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Renal dysfunction i...
Renal dysfunction in patients with heart failure with preserved versus reduced ejection fraction: impact of the new Chronic Kidney Disease-Epidemiology Collaboration Group formula.
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McAlister, Finlay A (author)
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Ezekowitz, Justin (author)
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Tarantini, Luigi (author)
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Squire, Iain (author)
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Komajda, Michel (author)
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Bayes-Genis, Antoni (author)
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Gotsman, Israel (author)
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Whalley, Gillian (author)
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Earle, Nikki (author)
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Poppe, Katrina K (author)
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Doughty, Robert N (author)
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- Andersson, Bert, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Circulation. Heart failure. - 1941-3297. ; 5:3, s. 309-14
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Prior studies in heart failure (HF) have used the Modification of Diet in Renal Disease (MDRD) equation to calculate estimated glomerular filtration rate (eGFR). The Chronic Kidney Disease-Epidemiology Collaboration Group (CKD-EPI) equation provides a more-accurate eGFR than the MDRD when compared against the radionuclide gold standard. The prevalence and prognostic import of renal dysfunction in HF if the CKD-EPI equation is used rather than the MDRD is uncertain.We used individual patient data from 25 prospective studies to stratify patients with HF by eGFR using the CKD-EPI and the MDRD equations and examined survival across eGFR strata. In 20 754 patients (15 962 with HF with reduced ejection fraction [HF-REF] and 4792 with HF with preserved ejection fraction [HF-PEF]; mean age, 68 years; deaths per 1000 patient-years, 151; 95% CI, 146-155), 10 589 (51%) and 11 422 (55%) had an eGFR <60 mL/min using the MDRD and CKD-EPI equations, respectively. Use of the CKD-EPI equation resulted in 3760 (18%) patients being reclassified into different eGFR risk strata; 3089 (82%) were placed in a lower eGFR category and exhibited higher all-cause mortality rates (net reclassification improvement with CKD-EPI, 3.7%; 95% CI, 1.5%-5.9%). Reduced eGFR was a stronger predictor of all-cause mortality in HF-REF than in HF-PEF.Use of the CKD-EPI rather than the MDRD equation to calculate eGFR leads to higher estimates of renal dysfunction in HF and a more-accurate categorization of mortality risk. Renal function is more closely related to outcomes in HF-REF than in HF-PEF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Adult
- Age Factors
- Aged
- Aged
- 80 and over
- Chronic Disease
- Female
- Glomerular Filtration Rate
- physiology
- Heart Failure
- complications
- mortality
- physiopathology
- Humans
- Kidney
- physiopathology
- Kidney Diseases
- epidemiology
- physiopathology
- Male
- Middle Aged
- Models
- Biological
- Prevalence
- Prognosis
- Prospective Studies
- Risk Factors
- Stroke Volume
- physiology
- Survival Rate
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McAlister, Finla ...
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Ezekowitz, Justi ...
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Tarantini, Luigi
-
Squire, Iain
-
Komajda, Michel
-
Bayes-Genis, Ant ...
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show more...
-
Gotsman, Israel
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Whalley, Gillian
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Earle, Nikki
-
Poppe, Katrina K
-
Doughty, Robert ...
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Andersson, Bert, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation. Hea ...
- By the university
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University of Gothenburg