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Effect of exercise ...
Effect of exercise training on insulin sensitivity, hyperinsulinemia and ectopic fat in black South African women : a randomized controlled trial
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Fortuin-de Smidt, Melony C. (författare)
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Mendham, Amy E. (författare)
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- Hauksson, Jon (författare)
- Umeå universitet,Radiofysik,Centrum för medicinsk teknik och fysik (CMTF)
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Hakim, Olah (författare)
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Stefanovski, Darko (författare)
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Clamp, Louise (författare)
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Phiri, Lindokuhle (författare)
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Swart, Jeroen (författare)
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Goff, Louise M. (författare)
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Micklesfield, Lisa K. (författare)
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Kahn, Steven E. (författare)
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- Olsson, Tommy (författare)
- Umeå universitet,Avdelningen för medicin
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Goedecke, Julia H. (författare)
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(creator_code:org_t)
- Bioscientifica, 2020
- 2020
- Engelska.
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 183:1, s. 51-61
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: We investigated the effects of a 12-week exercise intervention on insulin sensitivity (SI) and hyperinsulinemia and associated changes in regional and ectopic fat.Research design and methods: Healthy, black South African women with obesity (mean age 23 ± 3.5 years) and of isiXhosa ancestry were randomised into a 12-week aerobic and resistance exercise training group (n = 23) and a no exercise group (control, n = 22). Pre and post-intervention testing included assessment of SI, insulin response to glucose (AIRg), insulin secretion rate (ISR), hepatic insulin extraction (FEL) and disposition index (DI) (AIRg × SI) (frequently sampled i.v. glucose tolerance test); fat mass and regional adiposity (dual-energy X-ray absorptiometry); hepatic, pancreatic and skeletal muscle fat content and abdominal s.c. and visceral adipose tissue volumes (MRI).Results: Exercise training increased VO2peak (mean ± s.d.: 24.9 ± 2.42 to 27.6 ± 3.39 mL/kg/min, P < 0.001), SI (2.0 (1.2–2.8) to 2.2 (1.5–3.7) (mU/l)−1 min−1, P = 0.005) and DI (median (interquartile range): 6.1 (3.6–7.1) to 6.5 (5.6–9.2) × 103 arbitrary units, P = 0.028), and decreased gynoid fat mass (18.5 ± 1.7 to 18.2 ± 1.6%, P < 0.001) and body weight (84.1 ± 8.7 to 83.3 ± .9.7 kg, P = 0.038). None of these changes were observed in the control group, but body weight increased (P = 0.030). AIRg, ISR and FEL, VAT, SAT and ectopic fat were unaltered after exercise training. The increase in SI and DI were not associated with changes in regional or ectopic fat.Conclusion: Exercise training increased SI independent from changes in hyperinsulinemia and ectopic fat, suggesting that ectopic fat might not be a principal determinant of insulin resistance in this cohort.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Fortuin-de Smidt ...
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Mendham, Amy E.
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Hauksson, Jon
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Hakim, Olah
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Stefanovski, Dar ...
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Clamp, Louise
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Phiri, Lindokuhl ...
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Swart, Jeroen
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Goff, Louise M.
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Micklesfield, Li ...
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Kahn, Steven E.
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Olsson, Tommy
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Goedecke, Julia ...
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