| 1. |
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| 2. |
- Lundberg, C, et al.
(author)
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Dementia and driving: an attempt at consensus
- 1997
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In: Alzheimer disease and associated disorders. - : Ovid Technologies (Wolters Kluwer Health). - 0893-0341. ; 11:1, s. 28-37
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Journal article (peer-reviewed)
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| 3. |
- Amole, C., et al.
(author)
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Experimental and computational study of the injection of antiprotons into a positron plasma for antihydrogen production
- 2013
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In: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 20:4, s. 043510-
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Journal article (peer-reviewed)abstract
- One of the goals of synthesizing and trapping antihydrogen is to study the validity of charge-parity-time symmetry through precision spectroscopy on the anti-atoms, but the trapping yield achieved in recent experiments must be significantly improved before this can be realized. Antihydrogen atoms are commonly produced by mixing antiprotons and positrons stored in a nested Penning-Malmberg trap, which was achieved in ALPHA by an autoresonant excitation of the antiprotons, injecting them into the positron plasma. In this work, a hybrid numerical model is developed to simulate antiproton and positron dynamics during the mixing process. The simulation is benchmarked against other numerical and analytic models, as well as experimental measurements. The autoresonant injection scheme and an alternative scheme are compared numerically over a range of plasma parameters which can be reached in current and upcoming antihydrogen experiments, and the latter scheme is seen to offer significant improvement in trapping yield as the number of available antiprotons increases.
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| 4. |
- Borroto-Escuela, DO, et al.
(author)
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Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
- 2016
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In: Therapeutic advances in psychopharmacology. - : SAGE Publications. - 2045-1253 .- 2045-1261. ; 6:2, s. 77-94
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Journal article (peer-reviewed)abstract
- The dopamine (DA) neuron system most relevant for schizophrenia is the meso-limbic-cortical DA system inter alia densely innervating subcortical limbic regions. The field of dopamine D2 receptors and schizophrenia changed markedly with the discovery of many types of D2 heteroreceptor complexes in subcortical limbic areas as well as the dorsal striatum. The results indicate that the D2 is a hub receptor which interacts not only with many other G protein-coupled receptors (GPCRs) including DA isoreceptors but also with ion-channel receptors, receptor tyrosine kinases, scaffolding proteins and DA transporters. Disturbances in several of these D2 heteroreceptor complexes may contribute to the development of schizophrenia through changes in the balance of diverse D2 homo- and heteroreceptor complexes mediating the DA signal, especially to the ventral striato-pallidal γ-aminobutyric acid (GABA) pathway. This will have consequences for the control of this pathway of the glutamate drive to the prefrontal cortex via the mediodorsal thalamic nucleus which can contribute to psychotic processes. Agonist activation of the A2A protomer in the A2A–D2 heteroreceptor complex inhibits D2 Gi/o mediated signaling but increases the D2 β-arrestin2 mediated signaling. Through this allosteric receptor–receptor interaction, the A2A agonist becomes a biased inhibitory modulator of the Gi/o mediated D2 signaling, which may the main mechanism for its atypical antipsychotic properties especially linked to the limbic A2A–D2 heterocomplexes. The DA and glutamate hypotheses of schizophrenia come together in the signal integration in D2– N-methyl-d-aspartate (NMDA) and A2A–D2–metabotropic glutamate receptor 5 (mGlu5) heteroreceptor complexes, especially in the ventral striatum. 5-Hydroxytryptamine 2A (5-HT2A)–D2 heteroreceptor complexes are special targets for atypical antipsychotics with high potency to block their 5-HT2A protomer signaling in view of the potential development of pathological allosteric facilitatory 5-HT2A–D2 interaction increasing D2 protomer signaling. Neurotensin (NTS1)–D2 heterocomplexes also exist in the ventral and dorsal striatum, and likely also in midbrain DA nerve cells as NTS1-D2 autoreceptor complexes where neurotensin produces antipsychotic and propsychotic actions, respectively.
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| 5. |
- Muduli, Pranaba, et al.
