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Does parity matter ...
Does parity matter in women's risk of dementia? A COSMIC collaboration cohort study
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Bae, J. B. (author)
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Lipnicki, D. M. (author)
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Han, J. W. (author)
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show more...
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Sachdev, P. S. (author)
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Kim, T. H. (author)
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Kwak, K. P. (author)
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Kim, B. J. (author)
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Kim, S. G. (author)
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Kim, J. L. (author)
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Moon, S. W. (author)
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Park, J. H. (author)
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Ryu, S. H. (author)
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Youn, J. C. (author)
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Lee, D. Y. (author)
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Lee, D. W. (author)
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Lee, S. B. (author)
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Lee, J. J. (author)
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Jhoo, J. H. (author)
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Llibre-Rodriguez, J. J. (author)
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Llibre-Guerra, J. J. (author)
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Valhuerdi-Cepero, A. J. (author)
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Ritchie, K. (author)
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Ancelin, M. L. (author)
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Carriere, I. (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Najar, Jenna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Rydberg Sterner, Therese (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Scarmeas, N. (author)
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Yannakoulia, M. (author)
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Dardiotis, E. (author)
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Meguro, K. (author)
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Kasai, M. (author)
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Nakamura, K. (author)
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Riedel-Heller, S. (author)
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Roehr, S. (author)
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Pabst, A. (author)
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van Boxtel, M. (author)
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Kohler, S. (author)
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Ding, D. (author)
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Zhao, Q. H. (author)
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Liang, X. N. (author)
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Scazufca, M. (author)
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Lobo, A. (author)
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De-la-Camara, C. (author)
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Lobo, E. (author)
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Kim, K. W. (author)
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Cohort Studies Memory Int, Consorti (author)
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(creator_code:org_t)
- 2020-08-05
- 2020
- English.
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In: Bmc Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 18:1
- Related links:
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https://bmcmedicine....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype. Results Across all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia. Conclusion Parity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Dementia
- Alzheimer's disease
- Risk factors
- Parity
- Women
- alzheimers-disease
- pregnancy
- estradiol
- health
- atherosclerosis
- association
- population
- prevalence
- premature
- profiles
- General & Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bae, J. B.
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Lipnicki, D. M.
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Han, J. W.
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Sachdev, P. S.
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Kim, T. H.
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Kwak, K. P.
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show more...
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Kim, B. J.
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Kim, S. G.
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Kim, J. L.
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Moon, S. W.
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Park, J. H.
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Ryu, S. H.
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Youn, J. C.
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Lee, D. Y.
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Lee, D. W.
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Lee, S. B.
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Lee, J. J.
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Jhoo, J. H.
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Llibre-Rodriguez ...
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Llibre-Guerra, J ...
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Valhuerdi-Cepero ...
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Ritchie, K.
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Ancelin, M. L.
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Carriere, I.
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Skoog, Ingmar, 1 ...
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Najar, Jenna
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Rydberg Sterner, ...
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Scarmeas, N.
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Yannakoulia, M.
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Dardiotis, E.
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Meguro, K.
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Kasai, M.
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Nakamura, K.
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Riedel-Heller, S ...
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Roehr, S.
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Pabst, A.
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van Boxtel, M.
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Kohler, S.
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Ding, D.
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Zhao, Q. H.
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Liang, X. N.
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Scazufca, M.
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Lobo, A.
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De-la-Camara, C.
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Lobo, E.
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Kim, K. W.
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Cohort Studies M ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Bmc Medicine
- By the university
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University of Gothenburg