrinsic OCD characteristic or the effect of antidepressant drugs, assumed by all recruited patients. Further studies, comparing OCD subjects in treatment vs drug-free, are necessary to define BDNF epigenetic modulation role and its possible use as biomarker in the characterization of OCD.DisclosureNo significant relationships.
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