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Sökning: WFRF:(Dmytruk Kostyantyn)

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  • Dzanaeva, Ljubov, et al. (författare)
  • The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae
  • 2020
  • Ingår i: Cell Biology International. - : Wiley. - 1095-8355 .- 1065-6995. ; 44:8, s. 1606-1615
  • Tidskriftsartikel (refereegranskat)abstract
    • Xylose is a second-most abounded sugar after glucose in lignocellulosic hydrolysates and should be efficiently fermented for economically viable second-generation ethanol production. Despite significant progress in metabolic and evolutionary engineering, xylose fermentation rate of recombinant Saccharomyces cerevisiae remains lower than that for glucose. Our recent study demonstrated that peroxisome-deficient cells of yeast Ogataea polymorpha showed a decrease in ethanol production from xylose. In this work, we have studied the role of peroxisomes in xylose alcoholic fermentation in the engineered xylose-utilizing strain of S. cerevisiae. It was shown that peroxisome-less pex3 Delta mutant possessed 1.5-fold decrease of ethanol production from xylose. We hypothesized that peroxisomal catalase Cta1 may have importance for hydrogen peroxide, the important component of reactive oxygen species, detoxification during xylose alcoholic fermentation. It was clearly shown that CTA1 deletion impaired ethanol production from xylose. It was found that enhancing the peroxisome population by modulation the peroxisomal biogenesis by overexpression of PEX34 activates xylose alcoholic fermentation.
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  • Sibirny, Andriy, et al. (författare)
  • Development of the thermotolerant methylotrophic yeast hansenula polymorpha as efficient ethanol producer
  • 2017
  • Ingår i: Yeast Diversity in Human Welfare. - Singapore : Springer Singapore. - 9789811026201 - 9789811026218 ; , s. 257-282
  • Bokkapitel (refereegranskat)abstract
    • Until recently, the methylotrophic yeasts, including Hansenula polymorpha, have not been considered as a potential producer of biofuels, particularly, ethanol from lignocellulosics. However it is already known that the thermotolerant methylotrophic yeast H. polymorpha is capable to ferment xylose, glucose and cellobiose, the main sugars of lignocellulosic hydrolysates, under elevated temperature. These observations allow considering H. polymorpha as a promising organism for high temperature alcoholic fermentation in industrial applications. Although the amount of ethanol produced from xylose by the wild-type strains of H. polymorpha is extremely low, the successful approaches of metabolic engineering and classical selection had been developed during last decade, which permitted to increase ethanol accumulation from xylose 30-fold. The available strains accumulate 12.5 g of ethanol per liter from xylose at 45 °C. In this article, we present published and new approaches and main achievements on metabolic engineering and selection of H. polymorpha for improved producers of ethanol from xylose, starch, xylan, and glycerol, as well as that of strains with increased tolerance to high temperatures and ethanol.
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