Search: WFRF:(Eckel Passow Jeanette E.)
> (2019)
> Schoemaker Minouk J. >
Transcriptome-Wide ...
Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma
-
Atkins, Isabelle (author)
-
Kinnersley, Ben (author)
-
Ostrom, Quinn T. (author)
-
show more...
-
Labreche, Karim (author)
-
Il'yasova, Dora (author)
-
Armstrong, Georgina N. (author)
-
Eckel-Passow, Jeanette E. (author)
-
Schoemaker, Minouk J. (author)
-
Nothen, Markus M. (author)
-
Barnholtz-Sloan, Jill S. (author)
-
Swerdlow, Anthony J. (author)
-
Simon, Matthias (author)
-
Rajaraman, Preetha (author)
-
Chanock, Stephen J. (author)
-
Shildkraut, Joellen (author)
-
Bernstein, Jonine L. (author)
-
Hoffman, Per (author)
-
Jockel, Karl-Heinz (author)
-
Lai, Rose K. (author)
-
Claus, Elizabeth B. (author)
-
Olson, Sara H. (author)
-
Johansen, Christoffer (author)
-
Wrensch, Margaret R. (author)
-
- Melin, Beatrice S. (author)
- Umeå universitet,Onkologi
-
Jenkins, Robert B. (author)
-
Sanson, Marc (author)
-
Bondy, Melissa L. (author)
-
Houlston, Richard S. (author)
-
show less...
-
(creator_code:org_t)
- American Association for Cancer Research, 2019
- 2019
- English.
-
In: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 79:8, s. 2065-2071
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility variants reside in noncoding regions and the causal genes underlying the associations are largely unknown. Here we performed a transcriptome-wide association study to search for novel risk loci and candidate causal genes at known GWAS loci using Genotype-Tissue Expression Project (GTEx) data to predict cis-predicted gene expression in relation to GBM and non-GBM risk in conjunction with GWAS summary statistics on 12,488 glioma cases (6,183 GBM and 5,820 non-GBM) and 18,169 controls. Imposing a Bonferroni-corrected significance level of P < 5.69 x 10(-6), candidate novel risk locus for GBM (mean Z = 4.43; P = 5.68 x 10(-6)). GALNT6 resides at least 55 Mb away from any previously identified glioma risk variant, while all other 30 significantly associated genes were located within 1 Mb of known GWAS-identified loci and were not significant after conditioning on the known GWAS-identified variants. These data identify a novel locus (GALNT6 at 12q13.33) and 30 genes at 12 known glioma risk loci associated with glioma risk, providing further insights into glioma tumorigenesis.Significance: This study identifies new genes associated with glioma risk, increasing understanding of how these tumors develop.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Atkins, Isabelle
-
Kinnersley, Ben
-
Ostrom, Quinn T.
-
Labreche, Karim
-
Il'yasova, Dora
-
Armstrong, Georg ...
-
show more...
-
Eckel-Passow, Je ...
-
Schoemaker, Mino ...
-
Nothen, Markus M ...
-
Barnholtz-Sloan, ...
-
Swerdlow, Anthon ...
-
Simon, Matthias
-
Rajaraman, Preet ...
-
Chanock, Stephen ...
-
Shildkraut, Joel ...
-
Bernstein, Jonin ...
-
Hoffman, Per
-
Jockel, Karl-Hei ...
-
Lai, Rose K.
-
Claus, Elizabeth ...
-
Olson, Sara H.
-
Johansen, Christ ...
-
Wrensch, Margare ...
-
Melin, Beatrice ...
-
Jenkins, Robert ...
-
Sanson, Marc
-
Bondy, Melissa L ...
-
Houlston, Richar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Medical Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Research
- By the university
-
Umeå University