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Sökning: WFRF:(Ekelund M.) > Naturvetenskap

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1.
  • Wang, Z., et al. (författare)
  • Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
  • 2022
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 54:9
  • Tidskriftsartikel (refereegranskat)abstract
    • Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.
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2.
  • Lewis, Cathryn M, et al. (författare)
  • Genome scan meta-analysis of schizophrenia and bipolar disorder, part II : Schizophrenia
  • 2003
  • Ingår i: American Journal of Human Genetics. - 0002-9297 .- 1537-6605. ; 73:1, s. 34-48
  • Tidskriftsartikel (refereegranskat)abstract
    • Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk<.000417). Two aggregate criteria for linkage were also met (clusters of nominally significant P values that did not occur in 1,000 replicates of the entire data set with no linkage present): 12 consecutive bins with both P(AvgRnk) and P(ord)<.05, including regions of chromosomes 5q, 3p, 11q, 6p, 1q, 22q, 8p, 20q, and 14p, and 19 consecutive bins with P(ord)<.05, additionally including regions of chromosomes 16q, 18q, 10p, 15q, 6q, and 17q. There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
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3.
  • Speakman, John R., et al. (författare)
  • Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure
  • 2023
  • Ingår i: Nature Metabolism. - : NATURE PORTFOLIO. - 2522-5812. ; 5:4, s. 579-588
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Obesity is caused by a prolonged positive energy balance(1,2). Whether reduced energy expenditure stemming from reduced activity levels contributes is debated(3,4). Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. In males, adjusted BEE decreased significantly, but in females this did not reach significance. A larger dataset of basal metabolic rate (equivalent to BEE) measurements of 9,912 adults across 163 studies spanning 100 years replicates the decline in BEE in both sexes. We conclude that increasing obesity in the United States/Europe has probably not been fuelled by reduced physical activity leading to lowered TEE. We identify here a decline in adjusted BEE as a previously unrecognized factor.
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4.
  • Lett, Signe, et al. (författare)
  • Can bryophyte groups increase functional resolution in tundra ecosystems?
  • 2022
  • Ingår i: Arctic Science. - Ottawa : Canadian Science Publishing. - 2368-7460. ; 8:3, s. 609-637
  • Tidskriftsartikel (refereegranskat)abstract
    • The relative contribution of bryophytes to plant diversity, primary productivity, and ecosystem functioning increases towards colder climates. Bryophytes respond to environmental changes at the species level, but because bryophyte species are relatively difficult to identify, they are often lumped into one functional group. Consequently, bryophyte function remains poorly resolved. Here, we explore how higher resolution of bryophyte functional diversity can be encouraged and implemented in tundra ecological studies. We briefly review previous bryophyte functional classifications and the roles of bryophytes in tundra ecosystems and their susceptibility to environmental change. Based on shoot morphology and colony organization, we then propose twelve easily distinguishable bryophyte functional groups. To illustrate how bryophyte functional groups can help elucidate variation in bryophyte effects and responses, we compiled existing data on water holding capacity, a key bryophyte trait. Although plant functional groups can mask potentially high interspecific and intraspecific variability, we found better separation of bryophyte functional group means compared with previous grouping systems regarding water holding capacity. This suggests that our bryophyte functional groups truly represent variation in the functional roles of bryophytes in tundra ecosystems. Lastly, we provide recommendations to improve the monitoring of bryophyte community changes in tundra study sites.
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5.
  • Hansson, P, et al. (författare)
  • Hepatic lipase activity increases after liver denervation in the rat
  • 1985
  • Ingår i: Biochimica et Biophysica Acta. - 0006-3002. ; 833:2, s. 351-353
  • Tidskriftsartikel (refereegranskat)abstract
    • We have investigated the effects of hilar denervation of rat liver upon the activity of hepatic lipase determined in tissue extracts. Denervated animals had an enzyme activity of 7.89 +/- 0.37 mU/mg protein, compared to 6.45 +/- 0.43 in sham-operated controls (mean +/- S.E.; P less than 0.05). We conclude that hepatic innervation may contribute to the regulation of hepatic lipase activity.
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6.
  • Eriksson, Patrick, 1964, et al. (författare)
  • A general database of hydrometeor single scattering properties at microwave and sub-millimetre wavelengths
  • 2018
  • Ingår i: Earth System Science Data. - : Copernicus GmbH. - 1866-3516 .- 1866-3508. ; 10:3, s. 1301-1326
  • Tidskriftsartikel (refereegranskat)abstract
    • A main limitation today in simulations and inversions of microwave observations of ice hydrometeors (cloud ice, snow, hail, etc.) is the lack of data describing the interaction between electromagnetic waves and the particles. To improve the situation, the development of a comprehensive dataset of such scattering properties has been started. The database aims at giving a broad coverage in both frequency (1 to 886 GHz) and temperature (190 to 270 K), to support both passive and active current and planned measurements, and to provide data corresponding to the full Stokes vector. This first version of the database is restricted to totally random particle orientation. Data for 34 particle sets, i.e. habits, have been generated. About 17 of the habits can be classified as single crystals, three habits can be seen as heavily rimed particles, and the remaining habits are aggregates of different types, e.g. snow and hail. The particle sizes considered vary between the habits, but maximum diameters of 10 and 20 mm are typical values for the largest single crystal and aggregate particles, respectively, and the number of sizes per habit is at least 30. Particles containing liquid water are also inside the scope of the database, but this phase of water is so far only represented by a liquid sphere habit. The database is built upon the netCDF4 file format. Interfaces to browse, extract and convert data for selected radiative transfer models are provided in MATLAB and Python. The database and associated tools are publicly available from Zenodo (https://doi.org/10.5281/zenodo.1175572, Ekelund et al., 2018b), and https://doi.org/10.5281/zenodo.1175588, Mendrok et al., 2018, respectively). Planned extensions include non-spherical raindrops, melting particles and a second orientation case that can be denoted as azimuthally random.
