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Association of Long...
Association of Long-Term Diet Quality with Hippocampal Volume : Longitudinal Cohort Study
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- Akbaraly, Tasmine (author)
- PSL Res Univ, Univ Montpellier, MMDN, EPHE, INSERM, U1198, Montpellier, France; UCL, Dept Epidemiol & Publ Hlth, London, England; Hosp & Univ Res Ctr Montpellier, Dept Psychiat, Montpellier, France; Hosp & Univ Res Ctr Montpellier, Autism Resources Ctr, Montpellier, France
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- Sexton, Claire (author)
- Univ Oxford, FMRIB Ctr, Nuffield Dept Clin Neurosci, Oxford, England
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- Zsoldos, Eniko (author)
- Univ Oxford, Dept Psychiat, Neurobiol Ageing Grp, Oxford, England
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- Mahmood, Abda (author)
- Univ Oxford, Dept Psychiat, Neurobiol Ageing Grp, Oxford, England
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- Filippini, Nicola (author)
- Univ Oxford, Dept Psychiat, Neurobiol Ageing Grp, Oxford, England
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- Kerleau, Clarisse (author)
- PSL Res Univ, Univ Montpellier, MMDN, EPHE, INSERM, U1198, Montpellier, France
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- Verdier, Jean-Michel (author)
- PSL Res Univ, Univ Montpellier, MMDN, EPHE, INSERM, U1198, Montpellier, France
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- Virtanen, Marianna (author)
- Uppsala universitet,Folkhälsovetenskap,Public Health Research
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- Gabelle, Audrey (author)
- Univ Montpellier, Memory Resources & Res Ctr Alzheimers Dis & Relat, Dept Neurol, Gui de Chauliac Hosp, INSERM, U1183, Montpellier, France
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- Ebmeier, Klaus (author)
- Univ Oxford, Dept Psychiat, Neurobiol Ageing Grp, Oxford, England
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- Kivimäki, Mika (author)
- UCL, Dept Epidemiol & Publ Hlth, London, England
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: American Journal of Medicine. - : Elsevier BV. - 0002-9343 .- 1555-7162. ; 131:11, s. 1372-1381.e4
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Abstract
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- Background: Diet quality is associated with brain aging outcomes. However, few studies have explored in humans the brain structures potentially affected by long-term diet quality. We examined whether cumulative average of the Alternative Healthy Eating Index 2010 (AHEI-2010) score during adult life (an 11-year exposure period) is associated with hippocampal volume.Methods: Analyses were based on data from 459 participants of the Whitehall II imaging sub-study (mean age [standard deviation] (SD) = 59.6 [5.3] years in 2002-2004, 19.2% women). Multimodal magnetic resonance imaging examination was performed at the end of follow-up (2015-2016). Structural images were acquired using a high-resolution 3-dimensional T1-weighted sequence and processed with Functional Magnetic Resonance Imaging of the Brain Software Library (FSL) tools. An automated model-based segmentation and registration tool was applied to extract hippocampal volumes.Results: Higher AHEI-2010 cumulative average score (reflecting long-term healthy diet quality) was associated with a larger total hippocampal volume. For each 1 SD (SD = 8.7 points) increment in AHEI-2010 score, an increase of 92.5 mm3 (standard error = 42.0 mm3) in total hippocampal volume was observed. This association was independent of sociodemographic factors, smoking habits, physical activity, cardiometabolic health factors, cognitive impairment, and depressive symptoms, and was more pronounced in the left hippocampus than in the right hippocampus. Of the AHEI-2010 components, no or light alcohol consumption was independently associated with larger hippocampal volume.Conclusions: Higher long-term AHEI-2010 scores were associated with larger hippocampal volume. Accounting for the importance of hippocampal structures in several neuropsychiatric diseases, our findings reaffirm the need to consider adherence to healthy dietary recommendation in multi-interventional programs to promote healthy brain aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Alternative Healthy Eating Index
- Dietary indices
- Hippocampal volume
- Older adults
- Prospective study
Publication and Content Type
- ref (subject category)
- art (subject category)
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Akbaraly, Tasmin ...
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Sexton, Claire
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Zsoldos, Eniko
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Mahmood, Abda
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Filippini, Nicol ...
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Kerleau, Clariss ...
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Verdier, Jean-Mi ...
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Virtanen, Marian ...
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Gabelle, Audrey
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Ebmeier, Klaus
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Kivimäki, Mika
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Nutrition and Di ...
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MEDICAL AND HEAL ...
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Uppsala University