| 1. |
- Tabiri, S, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 2. |
- Bravo, L, et al.
(författare)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Khatri, C, et al.
(författare)
-
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
-
Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
-
Tidskriftsartikel (refereegranskat)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
|
|
| 4. |
- Hawash, Hamada B., et al.
(författare)
-
Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations
- 2023
-
Ingår i: Journal of Water Process Engineering. - : Elsevier. - 2214-7144. ; 52
-
Forskningsöversikt (refereegranskat)abstract
- Pharmaceuticals and personal care products (PPCPs) residues are known to occur widely in the aquatic environments of industrialized and developing countries. Considerable progress has been made regarding to study of their exposure and distribution in aquatic environment. The spatial distribution and transformation of PPCPs have been investigated in the aquatic systems of different countries covering the five UN regions. As a result, the objectives of this review are focused on: (a) the global occurrence of PPCPs residues in aquatic systems, particularly in drinking/tap water, surface water, groundwater, and wastewater treatment plants (WWTPs), (b) widely prescribed pharmaceutical classes such as antibiotics, antidepressants, β-blockers, lipid regulators, nonsteroidal anti-inflammatory drugs (NSAIDs), etc. due to their potential adverse influences on the aquatic ecosystems and human health, (c) the spatial distribution of PPCPs in water bodies based on recently published data, (d) different regions in the world (e.g., USA, China, and Mediterranean basin) as case studies of contaminated areas, (e) the relation of occurrences with specific characteristics of frequently detected compounds, (f) the legislation and regulations implemented by countries/states governments were summarized and discussed, and finally, (g) future perspectives for research on PPCPs in the aquatic environment, which are explained regarded to the research gaps in current knowledge. The findings of this review indicate that the concentrations of PPCPs in the influents and effluents of WWTPs of the selected regions are much higher than in other water matrices. Additionally, there are significant variations in PPCPs concentrations between different countries and regions due to certain reasons.
|
|
