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Sökning: WFRF:(Giacomelli Luca)

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  • Andersson Sundén, Erik, et al. (författare)
  • Instrumentation for neutron emission spectrometry in use at JET
  • 2010
  • Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 623:2, s. 681-685
  • Tidskriftsartikel (refereegranskat)abstract
    • The present contribution discusses two neutron spectrometers: the time-of-flight spectrometer (TOFOR) and the magnetic proton recoil spectrometer (MPRu). TOFOR uses fast plastic scintillators equipped with digital time-stamping electronics to register the time of each eligible scintillation event. The time trace for each detector is acquired practically dead-time free. The detectors of the MPRu are of phoswich type and each detector is connected to a digital transient recorder card that stores the full waveform for an event. By using phoswich detectors, pulse-shape discrimination techniques can be applied offline to distinguish signal events from background. A future upgrade of TOFOR could be digital “hybrid” cards, which store correlated time and waveform information. This information can be used to decrease the background level in the ttof spectrum, thereby increasing the operating range.
  • Belli, Francesco, et al. (författare)
  • Conceptual Design, Development and Preliminary Tests of a Compact Neutron Spectrometer for the JET Experiment
  • 2012
  • Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 59:5, s. 2512-2519
  • Tidskriftsartikel (refereegranskat)abstract
    • A Compact Neutron Spectrometer (CNS) has been developed to measure the neutron emission spectra in Joint European Torus (JET) fusion plasma experiments. The spectrometer, based on a liquid scintillation detector (BC501A), is equipped with a Digital Pulse Shape Discrimination (DPSD) acquisition system for neutron (n) and gamma-ray(gamma) separation. The CNS enables recording the n and gamma pulse height spectra (PHS) up to total count rates of similar to 10(6) s(-1). Energy resolution, after PHS unfolding, will be <2% for 14 MeV neutrons and <4% for 2.5 MeV neutrons. The work done by ENEA-Frascati and Physikalisch-Technische Bundesanstalt (PTB) respectively in the assembly and test of DPSD and scintillation detector, along with the first results obtained by the spectrometer in JET plasma experiments are presented. The experience obtained with CNS in JET will contribute to the development of neutron spectrometers suitable for applications in the International Thermonuclear Experimental Reactor (ITER).
  • Brito-Zeron, Pilar, et al. (författare)
  • Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren’s syndrome
  • 2019
  • Ingår i: Rheumatology. - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 59:9, s. 2350-2359
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To characterize the systemic phenotype of primary Sjögren’s syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores.Methods: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren’s syndrome from the five continents.Results: The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ≥1). Males had a higher mean ESSDAI (8.1 vs 6.0, P < 0.001) compared with females, as did patients diagnosed at <35 years (6.7 vs 5.6 in patients diagnosed at >65 years, P < 0.001). The highest global ESSDAI score was reported in Black/African Americans, followed by White, Asian and Hispanic patients (6.7, 6.5, 5.4 and 4.8, respectively; P < 0.001). The frequency of involvement of each systemic organ also differed between ethnic groups, with Black/African American patients showing the highest frequencies in the lymphadenopathy, articular, peripheral nervous system, CNS and biological domains, White patients in the glandular, cutaneous and muscular domains, Asian patients in the pulmonary, renal and haematological domains and Hispanic patients in the constitutional domain. Systemic activity measured by the ESSDAI, clinical ESSDAI (clinESSDAI) and disease activity states was higher in patients from southern countries (P < 0.001).Conclusion: The systemic phenotype of primary Sjögren’s syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis. 
  • Brito-Zerón, Pilar, et al. (författare)
  • Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : a cross-sectional study from the Big Data Sjögren Project Consortium
  • 2017
  • Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 76:6, s. 1042-1050
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed.RESULTS: We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African-American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69).CONCLUSIONS: This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.
  • Eriksson, Jacob, et al. (författare)
  • Deuterium density profile determination at JET using a neutron camera and a neutronspectrometer
  • 2014
  • Ingår i: Review of Scientific Instruments. - 0034-6748 .- 1089-7623. ; 85:11, s. 11E106-
  • Tidskriftsartikel (refereegranskat)abstract
    • In this work we estimate the fuel ion density profile in deuterium plasmas at JET, using the JET neutron camera, the neutron time-of-flight spectrometer TOFOR, and fusion reactivities modeled by the transport code TRANSP. The framework has been tested using synthetic data, which showed that the density profile could be reconstructed with an average accuracy of the order of 10 %. The method has also been applied to neutron measurements from a neutral beam heated JET discharge, which gave nd/ne ≈ 0.6 ± 0.3 in the plasma core and nd/ne ≈ 0.4 ± 0.3 towards the edge. Correction factors for detector efficiencies, neutron attenuation, and back-scattering are not yet included in the analysis; future work will aim at refining the estimated density.
  • Gatu Johnson, Maria, 1978-, et al. (författare)
  • The TOFOR neutron spectrometer and its first use at JET
  • 2006
  • Ingår i: Review of Scientific Instruments. - American Institute of Physics. - 0034-6748 .- 1089-7623. ; 77:10E702, s. 1-3, s. 840-
  • Tidskriftsartikel (refereegranskat)abstract
    • A time-of-flight neutron spectrometer (TOFOR) has been developed to measure the 2.45  MeV  d+d3He+n neutron emission from D plasmas. The TOFOR design features the capability to operate at high rates in the 100  kHz range, data collection with fast time digitizing and storing, and monitoring of the signals from the scintillation detectors used. This article describes the principles of the instrument and its installation at JET and presents preliminary data to illustrate the TOFOR performance as a neutron emission spectroscopy diagnostic.
  • Giacomelli, Luca, et al. (författare)
  • Advanced Neutron Diagnostics for JET and ITER Fusion Experiments
  • 2005
  • Ingår i: Nuclear Fusion. ; 45, s. 1191-1201
  • Tidskriftsartikel (refereegranskat)abstract
    • The diagnostics functions of neutron measurements as well as the roles played by neutron yield monitors, cameras and spectrometers are reviewed. The importance of recent developments in neutron emission spectroscopy (NES) diagnostics is emphasized. Results are presented from the NES diagnosis of the Joint European Torus (JET) plasmas performed with the magnetic proton recoil (MPR) spectrometer during the first deuterium tritium experiment of 1997 and the recent trace tritium experiment of 2003. The NES diagnostic capabilities at JET are presently being enhanced by an upgrade of the MPR (MPRu) and a new 2.5 MeV time-of-flight (TOF) neutron spectrometer (TOFOR). The principles of MPRu and TOFOR are described and illustrated with the diagnostic role they will play in the high performance fusion experiments in the forward programme of JET largely aimed at supporting the International Thermonuclear Experimental Reactor (ITER). The importance of the JET NES effort for ITER is discussed.
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