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Sökning: WFRF:(Droste M.)

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1.
  • Valassi, E., et al. (författare)
  • High mortality within 90 days of diagnosis in patients with Cushing's syndrome: results from the ERCUSYN registry
  • 2019
  • Ingår i: European Journal of Endocrinology. - 0804-4643. ; 181:5, s. 461-472
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: Patients with Cushing's syndrome (CS) have increased mortality. The aim of this study was to evaluate the causes and time of death in a large cohort of patients with CS and to establish factors associated with increased mortality. Methods: In this cohort study, we analyzed 1564 patients included in the European Registry on CS (ERCUSYN); 1045 (67%) had pituitary-dependent CS, 385 (25%) adrenal-dependent CS, 89 (5%) had an ectopic source and 45 (3%) other causes. The median (IQR) overall follow-up time in ERCUSYN was 2.7 (1.2-5.5) years. Results: Forty-nine patients had died at the time of the analysis; 23 (47%) with pituitary-dependent CS, 6 (12%) with adrenal-dependent CS, 18 (37%) with ectopic CS and two (4%) with CS due to other causes. Of 42 patients whose cause of death was known, 15 (36%) died due to progression of the underlying disease, 13 (31%) due to infections, 7 (17%) due to cardiovascular or cerebrovascular disease and 2 due to pulmonary embolism. The commonest cause of death in patients with pituitary-dependent CS and adrenal-dependent CS were infectious diseases (n = 8) and progression of the underlying tumor (n = 10) in patients with ectopic CS. Patients who had died were older and more often males, and had more frequently muscle weakness, diabetes mellitus and ectopic CS, compared to survivors. Of 49 deceased patients, 22 (45%) died within 90 days from start of treatment and 5 (10%) before any treatment was given. The commonest cause of deaths in these 27 patients were infections (n = 10; 37%). In a regression analysis, age, ectopic CS and active disease were independently associated with overall death before and within 90 days from the start of treatment. Conclusion: Mortality rate was highest in patients with ectopic CS. Infectious diseases the commonest cause of death soon after diagnosis, emphasizing the need for careful vigilance at that time, especially in patients presenting with concomitant diabetes mellitus.
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2.
  • Valassi, E., et al. (författare)
  • Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN
  • 2018
  • Ingår i: Clinical Endocrinology. - 0300-0664. ; 88:6, s. 787-798
  • Tidskriftsartikel (refereegranskat)abstract
    • ObjectiveHypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). MethodsData from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. ResultsAt baseline, HRQoL did not differ between PIT-CS (n=293) and ADR-CS (n=120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 4118 and 44 +/- 20, respectively (P=.7). At long-time follow-up (>1year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 +/- 20 vs 62 +/- 23; P=.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P<.001), and older age at diagnosis with worse total score (P=.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P<.001). ConclusionPIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.
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6.
  • Kadykalo, A. N., et al. (författare)
  • Disentangling ‘ecosystem services’ and ‘nature’s contributions to people’
  • 2019
  • Ingår i: Ecosystems and People. - : Taylor & Francis. - 2639-5908 .- 2639-5916. ; 15:1, s. 269-287
  • Tidskriftsartikel (refereegranskat)abstract
    • People depend on functioning ecosystems, which provide benefits that support human existence and wellbeing. The relationship between people and nature has been experienced and conceptualized in multiple ways. Recently, ecosystem services (ES) concepts have permeated science, government policies, multi-national environmental agreements, and science–policy interfaces. In 2017, the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) introduced a new and closely related concept–Nature’s Contributions to People (NCP). The introduction of NCP has sparked some lively discussion and confusion about the distinguishing characteristics between ES and NCP. In order to clarify their conceptual relation, we identify eleven specific claims about novel elements from the latest NCP literature and analyze how far ES research has already contributed to these corresponding conceptual claims in the existing ES literature. We find a mixed-picture, where on six specific conceptual claims (culture, social sciences and humanities, indigenous and local knowledge, negative contributions of nature, generalizing perspective, non-instrumental values and valuation) NCP does not differ greatly from past ES research, but we also find five conceptual claims (diverse worldviews, context-specific perspective, relational values, fuzzy and fluid reporting categories and groups, inclusive language and framing) where NCP provides novel conceptualizations of people and nature relations.
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7.
  • Lieder, R. M., et al. (författare)
  • From highly to superdeformed shapes : study of Gd-143
  • 2000
  • Ingår i: Nuclear Physics A. - 0375-9474 .- 1873-1554. ; 671:04-jan, s. 52-70
  • Tidskriftsartikel (refereegranskat)abstract
    • A superdeformed band has been discovered in Gd-143 consisting Of 15 transitions. It does not show the band crossing observed in the neighbouring heavier Gd isotopes and it is degenerate with the superdeformed band in Eu-143. In contrast to other degenerate bands at superdeformed shape, the configurations of the bands are quite different here. They result from the exchange of a nu 6(4) with a pi[404]9/2 configuration. In addition, a collective band has been observed which adopts a well-deformed triaxial shape at high spins according to calculations. The transition from highly to superdeformed shapes proceeds via triaxial shapes.
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9.
  • Lieder, E O, et al. (författare)
  • Investigation of lifetimes in quadrupole bands of Gd-142
  • 2008
  • Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer. - 1434-6001. ; 35:2, s. 135-158
  • Tidskriftsartikel (refereegranskat)abstract
    • For a level scheme investigation of Gd-142 an experiment with the gamma -spectrometer EUROBALLIII has been carried out and lifetimes have been measured with EUROBALL IV using the Doppler-shift attenuation method. The high-spin states have been populated in these experiments by means of the(99)Ru(Ti-48, 2p3n) reaction at a beam energy of 240MeV and the Sn-114(S-32, 2p2n) reaction at 160MeV, respectively. Reduced E2 transition probabilities B(E2) were determined for 15 members of four quadrupole bands. For the interpretation of the positive-parity even-spin quadrupole bands, calculations in the cranked Nilsson-Strutinsky as well as interacting boson models have been performed. From the former calculations it was concluded that the high-spin states of the (+ , 0)(1) band in Gd-142 represent a triaxial nucleus rotating around the longest principal axis.
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10.
  • Lieder, R. M., et al. (författare)
  • Development of magnetic rotation in light Gd nuclei; study of Gd-142
  • 2002
  • Ingår i: European Physical Journal A. - 1434-6001 .- 1434-601X. ; 13:3, s. 297-305
  • Tidskriftsartikel (refereegranskat)abstract
    • High-spin states in Gd-142 have been populated by means of the Ru-99(Ti-48, 2p3n) reaction at 2-10 MeV and investigated with the gamma-spectrometer EUROBALL III and the charged-particle detector array ISIS. The features of four dipole bands have been determined and compared with tilted-axis cranking model calculations indicating that they are magnetic rotational bands. A transition from regular to irregular bands has been found approaching N = 82 demonstrating that this is a general phenomenon in nuclei near a double-shell closure.
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