| 1. |
- Eriksson, Eva, 1976, et al.
(författare)
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Digital Fabrication by IDAC – Aims, Steps and Transferable Principles
- 2014
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Ingår i: FabLearn Europe 2014.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper aims to present the digital fabrication approach driven by Gothenburg Working group for Interaction Design and Children – IDAC in Sweden. In addition to supporting local makerspace environments, educating teachers, school leaders and politicians, and conducting hacker clubs for children, we suggest including children in special education in a European agenda for digital fabrication at school, and make the maker movement matter for all children. In this paper, we identify three transferable principles for this.
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| 2. |
- Eriksson, Jonathan, et al.
(författare)
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Preoperative MRI in women with newly diagnosed breast cancer: re-excision rates and additional findings
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- AbstractBackground: Preoperative breast magnetic resonance imaging (MRI) is still controversial as an adjunct to conventional breast cancer workup in terms of the effect on re-excision rates. Our objective was to analyse whether the introduction of preoperative breast MRI influences the rate of re-excisions in women with newly diagnosed breast cancer and to study the additional ipsi- and contralateral MRI findings and their impact on surgical management.Methods: Women with newly diagnosed breast cancer having preoperative MRI and surgery at Vastmanland County Hospital Breast Unit from January–June 2018 (n = 84) were compared with women not undergoing preoperative MRI from January–June 2016 (n = 97). Data were collected from retrospective reviews of patients’ medical records.Results: The re-excision rate was one of 84 (1.2%) in 2018 and three of 97 (3.1%) in 2016. There was no statistically significant difference in re-excision rates between the two study periods. In the MRI cohort, seven patients of 84 (8%) had malignancy in the ipsilateral and two (2%) in the contralateral breast not previously detected by conventional imaging. Additional malignant findings were more common in women of age < 59 years, and more often resulted in mastectomy.Conclusions: Preoperative breast MRI in women with newly diagnosed breast cancer did not reduce the number of re-excisions. Additional malignant findings were more common in women younger than 59 years and influenced surgical management. MRI resulted in no delay of surgery.
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| 3. |
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| 4. |
- Granberg, Dan, et al.
(författare)
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Liver embolization with trisacryl gelatin microspheres (embosphere) in patients with neuroendocrine tumors
- 2007
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 48:2, s. 180-185
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To report our experience of liver embolization with trisacryl gelatin microspheres (Embospheretrade mark) in patients with metastatic neuroendocrine tumors. MATERIAL AND METHODS: Fifteen patients underwent selective embolization of the right or left hepatic artery with Embosphere. One lobe was embolized in seven patients and both lobes, on separate occasions, in eight patients. Seven patients had midgut carcinoids, two had lung carcinoids, one suffered from a thymic carcinoid, and five had endocrine pancreatic tumors. Eight patients suffered from endocrine symptoms, seven of whom had carcinoid syndrome and one WDHA (watery diarrhea, hypokalemia, achlorhydria) syndrome. RESULTS: Partial radiological response was seen after eight embolizations (in six different patients), stable disease was observed after 13 embolizations (after three of these, necroses occurred), while radiological progression was noted after only two embolizations. Only two patients experienced a biochemical response. Clinical improvement of carcinoid syndrome was observed after five embolizations. There were no major complications. Fever >38 degrees C was seen after all but four embolizations, and urinary tract infections were diagnosed after eight embolizations. CONCLUSION: Selective hepatic artery embolization with Embosphere particles is a safe treatment for patients with metastatic neuroendocrine tumors and may lead to partial radiological response as well as symptomatic improvement of disabling endocrine symptoms.
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| 5. |
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| 6. |
- Venge, Per, et al.
(författare)
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HNL (Human Neutrophil Lipocalin) and a multimarker approach to the distinction between bacterial and viral infections
- 2019
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Ingår i: JIM - Journal of Immunological Methods. - : Elsevier. - 0022-1759 .- 1872-7905. ; 474
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The distinction between bacterial and viral causes of acute infections is a major clinical challenge. In this report we investigate the diagnostic performance in this regard of nine candidate biomarkers together with HNL (Human Neutrophil Lipocalin).METHODS: Blood was obtained from patients with symptoms of infectious (n = 581). HNL was measured in whole blood (B-HNL) after pre-activation with the neutrophil activator fMLP or in plasma (P-HNL). Azurocidin also known as heparin-binding protein (HBP), Calprotectin, PMN-CD64, CRP (C-reactive protein), IP-10 (Interferon γ-induced Protein 10 kDa), PCT (Procalcitonin), TK1 (Thymidine kinase 1), TRAIL (TNF-related apoptosis-inducing ligand) were measured in plasma/serum. Area under the ROC (receiver operating characteristics) curve (AuROC) was used for the evaluation of the clinical performance of the biomarkers.RESULTS: Side-by-side comparisons of the ten biomarkers showed large difference in the AuROC with B-HNL being the superior biomarker (0.91, 95% CI 0.86-0.95) and with the other nine biomarkers varying from AuROC of 0.63-0.79. The combination of B-HNL with IP-10 and/or TRAIL increased the diagnostic performance further to AuROCs of 0.94-0.97. The AuROCs of the combination of CRP with IP-10 and/or TRAIL were significantly lower than combinations with B-HNL 0.87 (95% CI 0.83-0.91).CONCLUSION: The diagnostic performance of whole blood activated HNL was superior in the distinction between bacterial or viral infections. The addition of IP-10 and/or TRAIL to the diagnostic algorithm increased the performance of B-HNL further. The rapid analysis of HNL, reflecting bacterial infections, together with biomarkers reflecting viral infections may be the ideal combination of diagnostic biomarkers of acute infections.
