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Distinct cell-speci...
Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.
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Brownlie, Rebecca J (author)
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Lawlor, Kate E (author)
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Niederer, Heather A (author)
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Cutler, Antony J (author)
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- Xiang, Zou (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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Clatworthy, Menna R (author)
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Floto, R Andres (author)
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Greaves, David R (author)
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Lyons, Paul A (author)
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Smith, Kenneth G C (author)
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(creator_code:org_t)
- 2008-03-24
- 2008
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 205:4, s. 883-95
- Related links:
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http://jem.rupress.o...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Animals
- Antigens
- CD
- immunology
- Antigens
- CD86
- immunology
- Arthritis
- Experimental
- Autoimmunity
- immunology
- B-Lymphocytes
- cytology
- enzymology
- Bacterial Infections
- Cell Proliferation
- Extracellular Signal-Regulated MAP Kinases
- metabolism
- Humans
- Immunoglobulin G
- immunology
- Infection
- immunology
- Lupus Erythematosus
- Systemic
- immunology
- Macrophages
- immunology
- Mice
- Mice
- Transgenic
- Organ Specificity
- Phosphorylation
- Receptors
- IgG
- immunology
- T-Lymphocytes
- immunology
- Transgenes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brownlie, Rebecc ...
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Lawlor, Kate E
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Niederer, Heathe ...
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Cutler, Antony J
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Xiang, Zou
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Clatworthy, Menn ...
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show more...
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Floto, R Andres
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Greaves, David R
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Lyons, Paul A
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Smith, Kenneth G ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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The Journal of e ...
- By the university
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University of Gothenburg