| 1. |
- Hansson, Erik, 1983-, et al.
(författare)
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A Quantitative Comparison of PRAM based Emulated Shared Memory Architectures to Current Multicore CPUs and GPUs
- 2014
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Ingår i: 27th International Conference on Architecture of Computing Systems (ARCS), 2014, ARCS Workshops: Proc. PASA-2014 11th Workshop on Parallel Systems and Algorithms, Lübeck, Germany. - Lübeck, Germany : VDE Verlag GmbH. - 9783800735792 ; , s. 27-33
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Konferensbidrag (refereegranskat)abstract
- The performance of current multicore CPUs and GPUs is limited in computations making frequent use of communication/synchronization between the subtasks executed in parallel. This is because the directory-based cache systems scale weakly and/or the cost of synchronization is high. The Emulated Shared Memory (ESM) architectures relying on multithreading and efficient synchronization mechanisms have been developed to solve these problems affecting both performance and programmability of current machines. In this paper, we compare preliminarily the performance of three hardware implemented ESM architectures with state-of-the-art multicore CPUs and GPUs. The benchmarks are selected to cover different patterns of parallel computation and therefore reveal the performance potential of ESM architectures with respect to current multicores.
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| 2. |
- Karyotaki, Eirini, et al.
(författare)
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Internet-Based Cognitive Behavioral Therapy for Depression : A Systematic Review and Individual Patient Data Network Meta-analysis
- 2021
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Ingår i: JAMA psychiatry. - : American Medical Association. - 2168-6238 .- 2168-622X. ; 78:4, s. 361-371
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Forskningsöversikt (refereegranskat)abstract
- IMPORTANCE: Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them.OBJECTIVE: To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information.DATA SOURCES: We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019.STUDY SELECTION: Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization.DATA EXTRACTION AND SYNTHESIS: We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression.MAIN OUTCOMES AND MEASURES: Patient Health Questionnaire-9 (PHQ-9) scores.RESULTS: Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, -0.8; 95% CI, -1.4 to -0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshold depression (PHQ-9 scores 5-9) were small, while guided iCBT was associated with overall better outcomes in patients with baseline PHQ-9 greater than 9.CONCLUSIONS AND RELEVANCE: In this network meta-analysis with IPD, guided iCBT was associated with more effectiveness than unguided iCBT for individuals with depression, benefits were more substantial in individuals with moderate to severe depression. Unguided iCBT was associated with similar effectiveness among individuals with symptoms of mild/subthreshold depression. Personalized treatment selection is entirely possible and necessary to ensure the best allocation of treatment resources for depression.
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| 3. |
- Forsell, Erik, et al.
(författare)
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Proof of Concept for an Adaptive Treatment Strategy to Prevent Failures in Internet-Delivered CBT : A Single-Blind Randomized Clinical Trial With Insomnia Patients
- 2019
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Ingår i: American Journal of Psychiatry. - : American Psychiatric Association Publishing. - 0002-953X .- 1535-7228. ; 176:4, s. 315-323
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study aimed to demonstrate proof of concept for an adaptive treatment strategy in Internet-delivered cognitive-behavioral therapy (ICBT), where risk of treatment failure is assessed early in treatment and treatment for at-risk patients is adapted to prevent treatment failure. Methods: A semiautomated algorithm assessed risk of treatment failure early in treatment in 251 patients undergoing ICBT for insomnia with therapist guidance. At-risk patients were randomly assigned to continue standard ICBT or to receive adapted ICBT. The primary outcome was self-rated insomnia symptoms using the Insomnia Severity Index in a linear mixed-effects model. The main secondary outcome was treatment failure (having neither responded nor remitted at the posttreatment assessment). Results: A total of 102 patients were classified as at risk and randomly assigned to receive adapted ICBT (N=51) or standard ICBT (N=51); 149 patients were classified as not at risk. Patients not at risk had significantly greater score reductions on the Insomnia Severity Index than at-risk patients given standard ICBT. Adapted ICBT for at-risk patients was significantly more successful in reducing symptoms compared with standard ICBT, and it decreased the risk of failing treatment (odds ratio= 0.33). At-risk patients receiving adapted ICBT were not more likely to experience treatment failure than those not at risk (odds ratio= 0.51), though they were less likely to experience remission. Adapted treatment required, on average, 14 more minutes of therapist-patient time per remaining week. Conclusions: An adaptive treatment strategy can increase treatment effects for at-risk patients and reduce the number of failed treatments. Future studies should improve accuracy in classification algorithms and identify key factors that boost the effect of adapted treatments.
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| 4. |
- Forsell, Martti, et al.