(author)
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Composition dependent properties of Fe3Si films grown on GaAs(113)A substrates
- 2009
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In: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 105:7, s. 07B104-
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Journal article (peer-reviewed)abstract
- Structural, electrical, and magnetic properties of Fe3Si/GaAs(113)A hybrid structures are studied, dependent on the layer composition varying from 15 to 26 at. % Si. The presence of superlattice reflections in x-ray diffraction and lower resistivity confirms the long-range atomic ordering in the stoichiometric Fe3Si films, reflecting the D0(3) crystal structure. The observed atomic ordering is also found to influence the sign and magnitude of the antisymmetric component of the planar Hall effect observed in this orientation. However a finite disorder is observed even in nearly stoichiometric samples.
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| 6. |
- Plach, M, et al.
(author)
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Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling
- 2019
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 16312-
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Journal article (peer-reviewed)abstract
- Proceeding investigations of G protein-coupled receptor (GPCR) heterocomplexes have demonstrated that the dopamine D2 receptor (D2R), one of the hub receptors in the physiology of schizophrenia, interacts with both the neurotensin NTS1 (NTS1R) and the serotonin 5-HT2A receptor (5-HT2AR) in cell lines and rodent brain tissue. In situ proximity ligation assay and BRET-based saturation experiments confirmed interacting receptor assemblies in HEK293T and neuronal HT22 cells. The NTS1R agonist NT(8-13) reduces the Gαq-mediated calcium signal in the NTS1R-D2R complex compared to the NTS1R monomer which could be reversed by D2R antagonists. The bivalent ligand CS148 (NTS1R-agonistic, D2R-antagonistic) increased the calcium response addressing the dimer, consistent with the effect of the monovalent ligands suggesting an allosteric D2R-mediated modulation. In contrast, the 5-HT2AR-D2R heteromer did not show a calcium-altering receptor-receptor interaction. Despite their common coupling-preference for Gαq, 5-HT2AR and NTS1R supposedly interact with D2R each in a unique mode. This remarkably diverse ligand-mediated signalling in two different D2R heteroreceptor complexes illustrates the complexity of receptor-receptor interactions and their potential of modifying cell responses to external stimuli. Therefore, GPCR heteromers may provide a very promising novel target for the therapy of neuropsychiatric disorders.
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| 7. |
- Anchordoqui, Luis A., et al.
(author)
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The Forward Physics Facility : Sites, experiments, and physics potential
- 2022
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In: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 968, s. 1-50
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Journal article (peer-reviewed)abstract
- The Forward Physics Facility (FPF) is a proposal to create a cavern with the space and infrastructure to support a suite of far-forward experiments at the Large Hadron Collider during the High Luminosity era. Located along the beam collision axis and shielded from the interaction point by at least 100 m of concrete and rock, the FPF will house experiments that will detect particles outside the acceptance of the existing large LHC experiments and will observe rare and exotic processes in an extremely low-background environment. In this work, we summarize the current status of plans for the FPF, including recent progress in civil engineering in identifying promising sites for the FPF and the experiments currently envisioned to realize the FPF's physics potential. We then review the many Standard Model and new physics topics that will be advanced by the FPF, including searches for long-lived particles, probes of dark matter and dark sectors, high-statistics studies of TeV neutrinos of all three flavors, aspects of perturbative and non-perturbative QCD, and high-energy astroparticle physics.
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| 8. |
- Friedland, S., et al.
(author)
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On the Validations of the Asymptotic Matching Conjectures
- 2008
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In: Journal of statistical physics. - : Springer Science and Business Media LLC. - 0022-4715 .- 1572-9613. ; 133:3, s. 513-533
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Journal article (peer-reviewed)abstract
- In this paper we review the asymptotic matching conjectures for r-regular bipartite graphs, and their connections in estimating the monomer-dimer entropies in d-dimensional integer lattice and Bethe lattices. We prove new rigorous upper and lower bounds for the monomer-dimer entropies, which support these conjectures. We describe a general construction of infinite families of r-regular tori graphs and give algorithms for computing the monomer-dimer entropy of density p, for any p is an element of[0,1], for these graphs. Finally we use tori graphs to test the asymptotic matching conjectures for certain infinite r-regular bipartite graphs.
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| 9. |
- Hargreaves, S, et al.
(author)
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Multidrug-resistant tuberculosis and migration to Europe
- 2017
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In: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. - : Elsevier BV. - 1469-0691. ; 23:3, s. 141-146
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Journal article (peer-reviewed)
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| 10. |
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