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- Hieronymus, Fredrik, et al.
(författare)
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The alleged ineffectiveness of SSRIs in depression is an artefact caused by the use of an inappropriate measure of efficacy
- 2014
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Ingår i: International Journal of Neuropsychopharmacology vol. 17 Supplement 1. 29th CINP World Congress of Neuropsychopharmacology, Vancouver, Canada, 22–26 June 2014. - New York : Cambridge University Press. - 1461-1457 .- 1469-5111.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Objective: Many studies have questioned if summation of the scores of the 17 disparate items constituting the Hamilton Depression Rating Scale (HDRS-17) is a reliable index of severity in depression; yet the cur- rent questioning of the ef fi cacy of antidepressant drugs is to a large extent based on the assumption that response to treatment is reliably re fl ected by this instrument. We aimed to investigate the possibility that the shortcom- ings of the HDRS may contribute to the failure of antidepressants to out- perform placebo in many trials. Methods: We analyzed thirteen industry-sponsored trials of selective serotonin reuptake inhibitors (SSRIs) comprising twenty-four drug- placebo comparisons and including patient-level data from 5381 subjects (administered paroxetine, citalopram, fl uoxetine, or placebo), the aim being to assess what the outcome would have been if the single item de- pressed mood (rated 0 – 4) had been used as measure of ef fi cacy. Results: While 12 out of 24 comparisons (50%) revealed a signi fi cant difference between active drug and placebo at week 6 with respect to re- duction in HDRS-17-sum, 23 out of 24 comparisons (96%) showed the ac- tive drug to be superior to placebo in reducing depressed mood. Correspondingly, a pooled analysis of all cases showed the effect size when assessed using the HDRS-17-sum to be 0.30, whereas it, when mea- sured using the depressed mood item alone, was 0.42. Conclusion: While not claiming that measuring one item only is the most appropriate way of recording symptom severity in depression, we do suggest that the inclusion of a number of varying symptoms in the as- sessment, some of which may be side-effects of treatment and/or are unre- lated to the disorder, reduces the sensitivity to detect a difference between active drug and placebo. This lack of sensitivity of HDRS-17 might partly explain why a high fraction of antidepressant trials fail to reveal a signi fi - cant difference between treatment groups
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| 3. |
- Aghajanian, G. K., et al.
(författare)
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Torgny Svensson, M.D., Ph.D. (1945-2020)
- 2020
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Ingår i: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. - : Springer Science and Business Media LLC. - 1740-634X. ; 45:11
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Eriksson, Elias, 1956
(författare)
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Om hjärnans kemi vid ADHD
- 2004
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Ingår i: ADHD/DAMP - en uppdatering. - : Studentlitteratur. ; , s. 47-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Eriksson, Elias, 1956
(författare)
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Premenstrual syndrome: A case of serotonin
- 2008
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Ingår i: The Premenstrual syndromes. - London : Informa Health Care. ; , s. 21-26
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Suchankova, Petra, 1979, et al.
(författare)
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Associations between personality traits and polymorphisms in genes related to inflammation in women
- 2008
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Ingår i: XVIth World Congress on Psychiatric Genetics.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Both inflammation and certain personality traits have been associated with depression; however, studies regarding the relationship between inflammation and general brain functions are not numerous. The present study investigates two single nucleotide polymorphisms located in genes that are associated with inflammation with regards to personality traits in 270 women recruited from the population registry. These women were assessed by means of Karolinska Scale of Personality, a self-reported inventory. The first polymorphism, +1444C>T (rs1130864), is located in the gene coding for C-reactive protein (CRP), a marker of low-grade inflammation, and has previously been linked to raised serum levels of high-sensitivity CRP. The second polymorphism, Y402H (rs1061170), is located in the gene coding for complement factor H (CFH), an important regulator of the complement system. CRP binds to CFH and thereby augments the ability of CFH to down regulate the alternative pathway of complement. The 402H allele has consistently been associated with age-related macular degeneration and was recently linked to Alzheimer’s disease. The +1444T allele was significantly associated with higher scores in the personality traits impulsiveness, monotony avoidance and social desirability (p<0.001, p=0.004 and p=0.012, respectively). The 402H polymorphism was significantly associated with higher levels of the personality trait verbal aggression (p=0.002). In conclusion, the association between the studied CRP and CFH polymorphisms and personality traits further supports the possible involvement of the immune system in mental functions.
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