(författare)
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Hardware and Software Support for NUMA Computing on Configurable Emulated Shared Memory Architectures
- 2013
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Ingår i: 2013 IEEE 27th International Parallel and Distributed Processing Symposium Workshops & PhD Forum (IPDPSW). - : IEEE conference proceedings. - 9780769549798 ; , s. 640-647
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Konferensbidrag (refereegranskat)abstract
- The emulated shared memory (ESM) architectures are good candidates for future general purpose parallel computers due to their ability to provide easy-to-use explicitly parallel synchronous model of computation to programmers as well as avoid most performance bottlenecks present in current multicore architectures. In order to achieve full performance the applications must, however, have enough thread-level parallelism (TLP). To solve this problem, in our earlier work we have introduced a class of configurable emulated shared memory (CESM) machines that provides a special non-uniform memory access (NUMA) mode for situations where TLP is limited or for direct compatibility for legacy code sequential computing or NUMA mechanism. Unfortunately the earlier proposed CESM architecture does not integrate the different modes of the architecture well together e.g. by leaving the memories for different modes isolated and therefore the programming interface is non-integrated. In this paper we propose a number of hardware and software techniques to support NUMA computing in CESM architectures in a seamless way. The hardware techniques include three different NUMA-shared memory access mechanisms and the software ones provide a mechanism to integrate NUMA computation into the standard parallel random access machine (PRAM) operation of the CESM. The hardware techniques are evaluated on our REPLICA CESM architecture and compared to an ideal CESM machine making use of the proposed software techniques.
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| 5. |
- Forsell, Martti, et al.
(författare)
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NUMA Computing with Hardware and Software Co-Support on Configurable Emulated Shared Memory Architectures
- 2014
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Ingår i: International Journal of Networking and Computing. - 2185-2839 .- 2185-2847. ; 4:1, s. 189-206
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Tidskriftsartikel (refereegranskat)abstract
- The emulated shared memory (ESM) architectures are good candidates for future general purpose parallel computers due to their ability to provide an easy-to-use explicitly parallel synchronous model of computation to programmers as well as avoid most performance bottlenecks present in current multicore architectures. In order to achieve full performance the applications must, however, have enough thread-level parallelism (TLP). To solve this problem, in our earlier work we have introduced a class of configurable emulated shared memory (CESM) machines that provides a special non-uniform memory access (NUMA) mode for situations where TLP is limited or for direct compatibility for legacy code sequential computing and NUMA mechanism. Unfortunately the earlier proposed CESM architecture does not integrate the different modes of the architecture well together e.g. by leaving the memories for different modes isolated and therefore the programming interface is non-integrated. In this paper we propose a number of hardware and software techniques to support NUMA computing in CESM architectures in a seamless way. The hardware techniques include three different NUMA shared memory access mechanisms and the software ones provide a mechanism to integrate and optimize NUMA computation into the standard parallel random access machine (PRAM) operation of the CESM. The hardware techniques are evaluated on our REPLICA CESM architecture and compared to an ideal CESM machine making use of the proposed software techniques.
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| 6. |
- Furukawa, Toshi A., et al.
(författare)
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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression : a systematic review and component network meta-analysis using individual data
- 2021
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Ingår i: Lancet psychiatry. - London, United Kingdom : Elsevier. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511
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Forskningsöversikt (refereegranskat)abstract
- Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
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| 7. |
- Mäkelä, Jari-Matti, et al.
(författare)
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Design of the Language Replica for Hybrid PRAM-NUMA Many-core Architectures
- 2012
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Ingår i: Parallel and Distributed Processing with Applications (ISPA), 2012. - : IEEE conference proceedings. - 9781467316316 ; , s. 697-704
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Konferensbidrag (refereegranskat)abstract
- Parallel programming is widely considered very demanding for an average programmer due to inherent asynchrony of underlying parallel architectures. In this paper we describe the main design principles and core features of Replica -- a parallel language aimed for high-level programming of a new paradigm of reconfigurable, scalable and powerful synchronous shared memory architectures that promise to make parallel programming radically easier with the help of strict memory consistency and deterministic synchronous execution of hardware threads and multi-operations.
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| 8. |
- Rozental, Alexander, et al.
