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Combined associations of a polygenic risk score and classical risk factors with breast cancer risk

Kapoor, Pooja Middha (author)
Mavaddat, Nasim (author)
Choudhury, Parichoy Pal (author)
show more...
Wilcox, Amber N. (author)
Lindström, Sara (author)
Behrens, Sabine (author)
Michailidou, Kyriaki (author)
Dennis, Joe (author)
Bolla, Manjeet K. (author)
Wang, Qin (author)
Jung, Audrey (author)
Abu-Ful, Zomoroda (author)
Ahearn, Thomas (author)
Andrulis, Irene L. (author)
Anton-Culver, Hoda (author)
Arndt, Volker (author)
Aronson, Kristan J. (author)
Auer, Paul L. (author)
Beane Freeman, Laura E. (author)
Becher, Heiko (author)
Beckmann, Matthias W. (author)
Beeghly-Fadiel, Alicia (author)
Benitez, Javier (author)
Bernstein, Leslie (author)
Bojesen, Stig E. (author)
Brauch, Hiltrud (author)
Brenner, Hermann (author)
Brüning, Thomas (author)
Cai, Qiuyin (author)
Campa, Daniele (author)
Canzian, Federico (author)
Carracedo, Angel (author)
Carter, Brian D. (author)
Castelao, Jose E. (author)
Chanock, Stephen J. (author)
Chatterjee, Nilanjan (author)
Chenevix-Trench, Georgia (author)
Clarke, Christine L. (author)
Couch, Fergus J. (author)
Cox, Angela (author)
Cross, Simon S. (author)
Czene, Kamila (author)
Karolinska Institutet
Dai, James Y. (author)
Earp, H. Shelton (author)
Ekici, Arif B. (author)
Eliassen, A. Heather (author)
Eriksson, Mikael (author)
Karolinska Institutet
Evans, D. Gareth (author)
Fasching, Peter A. (author)
Figueroa, Jonine (author)
Fritschi, Lin (author)
Gabrielson, Marike (author)
Karolinska Institutet
Gago-Dominguez, Manuela (author)
Gao, Chi (author)
Gapstur, Susan M. (author)
Gaudet, Mia M. (author)
Giles, Graham G. (author)
González-Neira, Anna (author)
Guénel, Pascal (author)
Haeberle, Lothar (author)
Haiman, Christopher A. (author)
Håkansson, Niclas (author)
Karolinska Institutet
Hall, Per (author)
Karolinska Institutet
Hamann, Ute (author)
Hatse, Sigrid (author)
Heyworth, Jane (author)
Holleczek, Bernd (author)
Hoover, Robert N. (author)
Hopper, John L. (author)
Howell, Anthony (author)
Hunter, David J. (author)
John, Esther M. (author)
Jones, Michael E. (author)
Kaaks, Rudolf (author)
Keeman, Renske (author)
Kitahara, Cari M. (author)
Ko, Yon-Dschun (author)
Koutros, Stella (author)
Kurian, Allison W. (author)
Karolinska Institutet
Lambrechts, Diether (author)
Le Marchand, Loic (author)
Lee, Eunjung (author)
Lejbkowicz, Flavio (author)
Linet, Martha (author)
Lissowska, Jolanta (author)
Llaneza, Ana (author)
MacInnis, Robert J. (author)
Martinez, Maria Elena (author)
Maurer, Tabea (author)
McLean, Catriona (author)
Neuhausen, Susan L. (author)
Newman, William G. (author)
Norman, Aaron (author)
O'Brien, Katie M. (author)
Olshan, Andrew F. (author)
Olson, Janet E. (author)
Olsson, Håkan (author)
Orr, Nick (author)
Perou, Charles M. (author)
Pita, Guillermo (author)
Polley, Eric C. (author)
Prentice, Ross L. (author)
Rennert, Gad (author)
Rennert, Hedy S. (author)
Ruddy, Kathryn J. (author)
Sandler, Dale P. (author)
Saunders, Christobel (author)
Schoemaker, Minouk J. (author)
Schöttker, Ben (author)
Schumacher, Fredrick (author)
Scott, Christopher (author)
Scott, Rodney J. (author)
Shu, Xiao-Ou (author)
Smeets, Ann (author)
Southey, Melissa C. (author)
Spinelli, John J. (author)
Stone, Jennifer (author)
Swerdlow, Anthony J. (author)
Tamimi, Rulla M. (author)
Taylor, Jack A. (author)
Troester, Melissa A. (author)
Vachon, Celine M. (author)
van Veen, Elke M. (author)
Wang, Xiaoliang (author)
Weinberg, Clarice R. (author)
Weltens, Caroline (author)
Willett, Walter (author)
Winham, Stacey J. (author)
Wolk, Alicja (author)
Uppsala universitet,Medicinsk epidemiologi,Karolinska institutet
Yang, Xiaohong R. (author)
Zheng, Wei (author)
Ziogas, Argyrios (author)
Dunning, Alison M. (author)
Pharoah, Paul D. P. (author)
Schmidt, Marjanka K. (author)
Kraft, Peter (author)
Easton, Douglas F. (author)
Milne, Roger L. (author)
García-Closas, Montserrat (author)
Chang-Claude, Jenny (author)
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 (creator_code:org_t)
2020-05-02
2021
English.
In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 113:3, s. 329-337
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression and a newly developed case-only method for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history) and, on average, 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer. 

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

Breast cancer
Epidemiology
Gene-environment interactions
Genetic susceptibility
Polygenic risk score
Risk factors
Risk prediction

Publication and Content Type

ref (subject category)
art (subject category)

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McLean, Catriona
Neuhausen, Susan ...
Newman, William ...
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O'Brien, Katie M ...
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Olsson, Håkan
Orr, Nick
Perou, Charles M ...
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Polley, Eric C.
Prentice, Ross L ...
Rennert, Gad
Rennert, Hedy S.
Ruddy, Kathryn J ...
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Schumacher, Fred ...
Scott, Christoph ...
Scott, Rodney J.
Shu, Xiao-Ou
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Southey, Melissa ...
Spinelli, John J ...
Stone, Jennifer
Swerdlow, Anthon ...
Tamimi, Rulla M.
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Troester, Meliss ...
Vachon, Celine M ...
van Veen, Elke M ...
Wang, Xiaoliang
Weinberg, Claric ...
Weltens, Carolin ...
Willett, Walter
Winham, Stacey J ...
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Zheng, Wei
Ziogas, Argyrios
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MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Journal of the N ...
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Uppsala University
Karolinska Institutet

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