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7.
  • Magnusson, Kerstin, 1957, et al. (författare)
  • Contamination and correlation with toxicity of sediment samples from the Skiagerrak and Kattegat
  • 1996
  • Ingår i: Journal of Sea Research. - 1385-1101. ; 35:1-3, s. 223-234
  • Tidskriftsartikel (refereegranskat)abstract
    • The pollution state in the Skagerrak and Kattegat was investigated by determination of pollutant concentrations and toxicity of sediment samples from 11 stations in the area. A comparison was made with the sediment from a reference site near the Faroe Islands. Polycyclic aromatic hydrocarbons (PAH) and organochlorines were determined in whole sediment and heavy metals and ammonia were analysed in filtered pore water. Toxicity was bioassayed in whole sediment with Nitocra spinipes and Daphnia magna, in pore water with Mytilus edulis larvae and in solvent extracts from sediment with tests measuring etoxyresorufin-O-deethylase (EROD) activity in Oncorhyncus mykiss and rate of denitrification. Sites close to Goteborg and in an area from the Oslo fjord to the Norwegian Trench were most polluted. Sediment from the Faroe Islands was least polluted and also least toxic. Multivariate statistical analysis indicates that the different tests were sensitive to different kinds of pollutants. Effects on mussel larvae correlated strongest with the occurrence of ammonia, manganese, cadmium and PAHs, Nitocra with alpha-hexachlorocyclohexane (HCH) and p,p'-DDD, Daphnia with arsenic and gamma-HCH, fish EROD activity with benzo[ghi]perylene and unknown compounds associated with organic carbon, and denitrification with chlordanes, dieldrin and a few PAHs. The results indicate that sampling sites close to Goteborg are so polluted that harmful effects on the ecosystem probably occur.
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8.
  • Pfreundschuh, Simon, 1989, et al. (författare)
  • Synergistic radar and radiometer retrievals of ice hydrometeors
  • 2020
  • Ingår i: Atmospheric Measurement Techniques. - : Copernicus GmbH. - 1867-1381 .- 1867-8548. ; 13:8, s. 4219-4245
  • Tidskriftsartikel (refereegranskat)abstract
    • Remote sensing observations at sub-millimeter wavelengths provide higher sensitivity to small hydrometeors and low water content than observations at millimeter wavelengths, which are traditionally used to observe clouds and precipitation. They are employed increasingly in field campaigns to study cloud microphysics and will be integrated into the global meteorological observing system to measure the global distribution of ice in the atmosphere with the launch of the Ice Cloud Imager (ICI) radiometer on board the second generation of European operational meteorological satellites (Metop-SG). Observations at these novel wavelengths provide valuable information not only on their own but also in combination with complementary observations at other wavelengths. This study investigates the potential of combining passive sub-millimeter radiometer observations with a hypothetical W-band cloud radar for the retrieval of frozen hydrometeors. An idealized cloud model is used to investigate the information content of the combined observations and establish their capacity to constrain the microphysical properties of ice hydrometeors. A synergistic retrieval algorithm for airborne observations is proposed and applied to simulated observations from a cloud-resolving model. Results from the synergistic retrieval are compared to equivalent radar- and passive-only implementations in order to assess the benefits of the synergistic sensor configuration. The impact of the assumed ice particle shape on the retrieval results is assessed for all retrieval implementations. We find that the combined observations better constrain the microphysical properties of ice hydrometeors, which reduces uncertainties in retrieved ice water content and particle number concentrations for suitable choices of the ice particle model. Analysis of the retrieval information content shows that, although the radar contributes the largest part of the information in the combined retrieval, the radiometer observations provide complementary information over a wide range of atmospheric states. Furthermore, the combined observations yield slightly improved retrievals of liquid cloud water in mixed-phase clouds, pointing towards another potential application of combined radar-radiometer observations.
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9.
  • Granmo, Åke, 1943, et al. (författare)
  • Effects of antifouling paint components (TBTO, copper and triazine) on the early development of embryos in cod (Gadus morhua L.)
  • 2002
  • Ingår i: Marine Pollution Bulletin. - 0025-326X. ; 44:10, s. 1142-1148
  • Tidskriftsartikel (refereegranskat)abstract
    • To assess the risk of antifoulant use to the commercially important cod (Gudus morphua L.). fertilised cod eggs were exposed to triazine, copper and TBTO singly or combined in laboratory tests with running seawater. :fit the highest tested concentrations ( I 1.5 mug Cu l(-1); 5 mug TBTO l(-1)) larval mortality was increased. The highest concentration of triazine ( () ye I) did not cause any significant mortality. Fertilised eggs that had been exposed to all the three chemicals singly for five days shroud a higher buoyancy than the controls. No synergistic or antagonistic effects were indicated. Embryos/larvae exposed to 0.004-0.8 mug TBTO l(-1) did not show any changed respiration compared to the controls after hatching. It is concluded that existing known field concentrations of the three antifoulants are hardly expected to cause detectable effects on fish embryonic/larval development. (C) 2002 Elsevier Science Ltd. All rights reserved.
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10.
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