| 1. |
- Michel, M., et al.
(författare)
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
- 2022
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Ingår i: Science. - Stockholm : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1471-1476
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Tidskriftsartikel (refereegranskat)abstract
- Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging. © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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| 2. |
- Przyklenk, A., et al.
(författare)
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AdvManuNet : Support for a European Metrology Network for advanced manufacturing
- 2021
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Ingår i: Proceedings of the 21st International Conference of the European Society for Precision Engineering and Nanotechnology, EUSPEN 2021. - : euspen. - 9780995775190 ; , s. 321-322
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Konferensbidrag (refereegranskat)abstract
- Advanced manufacturing has been identified as one of the key enabling technologies (KET) with applications in multiple industries. Advanced manufacturing requires new and enhanced metrology methods to assure the quality of manufacturing processes and resulting products. However, a high-level coordination of the metrology community in Europe is currently absent in this domain and limits the impact of metrology developments on advanced manufacturing. This gap aims to be closed through the establishment of a European Metrology Network (EMN) for advanced manufacturing. Here we report on the approach, first activities and the latest progress to establish a EMN on advanced manufacturing within EURAMET, the European Association of National Metrology Institutes (NMI). The objectives of this EMN are to set up a permanent stakeholder dialogue, to develop a Strategic Research Agenda (SRA) for metrology input needed for advanced manufacturing technologies, to create and maintain a knowledge sharing programme and to implement a web-based service desk for stakeholders involved in advanced manufacturing.
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| 3. |
- Bosse, H., et al.
(författare)
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AdvManuNet : A networking project on metrology for advanced manufacturing
- 2020
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Ingår i: Proceedings of the 20th International Conference of the European Society for Precision Engineering and Nanotechnology, EUSPEN 2020. - : euspen. - 9780995775176 ; , s. 357-358
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Konferensbidrag (refereegranskat)abstract
- The networking project AdvManuNet has been started recently to accelerate the process of establishing an European Metrology Network (EMN) on Advanced Manufacturing. EMNs are intended by EURAMET, the association of metrology institutes in Europe, to provide a sustainable structure for ongoing stakeholder interaction in different thematic areas. Advanced manufacturing has been identified by the European Commission (EC) as one of six Key Enabling Technologies (KETs) with applications in multiple industries. Various EURAMET projects have partly addressed metrology needs for advanced manufacturing. However, a high-level coordination of the metrology community is currently absent and limits the impact of metrology developments on advanced manufacturing. AdvManuNet will address these limits by establishing a single hub for stakeholder consultation, a knowledge base on research results, and a strategic agenda for research and training to push forward advanced manufacturing and related KETs and strengthen Europe's position in advanced manufacturing via the EMN.
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