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Numrering	Referens	Omslagsbild	Hitta
1.	Eriksson, Olof, et al. (författare) Quantitative Imaging of Serotonergic Biosynthesis and Degradation in the Endocrine Pancreas 2014 Ingår i: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 55:3, s. 460-465 Tidskriftsartikel (refereegranskat)abstract Serotonergic biosynthesis in the endocrine pancreas, of which the islets of Langerhans is the major constituent, has been implicated in insulin release and β cell proliferation. In this study, we investigated the feasibility of quantitative noninvasive imaging of the serotonergic metabolism in the pancreas using the PET tracer (11)C-5-hydroxy-l-tryptophan ((11)C-5-HTP).METHODS: Uptake of (11)C-5-HTP, and its specificity for key enzymes in the serotonergic metabolic pathway, was assessed in vitro (INS-1 and PANC1 cells and human islet and exocrine preparations) and in vivo (nonhuman primates and healthy and diabetic rats).RESULTS: In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellular conversion into serotonin. Pancreatic uptake of (11)C-5-HTP in nonhuman primates was markedly decreased by inhibition of the enzyme dopa decarboxylase, which converts (11)C-5-HTP to (11)C-serotonin and increased after inhibition of monoamine oxidase-A, the main enzyme responsible for serotonin degradation. Uptake in the rat pancreas was similarly modulated by inhibition of monoamine oxidase-A and was reduced in animals with induced diabetes.CONCLUSION: The PET tracer (11)C-5-HTP can be used for quantitative imaging of the serotonergic system in the endocrine pancreas.
2.	Eriksson, Olof, et al. (författare) The Positron Emission Tomography ligand [11C]5-Hydroxy-Tryptophan can be used as a surrogate marker for the human endocrine pancreas 2014 Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 63:10, s. 3428-3437 Tidskriftsartikel (refereegranskat)abstract In humans a well-developed serotonin system is localized to the pancreatic islets while being absent in exocrine pancreas. Assessment of pancreatic serotonin biosynthesis could therefore be used to estimate the human endocrine pancreas. Proof of concept was tested in a prospective clinical trial by comparisons of type 1 diabetic (T1D) patients, with extensive reduction of beta cells, with healthy volunteers (HV).C-peptide negative (i.e. insulin-deficient) T1D subjects (n=10) and HV (n=9) underwent dynamic Positron Emission Tomography with the radiolabeled serotonin precursor [(11)C]5-Hydroxy-Tryptophan ([(11)C]5-HTP).A significant accumulation of [(11)C]5-HTP was obtained in the pancreas of the HV, with large inter-individual variation. A substantial and highly significant reduction (66%) in the pancreatic uptake of [(11)C]5-HTP in T1D subjects was observed, and this was most evident in the corpus and caudal regions of the pancreas where beta-cells normally are the major constituent of the islets.[(11)C]5-HTP retention in the pancreas was reduced in T1D compared to non-diabetic subjects. Accumulation of [(11)C]5-HTP in the pancreas of both HV and subjects with T1D were in agreement with previously reported morphological observations on the beta cell volume implying that [(11)C]5-HTP retention is a useful non-invasive surrogate marker for the human endocrine pancreas.
3.	Aad, G., et al. (författare) A search for high-mass resonances decaying to tau(+)tau(-) in pp collisions at root s=8 TeV with the ATLAS detector 2015 Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :7 Tidskriftsartikel (refereegranskat)
4.	Aad, G, et al. (författare) Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector. 2014 Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:14 Tidskriftsartikel (refereegranskat)
5.	Aad, G, et al. (författare) Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at sqrt[s]=8 TeV Using the ATLAS Detector. 2015 Ingår i: Physical Review Letters. - : Elsevier. - 1079-7114 .- 0031-9007. ; 114:14 Tidskriftsartikel (refereegranskat)
6.	Aad, G, et al. (författare) Measurement of the top-quark mass in the fully hadronic decay channel from ATLAS data at [Formula: see text]. 2015 Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:4 Tidskriftsartikel (refereegranskat)
7.	Aad, G, et al. (författare) Measurements of Four-Lepton Production at the Z Resonance in pp Collisions at sqrt[s]=7 and 8 TeV with ATLAS. 2014 Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:23 Tidskriftsartikel (refereegranskat)
8.	Aad, G, et al. (författare) Measurements of the [Formula: see text] production cross sections in association with jets with the ATLAS detector. 2015 Ingår i: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:2 Tidskriftsartikel (refereegranskat)
9.	Aad, G, et al. (författare) Measurements of the Nuclear Modification Factor for Jets in Pb+Pb Collisions at sqrt[s_{NN}]=2.76 TeV with the ATLAS Detector. 2015 Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 114:7 Tidskriftsartikel (refereegranskat)
10.	Aad, G, et al. (författare) Observation of an Excited B_{c}^{±} Meson State with the ATLAS Detector. 2014 Ingår i: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 113:21 Tidskriftsartikel (refereegranskat)

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