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Reversal learning r...
Reversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntingtons disease
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- Nickchen, Katharina (author)
- Charite University of Medical Berlin, Germany; Fliedner Klin Berlin, Germany
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- Böhme, Rebecca (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Charite University of Medical Berlin, Germany
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- del Mar Amador, Maria (author)
- Charite University of Medical Berlin, Germany
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- Haelbig, Thomas D. (author)
- Charite University of Medical Berlin, Germany
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- Dehnicke, Katharina (author)
- Charite University of Medical Berlin, Germany; Helios Klinikum Bad Saarow, Germany
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- Panneck, Patricia (author)
- Charite University of Medical Berlin, Germany
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- Behr, Joachim (author)
- Charite University of Medical Berlin, Germany; Medical School Brandenburg, Germany
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- Prass, Konstantin (author)
- Helios Klinikum Bad Saarow, Germany
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- Heinz, Andreas (author)
- Charite University of Medical Berlin, Germany
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- Deserno, Lorenz (author)
- Charite University of Medical Berlin, Germany; Max Planck Institute Human Cognit and Brain Science, Germany
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- Schlagenhauf, Florian (author)
- Charite University of Medical Berlin, Germany; Max Planck Institute Human Cognit and Brain Science, Germany
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- Priller, Josef (author)
- Charite University of Medical Berlin, Germany; BIH, Germany; DZNE, Germany
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(creator_code:org_t)
- 2016-12-05
- 2017
- English.
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In: Brain Imaging and Behavior. - : SPRINGER. - 1931-7557 .- 1931-7565. ; 11:6, s. 1862-1872
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Huntingtons disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging. We studied 24 HD patients without central nervous system (CNS)-active medication and 25 healthy controls. Twenty HD patients and 24 healthy controls were able to complete the task. Computational modeling was used to calculate prediction error values and estimate individual parameters. We observed that gray matter density and prediction error signals during the learning task were related to disease stage. HD patients in advanced disease stages appear to use a less complex strategy in the reversal learning task. In contrast, HD patients in early disease stages show intact encoding of learning signals in the degenerating left ventral striatum. This effect appears to be lost with disease progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Huntingtons disease; Reinforcement learning; Ventral striatum; Gray matter density
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nickchen, Kathar ...
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Böhme, Rebecca
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del Mar Amador, ...
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Haelbig, Thomas ...
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Dehnicke, Kathar ...
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Panneck, Patrici ...
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Behr, Joachim
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Prass, Konstanti ...
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Heinz, Andreas
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Deserno, Lorenz
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Schlagenhauf, Fl ...
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Priller, Josef
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Brain Imaging an ...
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Linköping University