| 1. |
- Lind, Lars, et al.
(författare)
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Obesity is associated with coronary artery stenosis independently of metabolic risk factors : the population-based SCAPIS study
- 2022
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 362, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Background and aims: Previous studies reported divergent results on whether metabolically healthy obesity is associated with increased coronary artery calcium and carotid plaques. We investigated this in a cross-sectional fashion in a large, well-defined, middle-aged population using coronary CT angiography (CCTA) and carotid ultrasound. Methods: In the SCAPIS study (50–65 years, 51% female), CCTA and carotid artery ultrasound were performed in 23,674 individuals without clinical atherosclerotic disease. These subjects were divided into six groups according to BMI (normal weight, overweight, obese) and the presence of metabolic syndrome (MetS) according to the NCEP consensus criteria. Results: The severity of coronary artery stenosis was increased in individuals with obesity without MetS compared to normal-weight individuals without MetS (OR 1.47, 95%CI 1.34–1.62; p < 0.0001), even after adjusting for non-HDL-cholesterol and several lifestyle factors. Such difference was not observed for the presence of carotid artery plaques (OR 0.94, 95%CI 0.87–1.02; p = 0.11). Obese or overweight individuals without any MetS criteria (except the waist criterion) showed significantly more pronounced stenosis in the coronary arteries as compared to the normal-weight individuals, while one criterion was needed to show increased plaque prevalence in the carotid arteries. High blood pressure was the most important single criterion for increased atherosclerosis in this respect. Conclusions: Individuals with obesity without MetS showed increased severity of coronary artery stenosis, but no increased occurrence of carotid artery plaques compared to normal-weight individuals without MetS, further emphasizing that obesity is not a benign condition even in the absence of MetS.
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| 2. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 3. |
- Shungin, Dmitry, et al.
(författare)
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New genetic loci link adipose and insulin biology to body fat distribution.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
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Tidskriftsartikel (refereegranskat)abstract
- Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
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| 5. |
- Eriksson, Owen, et al.
(författare)
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The Functionality of Conceptual Standards in the E-service Production Process
- 2006
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Ingår i: Action in Language, Organisations and Information Systems (ALOIS 2006) - Fourth International Conference. - Borås.
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Konferensbidrag (refereegranskat)abstract
- The paper presents a case study conducted at the Swedish Road Administration (the SRA) focussing on the RDS-TMC service, a type of e-service. The implementation of the RDS-TMC service is based on two conceptual standards: the ALERT-C and Location Code standards. The main purpose of the case study has been to understand the functionality (role) of these standards by investigating how the SRA has implemented and used the standards behind the RDS-TMC service in order to provide the service.
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| 8. |
- Karlsson, Patrik, 1973-, et al.
(författare)
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Galling resistance evaluation of tool steels by two different laboratory test methods for sheet metal forming
- 2012
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Ingår i: Lubrication Science. - : John Wiley & Sons. - 0954-0075 .- 1557-6833. ; 24:6, s. 263-272
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Tidskriftsartikel (refereegranskat)abstract
- Adhesive accumulation of work material on the tool surface is today a major problem in many sheet metal-forming applications. Different laboratory test methods are used to investigate galling with respect to different tool materials, lubricants and process conditions. In the present study, the galling resistance of a modern nitrogen-alloyed powder metallurgy tool steel and an conventional ingot cast D2 type tool steel was evaluated under lubricated sliding against ferritic stainless steel sheets using a commercial pin-on-disc (POD) and an in-house made slider-on-flat-surface (SOFS) tribotester. The investigated tool steels ranked similarly in terms of galling resistanc in both test methods. However, sliding distances to galling were longer for the SOFS equipment due to continuous sliding on new lubricated sheet surface. Best performance was demonstrated by the powder metallurgy tool steel treated to 65 HRC. Differences in friction behaviour and galling initiation were analysed on the basis of the two different working conditions, i.e. open (SOFS) and closed (POD) tribosystems. Copyright © 2012 John Wiley & Sons, Ltd.
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