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Sökning: WFRF:(Dick D) > Medicin och hälsovetenskap

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Numrering	Referens	Omslagsbild	Hitta
1.	Bhangu, A, et al. (författare) Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study 2018 Ingår i: The Lancet. Infectious diseases. - : Elsevier. - 1474-4457 .- 1473-3099. ; 18:5, s. 516-525 Tidskriftsartikel (refereegranskat)
2.	Szarek, M, et al. (författare) Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial 2019 Ingår i: Circulation. Cardiovascular quality and outcomes. - : Ovid Technologies (Wolters Kluwer Health). - 1941-7705 .- 1941-7713. ; 12:11, s. e005858- Tidskriftsartikel (refereegranskat)
3.	Ray, KK, et al. (författare) Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 2019 Ingår i: The lancet. Diabetes & endocrinology. - 2213-8595 .- 2213-8587. ; 7:8, s. 618-628 Tidskriftsartikel (refereegranskat)
4.	Jukema, JW, et al. (författare) Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial 2019 Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1167-1176 Tidskriftsartikel (refereegranskat)
5.	Roe, MT, et al. (författare) Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes 2019 Ingår i: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 1524-4539 .- 0009-7322. ; 140:19, s. 1578-1589 Tidskriftsartikel (refereegranskat)
6.	Szarek, M, et al. (författare) Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial 2019 Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 73:4, s. 387-396 Tidskriftsartikel (refereegranskat)
7.	Davies, G., et al. (författare) Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function 2018 Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1 Tidskriftsartikel (refereegranskat)abstract General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
8.	Lee, PH, et al. (författare) Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders 2019 Ingår i: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 179:7, s. 1469- Tidskriftsartikel (refereegranskat)
9.	Bryois, J., et al. (författare) Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease 2020 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493 Tidskriftsartikel (refereegranskat)abstract Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
10.	Kunkle, BW, et al. (författare) Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing 2019 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:3, s. 414- Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (67); forskningsöversikt (3)

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Författare/redaktör: Thompson, Paul M (10); Heinegård, Dick (10); Ching, Christopher R ... (9); Jahanshad, Neda (9); Veltman, Dick J (9); Agartz, Ingrid (8); visa fler...; Westlye, Lars T (8); Stein, Dan J (8); Schmaal, Lianne (8); Herzog, W (8); Ehrlich, Stefan (8); Ricca, V. (8); Franke, Barbara (7); Kaprio, J (7); Andreassen, Ole A (7); Crespo-Facorro, Bene ... (7); Tordesillas-Gutierre ... (7); Giegling, I (7); Wittfeld, Katharina (7); Wright, Margaret J. (7); Fisher, Simon E. (7); Guo, Y (6); Ahmed, H. (6); Davies, R (6); Brouwer, Rachel M (6); Pomarol-Clotet, Edit ... (6); Rujescu, D (6); Janik, M (6); Lee, K (6); Huber, K (6); Müller, C. (6); de Geus, Eco J. C. (6); Martin, Nicholas G. (6); Boomsma, Dorret I. (6); Larsen, J (6); de Silva, HA (6); Sachdev, Perminder S ... (6); Medland, Sarah E (6); Whitaker, J (6); Berti, S (6); de Zubicaray, Greig ... (6); Glahn, David C. (6); Holmes, Avram J. (6); McMahon, Katie L. (6); van Haren, Neeltje E ... (6); Wen, Wei (6); Smoller, Jordan W (6); Uhlmann, Anne (6); Den Braber, Anouk (6); Hoekstra, Pieter J. (6); visa färre...

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