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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Huang, DL, et al.
(författare)
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Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5850-
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Tidskriftsartikel (refereegranskat)abstract
- HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody genes can be engineered into B cells for expression as both a functional antigen receptor on cell surfaces and as secreted antibody. Here, we show that HIV bnAb-engineered primary mouse B cells can be adoptively transferred and vaccinated in immunocompetent mice resulting in the expansion of durable bnAb memory and long-lived plasma cells. Somatic hypermutation after immunization indicates that engineered cells have the capacity to respond to an evolving pathogen. These results encourage further exploration of engineered B cell vaccines as a strategy for durable elicitation of HIV bnAbs to protect against infection and as a contributor to a functional HIV cure.
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- Lewis, CA, et al.
(författare)
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Considerations of scale in habitat conservation and restoration
- 1996
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Ingår i: CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES. - : NATL RESEARCH COUNCIL CANADA. - 0706-652X. ; 53, s. 440-445
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Space and time function together to shape communities and ecosystems. As a result, the definition of scale of observation is critical to the design of successful habitat conservation and restoration strategies. Traditionally, aquatic habitat studies were
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