| 1. |
- Santoro, Aurelia, et al.
(författare)
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Combating inflammaging through a Mediterranean whole diet approach : The NU-AGE project's conceptual framework and design
- 2014
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Ingår i: Mechanisms of Ageing and Development. - Clare, Ireland : Elsevier BV. - 0047-6374 .- 1872-6216. ; 136-137, s. 3-13
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Tidskriftsartikel (refereegranskat)abstract
- The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.
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| 2. |
- Lagathu, C., et al.
(författare)
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Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.
- 2010
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Ingår i: International Journal of Obesity. - London, United Kingdom : Nature Publishing Group. - 0307-0565 .- 1476-5497. ; 34:12, s. 1695-1705
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Tidskriftsartikel (refereegranskat)abstract
- AIM: The Wnt/β-catenin signaling network offers potential targets to diagnose and uncouple obesity from its metabolic complications. In this study, we investigate the role of the Wnt antagonist, secreted frizzled-related protein 1 (SFRP1), in promoting adipogenesis in vitro and adipose tissue expansion in vivo.METHODS: We use a combination of human and murine, in vivo and in vitro models of adipogenesis, adipose tissue expansion and obesity-related metabolic syndrome to profile the involvement of SFRP1.RESULTS: SFRP1 is expressed in both murine and human mature adipocytes. The expression of SFRP1 is induced during in vitro adipogenesis, and SFRP1 is preferentially expressed in mature adipocytes in human adipose tissue. Constitutive ectopic expression of SFRP1 is proadipogenic and inhibits the Wnt/β-catenin signaling pathway. In vivo endogenous levels of adipose SFRP1 are regulated in line with proadipogenic states. However, in longitudinal studies of high-fat-diet-fed mice, we observed a dynamic temporal but biphasic regulation of endogenous SFRP1. In agreement with this profile, we observed that SFRP1 expression in human tissues peaks in patients with mild obesity and gradually falls in morbidly obese subjects.CONCLUSIONS: Our results suggest that SFRP1 is an endogenous modulator of Wnt/β-catenin signaling and participates in the paracrine regulation of human adipogenesis. The reduced adipose expression of SFRP1 in morbid obesity and its knock-on effect to prevent further adipose tissue expansion may contribute to the development of metabolic complications in these individuals.
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| 3. |
- Burisch, J., et al.
(författare)
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Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease : An ECCO-EpiCom study
- 2014
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Ingår i: Journal of Crohn's & Colitis. - Oxford, United Kingdom : Oxford University Press. - 1873-9946 .- 1876-4479. ; 8:9, s. 1030-1042
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.
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| 4. |
- Mariscal-Arcas, M., et al.
(författare)
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Nutritional analysis of diet at base camp of a seven thousand-metre mountain in the Himalayas
- 2010
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Ingår i: Revista Andaluza de Medicina del Deporte. - : Elsevier. - 1888-7546. ; 3:4, s. 127-132
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To evaluate the diet of a group of high-mountain climbers at 4,500 metres.Methods: A descriptive cross-sectional study was performed on the diet of a group of high-mountain climbers at their base camp (4,500 m).Results: The mean intake was 11.85 MJ/day (2,833 kcal/day), which provided an inadequate supply of energy and micronutrients to replenish deposits. Their mean carbohydrate intake (39.5%) was excessively low, since carbohydrate-rich diet favours acclimatization and the capacity for recovery. Their daily intake of 1.5-2.5 g/protein/kg of bodyweight was very similar to recommendations (1.5-2.0 g/kg/day).Conclusions: The climbers underwent a drastic change from their habitual Mediterranean diet, rich in monounsaturated fats (largely olive oil), to a diet rich in polyunsaturated fats (largely soy oil). The Sherpa-prepared diet on this expedition was not balanced. It was rich in saturated polyunsaturated fats and relatively poor in proteins and especially carbohydrates, similar to the traditional diet of climbers. Dietary strategies need to be developed to increase the intake of nutrients that favours the physical recovery of climbers and their altitude-acclimatization and to avoid micronutrient deficiencies.
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| 5. |
- Palacin-Arce, A., et al.
(författare)
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Analysis of the drinks that contribute to the hydration of andalusian sportspeople
- 2013
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Ingår i: Revista Andaluza de Medicina del Deporte. - : Elsevier. - 1888-7546. ; 6:1, s. 12-16
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Tidskriftsartikel (refereegranskat)abstract
- Objectives. To estimate the water balance in a healthy population of sportspeople from Southern Spain and determine the sources of their fluid intake, evaluating the contribution of different types of drink and comparing the results by sex and province of residence.Methods. Three hundred eighty-six sportspeople (231 males, 152 females) were enrolled in the study. A questionnaire was administered to calculate nutrient intake through diet and physical activity, and anthropometric measures were taken according to ISAK standards. SPSS-15 was used for data analyses.Results. Fruit juice, tap water, bottled water, processed fruit juice, carbonated drinks, and isotonic drinks comprised 96% of the total water intake. Simple sugar consumption represented 4.44% of daily calorie intake. Significant differences were found between sexes and between professionals and amateurs. The amount of drinks consumed varied as a function of the quality of the drinking water, which significantly differed among the eight Andalusian provinces.Conclusion. This study population did not fully meet fluid intake recommendations, compliance with hydration recommendations varied as a function of the sex and the amateur or professional status of these sportspeople. The pattern of drinks consumption also differed according to their place of residence.
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| 6. |
- Mariscal-Arcas, M., et al.
(författare)
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Follow-up study of diet and nutritional and physical state of young expert Alpine skiers at a training camp : [Estudio del seguimiento nutricional y estado físico de jóvenes esquiadores expertos durante una concentración de entrenamiento]
- 2011
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Ingår i: Revista Andaluza de Medicina del Deporte. - : Elsevier. - 1888-7546 .- 2172-5063. ; 4:3, s. 114-120
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the diet, body composition and physical condition of six young Spanish skiers away from parental control and able to choose their own meals during a training stay at a Chilean ski resort.Methods: A protocol was developed to record diet, physical condition, training activity, and other incidences. Anthropometric measurements were taken weekly following the Spanish Sports Council protocol for the detection of sport talents. Their physical condition was examined every two weeks.Results: The six young Alpine skiers showed a considerably higher protein intake than recommendations and a mean percentage of energy from carbohydrates very close to the recommended percentage. The best predictor of iron status is considered to be the proportion of total protein in the diet. This proportion was considerably below recommendations. The BMI and %fat were negatively correlated with performance in flexibility, sit-ups and balance tests.Conclusions: The body composition of these young sportspeople influenced some physical test results. Despite the absence of parental influence, these children at this training camp freely selected a diet appropriate to their needs.
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