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Plasmonic Nanopores...
Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA
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- Belkin, Maxim (author)
- University of Illinois, IL 61801 USA
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- Chao, Shu-Han (author)
- University of Illinois, IL 61801 USA
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- Jonsson, Magnus (author)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Delft University of Technology, Netherlands
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- Dekker, Cees (author)
- Delft University of Technology, Netherlands
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- Aksimentiev, Aleksei (author)
- University of Illinois, IL 61801 USA
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(creator_code:org_t)
- 2015-10-01
- 2015
- English.
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In: ACS Nano. - : AMER CHEMICAL SOC. - 1936-0851 .- 1936-086X. ; 9:11, s. 10598-10611
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https://doi.org/10.1...
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Abstract
Subject headings
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- With the aim of developing a DNA sequencing methodology, we theoretically examine the feasibility of using nanoplasmonics to control the translocation of a DNA molecule through a solid-state nanopore and to read off sequence information using surface-enhanced Raman spectroscopy. Using molecular dynamics simulations, we show that high-intensity optical hot spots produced by a metallic nanostructure can arrest DNA translocation through a solid-state nanopore, thus providing a physical knob for controlling the DNA speed. Switching the plasmonic field on and off can displace the DNA molecule in discrete steps, sequentially exposing neighboring fragments of a DNA molecule to the pore as well as to the plasmonic hot spot. Surface-enhanced Raman scattering from the exposed DNA fragments contains information about their nucleotide composition, possibly allowing the identification of the nucleotide sequence of a DNA molecule transported through the hot spot. The principles of plasmonic nanopore sequencing can be extended to detection of DNA modifications and RNA characterization.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
Keyword
- nanopore; DNA sequencing; nanoplasmonics; molecular dynamics; plasmonic tweezers
Publication and Content Type
- ref (subject category)
- art (subject category)
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