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| 7. |
- Wiberg, Erik, et al.
(författare)
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A validation study of cT-categories in the Swedish national urinary bladder cancer register - Norrland University Hospital
- 2023
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Ingår i: Journal of Personalized Medicine. - : MDPI. - 2075-4426. ; 13:7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: In Sweden, all patients with urinary bladder cancer (UBC) are recorded in the Swedish National Register for Urinary Bladder Cancer (SNRUBC). The purpose of this study was to validate the registered clinical tumour categories (cT-categories) in the SNRUBC for Norrland University Hospital, Sweden, from 2009 to 2020, inclusive.METHODS: The medical records of all 295 patients who underwent radical cystectomy for the treatment of UBC were reviewed retrospectively. Possible factors impacting the cT-categories were identified. To optimise cT-classification, computed tomography urography of all patients with suspected tumour-associated hydronephrosis (TAH) or suspected tumour in bladder diverticulum (TIBD) were retrospectively reviewed by a radiologist. Discrepancy was tested with a logistic regression model.RESULTS: cT-categories differed in 87 cases (29.5%). Adjusted logistic regression analysis found TIBD and TAH as significant predictors for incorrect registration; OR = 7.71 (p < 0.001), and OR = 17.7, (p < 0.001), respectively. In total, 48 patients (68.6%) with TAH and 12 patients (52.2%) with TIBD showed discrepancy regarding the cT-category. Incorrect registration was mostly observed during the years 2009-2012.CONCLUSION: The study revealed substantial incorrect registration of cT-categories in SNRUBC. A major part of the misclassifications was related to TAH and TIBD. Registration of these variables in the SNRUBC might be considered to improve correct cT-classification.
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| 8. |
- Alexandersson, Maria, et al.
(författare)
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A small difference in recovery between total knee arthroplasty with and without tourniquet use the first 3 months after surgery : a randomized controlled study
- 2019
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Ingår i: Knee Surgery, Sports Traumatology, Arthroscopy. - : Springer. - 0942-2056 .- 1433-7347. ; 27:4, s. 1035-1042
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: When a tourniquet is used during surgery on the extremities, the pressure applied to the muscles, nerves and blood vessels can cause neuromuscular damage that contributes to postoperative weakness. The hypothesis was that the rehabilitation-related results would be improved if total knee arthroplasty (TKA) is performed without the use of a tourniquet.Methods: 81 patients with osteoarthritis of the knee who underwent TKA surgery were randomized to surgery with or without tourniquet. Active flexion and extension of the knee, pain by visual analog scale (VAS), swelling by knee circumference, quadriceps function by straight leg raise, and timed up and go (TUG) test results were measured before and up to 3 months after surgery.Results: ANCOVA revealed no between-groups effect for flexion of the knee at day 3 postsurgery. Compared with the tourniquet group, the nontourniquet group experienced elevated pain at 24 h, with a mean difference of 16.6 mm, p = 0.005. The effect on mobility (TUG test) at 3 months was better in the nontourniquet group, with a mean difference of -1.1 s, p = 0.029.Conclusions: The hypothesis that the rehabilitation-related results would be improved without a tourniquet is not supported by the results. When the results in this study for surgery performed with and without tourniquet are compared, no clear benefit for either procedure was observed, as the more pain exhibited by the nontourniquet group was only evident for a short period and the improved mobility in this group was not at a clinically relevant level.Level of evidence: Inconsistent results, Level II.
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| 9. |
- Andersson, Staffan, 1969-, et al.
(författare)
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Democracy and technocracy in Sweden's Experience of the COVID-19 Pandemic
- 2022
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Ingår i: Frontiers in Political Science. - : Frontiers Media S.A.. - 2673-3145. ; 4, s. 1-13
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Tidskriftsartikel (refereegranskat)abstract
- Sweden’s management of the coronavirus pandemic, beginning in early 2020, hasbeen much discussed because it deviated from other countries’ equivalents. Set inthe context of scholarly debate about the balance between politicians and experts inpolitical decision-making, we argue that a necessary condition for this case of Swedishexceptionalism was the manner of policy-making adopted by the Swedish authorities. Inthis article, we describe this policy-making procedure, which involved a radical form ofdelegation by elected politicians to appointed experts, and seek to explain how it cameabout. We focus on the 1st year of the pandemic, and use media reports and other publicdocuments, including parts of a public inquiry, as our empirical material.
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