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Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
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- Petursdottir, Dagbjort H. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Nordlander, Sofia (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- Qazi, Khaleda Rahman (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Arrhenius Labs Nat Sci, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
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- (creator_code:org_t)
- 2017-12-01
- 2017
- English.
- In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The intestinal microbiota influences immune maturation during childhood, and is implicated in early-life allergy development. However, to directly study intestinal microbes and gut immune responses in infants is difficult. To investigate how different types of early-life gut microbiota affect immune development, we collected fecal samples from children with different allergic heredity (AH) and inoculated germ-free mice. Immune responses and microbiota composition were evaluated in the offspring of these mice. Microbial composition in the small intestine, the cecum and the colon were determined by 16S rRNA sequencing. The intestinal microbiota differed markedly between the groups of mice, but only exposure to microbiota associated with AH and known future allergy in children resulted in a T helper 17 (Th17)-signature, both systemically and in the gut mucosa in the mouse offspring. These Th17 responses could be signs of a particular microbiota and a shift in immune development, ultimately resulting in an increased risk of allergy.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- infant microbiota
- allergic heredity
- immune development
- germ-free
- T helper 17-responsesIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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