Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.

• FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Keyword

Animals

Antigens

CD

immunology

Antigens

CD86

immunology

Arthritis

Experimental

Autoimmunity

immunology

B-Lymphocytes

cytology

enzymology

Bacterial Infections

Cell Proliferation

Extracellular Signal-Regulated MAP Kinases

metabolism

Humans

Immunoglobulin G

immunology

Infection

immunology

Lupus Erythematosus

Systemic

immunology

Macrophages

immunology

Mice

Mice

Transgenic

Organ Specificity

Phosphorylation

Receptors

IgG

immunology

T-Lymphocytes

immunology

Transgenes

Publication and Content Type

ref (subject category)

art (subject category)