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- Sumaila, U. Rashid, et al.
(författare)
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WTO must ban harmful fisheries subsidies
- 2021
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Giele, Walter, et al.
(författare)
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The QCD / SM working group: Summary report
- 2002
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Ingår i: Physics at TeV colliders. Proceedings, Euro Summer School, Les Houches, France, May 21-June 1, 2001. ; , s. 275-426, s. 275-426
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Herrera-Rivero, Marisol, et al.
(författare)
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Exploring the genetics of lithium response in bipolar disorders.
- 2023
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Ingår i: Research square.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N=2,064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II.We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism.Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.
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- Niklaus, Frank, et al.
(författare)
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Wafer-Level 3D Integration Technology Platforms for ICs and MEMS
- 2005
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Ingår i: TWENTY SECOND INTERNATIONAL VLSI MULTILEVEL INTERCONNECTION (VMIC). ; , s. 486-493
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Wafer-level three-dimensional (3D) integration is an emerging technology to increase theperformance and functionality of integrated circuits (ICs) and microelectromechanical systems(MEMS). In ICs, wafer-level 3D integration based on wafer bonding offers the potential for a highdensity of micron-sized through-die vias necessary for highest performance memory stacks,microprocessors with large L2 caches and ASICs with large embedded memories. In MEMS devices,wafer-level 3D integration based on wafer bonding offers the potential for integrating highperformance transducer materials such as various monocrystalline semiconductor materials withelectronic circuits for arrayed, highly integrated sensor and actuator components. This invited paperpresents an overview of current wafer-level 3D integration platforms that use wafer bonding withpolymer adhesives for ICs and MEMS applications.
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- Shebanits, Oleg, 1984-, et al.
(författare)
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On Ion Drifts and Neutral Winds in Titan’s Thermosphere
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Saturn’s largest moon Titan hosts an atmosphere with complex organic chemistry initiated partly in the ionosphere. The nightside chemistry may be influenced by the ion transport from the dayside ionosphere. In turn, ion transport (ion drifts) may be affected by the neutral winds, which cannot be measured directly by Cassini. In this study we derive the ion drifts along the spacecraft trajectories based on analysis of in-situ measurements of electron and ion fluxes, mean masses of positive and negative ions and the magnetic field. Data from Titan flybys TA to T100 (Oct 2005 - Apr 2014) is included in this study, 55 flybys are below 1400 km and 48 are below 1200 km altitude. Based on the measurements, three regions of the ionosphere were defined by altitude: 1) above 1600 km, ions are ?×?-drifting (frozen into the magnetic field), 2) 1100-1600 km, dynamo-region, ions drift partly in opposite directions (perpendicular to B) and 3) below 1100 km (upper limit depends on convection electric field strength), ions are following neutrals.
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