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- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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- Davidsson, Paul, et al.
(författare)
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Elis : An Open Platform for Mobile Energy Efficiency Services in Buildings
- 2019
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Ingår i: Sustainability. - : MDPI. - 2071-1050. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- The recent years have witnessed an enormous growth of mobile services for energy management in buildings. However, these solutions are often proprietary, non-interoperable, and handle only a limited function, such as lighting, ventilation, or heating. To address these issues, we have developed an open platform that is an integrated energy management solution for buildings. It includes an ecosystem of mobile services and open APIs as well as protocols for the development of new services and products. Moreover, it has an adapter layer that enables the platform to interoperate with any building management system (BMS) or individual device. Thus, the platform makes it possible for third-party developers to produce mobile energy efficiency applications that will work independently of which BMS and devices are used in the building. To validate the platform, a number of services have been implemented and evaluated in existing buildings. This has been done in cooperation with energy companies and property owners, together with the residents and other users of the buildings. The platform, which we call Elis, has been made available as open source software under an MIT license. View Full-Text
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- Eklund, Lina, et al.
(författare)
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Using geographical information systems to analyse accessibility to health services in the West Bank, Occupied Palestinian Territory
- 2012
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Ingår i: Eastern Mediterranean Health Journal. - 1020-3397. ; 18:8, s. 796-802
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Tidskriftsartikel (refereegranskat)abstract
- Abstract in UndeterminedAccessibility to adequate health services is a basic human right. Israeli road blocks and checkpoints inhibit access to health care for the Palestinian population. While other studies have dealt with the impact of the barriers, few are based on actual measurements of transport times between locations. Geographical information systems (GIS) and network analysis were used to generate different estimations of accessibility based on the existing road network and transport barriers. The population negatively affected were mainly people living outside urban centres and in governorates with no general hospital. Quantitative measurements using GIS can be used to confirm qualitative studies based on interviews and questionnaires and improve the understanding of the results. Working with a spatial analysis tool also helps to pinpoint weaknesses in the current infrastructure, thus improving the efficiency of future investments to improve health care in the West Bank.
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