(författare)
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Differentiating procrastinators from each other : A cluster analysis
- 2015
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Ingår i: Cognitive Behaviour Therapy. - : Informa UK Limited. - 1650-6073 .- 1651-2316. ; 44:6, s. 480-490
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Tidskriftsartikel (refereegranskat)abstract
- Procrastination refers to the tendency to postpone the initiation and completion of a given course of action. Approximately one-fifth of the adult population and half of the student population perceive themselves as being severe and chronic procrastinators. Albeit not a psychiatric diagnosis, procrastination has been shown to be associated with increased stress and anxiety, exacerbation of illness, and poorer performance in school and work. However, despite being severely debilitating, little is known about the population of procrastinators in terms of possible subgroups, and previous research has mainly investigated procrastination among university students. The current study examined data from a screening process recruiting participants to a randomized controlled trial of Internet-based cognitive behavior therapy for procrastination (Rozental et al., in press). In total, 710 treatment-seeking individuals completed self-report measures of procrastination, depression, anxiety, and quality of life. The results suggest that there might exist five separate subgroups, or clusters, of procrastinators: “Mild procrastinators” (24.93%), “Average procrastinators” (27.89%), “Well-adjusted procrastinators” (13.94%), “Severe procrastinators” (21.69%), and “Primarily depressed” (11.55%). Hence, there seems to be marked differences among procrastinators in terms of levels of severity, as well as a possible subgroup for which procrastinatory problems are primarily related to depression. Tailoring the treatment interventions to the specific procrastination profile of the individual could thus become important, as well as screening for comorbid psychiatric diagnoses in order to target difficulties associated with, for instance, depression.
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| 9. |
- Rozental, Alexander, et al.
(författare)
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Internet-based cognitive behavior therapy for procrastination : A randomized controlled trial
- 2015
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Ingår i: Journal of Consulting and Clinical Psychology. - : American Psychological Association (APA). - 0022-006X .- 1939-2117. ; 83:4, s. 808-824
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Procrastination can be a persistent behavior pattern associated with personal distress. However, research investigating different treatment interventions is scarce, and no randomized controlled trial has examined the efficacy of cognitive−behavior therapy (CBT). Meanwhile, Internet-based CBT has been found promising for several conditions, but has not yet been used for procrastination. Method: Participants (N = 150) were randomized to guided self-help, unguided self-help, and wait-list control. Outcome measures were administered before and after treatment, or weekly throughout the treatment period. They included the Pure Procrastination Scale, the Irrational Procrastination Scale, the Susceptibility to Temptation Scale, the Montgomery Åsberg Depression Rating Scale−Self-report version, the Generalized Anxiety Disorder Assessment, and the Quality of Life Inventory. The intention-to-treat principle was used for all statistical analyses. Results: Mixed-effects models revealed moderate between-groups effect sizes comparing guided and unguided self-help with wait-list control; the Pure Procrastination Scale, Cohen’s d = 0.70, 95% confidence interval (CI) [0.29, 1.10], and d = 0.50, 95% CI [0.10, 0.90], and the Irrational Procrastination Scale, d = 0.81 95% CI [0.40, 1.22], and d = 0.69 95% CI [0.29, 1.09]. Clinically significant change was achieved among 31.3–40.0% for guided self-help, compared with 24.0–36.0% for unguided self-help. Neither of the treatment conditions was found to be superior on any of the outcome measures, Fs(98, 65.17−72.55)< 1.70, p >.19. Conclusion: Internet-based CBT could be useful for managing self-reported difficulties due to procrastination, both with and without the guidance of a therapist.
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| 10. |
- Rozental, Alexander, et al.
(författare)
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Overcoming procrastination : one-year follow-up and predictors of change in a randomized controlled trial of Internet-based cognitive behavior therapy
- 2017
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Ingår i: Cognitive Behaviour Therapy. - : Informa UK Limited. - 1650-6073 .- 1651-2316. ; 46:3, s. 177-195
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Tidskriftsartikel (refereegranskat)abstract
- Procrastination is a common self-regulatory failure that can have a negative impact on well-being and performance. However, few clinical trials have been conducted, and no follow-up has ever been performed. The current study therefore aimed to provide evidence for the long-term benefits and investigate predictors of a positive treatment outcome among patients receiving Internet-based cognitive behavior therapy (ICBT). A total of 150 self-recruited participants were randomized to guided or unguided ICBT. Self-report measures of procrastination, depression, anxiety, and quality of life were distributed at pre-treatment assessment, post-treatment assessment, and one-year follow-up. Mixed effects models were used to investigate the long-term gains, and multiple linear regression for predictors of a positive treatment outcome, using the change score on the Irrational Procrastination Scale as the dependent variable. Intention-to-treat was implemented for all statistical analyses. Large within-group effect sizes for guided and unguided ICBT, Cohen’s d = .97–1.64, were found for self-report measures of procrastination, together with d = .56–.66 for depression and anxiety. Gains were maintained, and, in some cases, improved at follow-up. Guided and unguided ICBT did not differ from each other, mean differences −.31–1.17, 95% CIs [−2.59–3.22], and none of the predictors were associated with a better result, bs −1.45–1.61, 95% CIs [−3.14–4.26]. In sum, ICBT could be useful and beneficial in relation to managing procrastination, yielding great benefits up to one year after the treatment period has ended, with comparable results between guided and unguided ICBT.
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