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| 2. |
- de Rojas, I., et al.
(författare)
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- 2021
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Tidskriftsartikel (refereegranskat)abstract
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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| 3. |
- Bellenguez, C, et al.
(författare)
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New insights into the genetic etiology of Alzheimer's disease and related dementias
- 2022
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 54:4, s. 412-436
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Tidskriftsartikel (refereegranskat)abstract
- Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
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| 4. |
- Aprile, E., et al.
(författare)
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Search for New Physics in Electronic Recoil Data from XENONnT
- 2022
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 129:16
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Tidskriftsartikel (refereegranskat)abstract
- We report on a blinded analysis of low-energy electronic recoil data from the first science run of the XENONnT dark matter experiment. Novel subsystems and the increased 5.9 ton liquid xenon target reduced the background in the (1, 30) keV search region to (15.8±1.3) events/(ton×year×keV), the lowest ever achieved in a dark matter detector and ∼5 times lower than in XENON1T. With an exposure of 1.16 ton-years, we observe no excess above background and set stringent new limits on solar axions, an enhanced neutrino magnetic moment, and bosonic dark matter.
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| 5. |
- Althueser, L., et al.
(författare)
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GPU-based optical simulation of the DARWIN detector
- 2022
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 17:7
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Tidskriftsartikel (refereegranskat)abstract
- Understanding propagation of scintillation light is critical for maximizing the discovery potential of next-generation liquid xenon detectors that use dual-phase time projection chamber technology. This work describes a detailed optical simulation of the DARWIN detector implemented using Chroma, a GPU-based photon tracking framework. To evaluate the framework and to explore ways of maximizing efficiency and minimizing the time of light collection, we simulate several variations of the conventional detector design. Results of these selected studies are presented. More generally, we conclude that the approach used in this work allows one to investigate alternative designs faster and in more detail than using conventional Geant4 optical simulations, making it an attractive tool to guide the development of the ultimate liquid xenon observatory.
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| 6. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
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Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s=13 TeV
- 2022
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Ingår i: Journal of High Energy Physics (JHEP). - : Springer Nature. - 1126-6708 .- 1029-8479. ; :6
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Tidskriftsartikel (refereegranskat)abstract
- Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at √s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and O(8)tq, where the limits on the latter are the most stringent to date.
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| 7. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
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Search for heavy particles in the b-tagged dijet mass distribution with additional b-tagged jets in proton-proton collisions at √s=13 TeV with the ATLAS experiment
- 2022
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Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 105:1
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Tidskriftsartikel (refereegranskat)abstract
- A search optimized for new heavy particles decaying to two b-quarks and produced in association with additional b-quarks is reported. The sensitivity is improved by b-tagging at least one lower-pT jet in addition to the two highest-pT jets. The data used in this search correspond to an integrated luminosity of 103 fb−1 collected with a dedicated trijet trigger during the 2017 and 2018 √s=13 TeV proton-proton collision runs with the ATLAS detector at the LHC. The search looks for resonant peaks in the b-tagged dijet invariant mass spectrum over a smoothly falling background. The background is estimated with an innovative data-driven method based on orthonormal functions. The observed b-tagged dijet invariant mass spectrum is compatible with the background-only hypothesis. Upper limits at 95% confidence level on a heavy vector-boson production cross section times branching ratio to a pair of b-quarks are derived.
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| 8. |
- Andrean, Stefio Y., 1991-, et al.
(författare)
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Search for single production of a vectorlike T quark decaying into a Higgs boson and top quark with fully hadronic final states using the ATLAS detector
- 2022
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Ingår i: Physical Review D. - : American Physical Society (APS). - 2470-0010 .- 2470-0029. ; 105:9
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Tidskriftsartikel (refereegranskat)abstract
- A search is made for a vectorlike T quark decaying into a Higgs boson and a top quark in 13 TeV proton-proton collisions using the ATLAS detector at the Large Hadron Collider with a data sample corresponding to an integrated luminosity of 139 fb−1. The Higgs-boson and top-quark candidates are identified in the all-hadronic decay mode, where H → bb¯ and t → bW → bqq¯′ are reconstructed as large-radius jets. The candidate Higgs boson, top quark, and associated B hadrons are identified using tagging algorithms. No significant excess is observed above the background, so limits are set on the production cross section of a singlet T quark at 95% confidence level, depending on the mass mT and coupling κT of the vectorlike T quark to Standard Model particles. In the considered mass range between 1.0 and 2.3 TeV, the upper limiton the allowed coupling values increases with mT from a minimum value of 0.35 for 1.07 < mT < 1.4 TeV to 1.6 for mT=2.3 TeV.
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| 9. |
- G., Aad, et al.
(författare)
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CP Properties of Higgs Boson Interactions with Top Quarks in the t t ¯ H and tH Processes Using H →γγ with the ATLAS Detector
- 2020
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Ingår i: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 125:6
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Tidskriftsartikel (refereegranskat)abstract
- A study of the charge conjugation and parity (CP) properties of the interaction between the Higgs boson and top quarks is presented. Higgs bosons are identified via the diphoton decay channel (H→γγ), and their production in association with a top quark pair (tt¯H) or single top quark (tH) is studied. The analysis uses 139 fb-1 of proton-proton collision data recorded at a center-of-mass energy of s=13 TeV with the ATLAS detector at the Large Hadron Collider. Assuming a CP-even coupling, the tt¯H process is observed with a significance of 5.2 standard deviations. The measured cross section times H→γγ branching ratio is 1.64-0.36+0.38(stat)-0.14+0.17(sys) fb, and the measured rate for tt¯H is 1.43-0.31+0.33(stat)-0.15+0.21(sys) times the Standard Model expectation. The tH production process is not observed and an upper limit on its rate of 12 times the Standard Model expectation is set. A CP-mixing angle greater (less) than 43 (-43)° is excluded at 95% confidence level. © 2020 CERN.
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| 10. |
- Mullier, G.A., et al.
(författare)
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A search for an unexpected asymmetry in the production of e+μ− and e−μ+ pairs in proton–proton collisions recorded by the ATLAS detector at √s = 13 TeV
- 2022
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 830
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Tidskriftsartikel (refereegranskat)abstract
- This search, a type not previously performed at ATLAS, uses a comparison of the production cross sections for e+μ− and e−μ+ pairs to constrain physics processes beyond the Standard Model. It uses 139fb−1 of proton–proton collision data recorded at √s=13 TeV at the LHC. Targeting sources of new physics which prefer final states containing e+μ− to e−μ+, the search contains two broad signal regions which are used to provide model-independent constraints on the ratio of cross sections at the 2% level. The search also has two special selections targeting supersymmetric models and leptoquark signatures. Observations using one of these selections are able to exclude, at 95% confidence level, singly produced smuons with masses up to 640 GeV in a model in which the only other light sparticle is a neutralino when the R-parity-violating coupling λ231′ is close to unity. Observations using the other selection exclude scalar leptoquarks with masses below 1880 GeV when geu1R=gμc1R=1, at 95% confidence level. The limit on the coupling reduces to geu1R=gμc1R=0.46 for a mass of 1420 GeV.
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