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Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation

Mälarstig, Anders (author)
Pfizer Worldwide Res Dev & Med, Stockholm, Sweden
Grassmann, Felix (author)
Karolinska Institutet
Dahl, Leo, 1995- (author)
KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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Dimitriou, Marios (author)
Karolinska Institutet
McLeod, Dianna (author)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
Gabrielson, Marike (author)
Karolinska Institutet
Smith-Byrne, Karl (author)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England
Thomas, Cecilia Engel (author)
KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
Huang, Tzu Hsuan (author)
Pfizer Inc, Canc Immunol Discovery, San Diego, CA USA
Forsberg, Simon K.G. (author)
Olink Prote AB, Uppsala, Sweden
Eriksson, Per (author)
Olink Prote AB, Uppsala, Sweden
Ulfstedt, Mikael (author)
Olink Prote AB, Uppsala, Sweden
Johansson, Mattias (author)
Int Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France
Sokolov, Aleksandr V. (author)
Uppsala universitet,Funktionell farmakologi och neurovetenskap
Schiöth, Helgi B. (author)
Uppsala universitet,Funktionell farmakologi och neurovetenskap
Hall, Per (author)
Karolinska Institutet
Schwenk, Jochen M. (author)
KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
Czene, Kamila (author)
Karolinska Institutet
Hedman, Åsa K. (author)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; Pfizer Worldwide Res Dev & Med, Stockholm, Sweden
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 (creator_code:org_t)
Springer Nature, 2023
2023
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
Related links:
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https://uu.diva-port... (primary) (Raw object)
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Biomarkers for early detection of breast cancer may complement population screening approaches to enable earlier and more precise treatment. The blood proteome is an important source for biomarker discovery but so far, few proteins have been identified with breast cancer risk. Here, we measure 2929 unique proteins in plasma from 598 women selected from the Karolinska Mammography Project to explore the association between protein levels, clinical characteristics, and gene variants, and to identify proteins with a causal role in breast cancer. We present 812 cis-acting protein quantitative trait loci for 737 proteins which are used as instruments in Mendelian randomisation analyses of breast cancer risk. Of those, we present five proteins (CD160, DNPH1, LAYN, LRRC37A2 and TLR1) that show a potential causal role in breast cancer risk with confirmatory results in independent cohorts. Our study suggests that these proteins should be further explored as biomarkers and potential drug targets in breast cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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