SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Floreani Annarosa) ;pers:(Milkiewicz Piotr)"

Search: WFRF:(Floreani Annarosa) > Milkiewicz Piotr

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Bergquist, Annika, et al. (author)
  • Impact on follow-up strategies in patients with primary sclerosing cholangitis
  • 2023
  • In: Liver international (Print). - Chichester, United Kingdom : Wiley-Blackwell Publishing Inc.. - 1478-3223 .- 1478-3231. ; 43:1, s. 127-138
  • Journal article (peer-reviewed)abstract
    • BACKGROUND & AIMS: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in PSC with the hypothesis that regular imaging improves survival.METHODS: We collected retrospective data from 2,975 PSC patients from 27 centers. Patients were followed from the start of scheduled imaging or in case of clinical follow-up from January 1, 2000, until death or last clinical follow-up alive. The primary endpoint was all-cause mortality.RESULTS: A broad variety of different follow-up strategies were reported. All except one center used regular imaging, ultrasound (US) and/or magnetic resonance imaging (MRI). Two centers used scheduled ERCP in addition to imaging for surveillance purposes. The overall HR (CI95%) for death, adjusted for sex, age and start year of follow-up, were 0.61 (0.47-0.80) for scheduled imaging with and without ERCP; 0.64 (0.48-0.86) for US/MRI and 0.53 (0.37-0.75) for follow-up strategies including scheduled ERCP. The lower risk of death remained for scheduled imaging with and without ERCP after adjustment for cholangiocarcinoma (CCA) or high-grade dysplasia as a time-dependent covariate, HR 0.57 (0.44-0.75). Hepatobiliary malignancy was diagnosed in 175 (5.9%) of the patients at 7.9 years follow-up. Asymptomatic patients (25%) with CCA had better survival if scheduled imaging had been performed.CONCLUSIONS: Follow-up strategies vary considerably across centers. Scheduled imaging was associated with improved survival. Multiple factors may contribute to this result including early tumor detection and increased endoscopic treatment of asymptomatic benign biliary strictures.
  •  
2.
  • Liu, Jimmy Z, et al. (author)
  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
  • 2013
  • In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:6, s. 670-5
  • Journal article (peer-reviewed)abstract
    • Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Bergquist, Annika (2)
Färkkilä, Martti (2)
Floreani, Annarosa (2)
Weismüller, Tobias J ... (2)
Milkiewicz, Piot... (2)Undo refine
Schramm, Christoph (2)
show more...
Nilsson, Emma (1)
Marschall, Hanns-Ulr ... (1)
Andreassen, Ole A (1)
Karlsen, Tom H (1)
Boberg, Kirsten Muri (1)
Isoniemi, Helena (1)
Rorsman, Fredrik, Do ... (1)
Werner, Mårten (1)
Padyukov, Leonid (1)
Albrecht, Mario (1)
Arola, Johanna (1)
Herms, Stefan (1)
Nöthen, Markus M (1)
Nyhlin, Nils, 1971- (1)
Vermeire, Severine (1)
Invernizzi, Pietro (1)
Rich, Stephen S (1)
Wijmenga, Cisca (1)
Rioux, John D. (1)
Schreiber, Stefan (1)
Hveem, Kristian (1)
Söderling, Jonas (1)
Kechagias, Stergios, ... (1)
Saarela, Janna (1)
Franke, Andre (1)
Winkelmann, Juliane (1)
Björnsson, Einar, 19 ... (1)
Schork, Andrew J (1)
Levy, Cynthia (1)
Rupp, Christian (1)
Joshi, Deepak (1)
Nayagam, Jeremy Shan ... (1)
Montano-Loza, Aldo J ... (1)
Lytvyak, Ellina (1)
Wunsch, Ewa (1)
Zenouzi, Roman (1)
Cazzagon, Nora (1)
Friis Liby, Ingalill (1)
Wiestler, Miriam (1)
Wedemeyer, Heiner (1)
Zhou, Taotao (1)
Strassburg, Christia ... (1)
Rigopoulou, Eirini (1)
Dalekos, George (1)
show less...
University
Karolinska Institutet  (2)Undo refine
University of Gothenburg (1)
Umeå University (1)
Uppsala University (1)
Örebro University (1)
Linköping University (1)
show more...
Lund University (1)
show less...
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view