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Sökning: WFRF:(Giannuzzi P)

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  • Piepoli, MF, et al. (författare)
  • Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)
  • 2004
  • Ingår i: BMJ: British Medical Journal. - : BMJ Publishing Group. - 1756-1833. ; 328:7433, s. 189-192
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective To determine the effect of exercise training on survival in patients with heart failure due to left ventricular systolic dysfunction. Design Collaborative meta-analysis. Inclusion criteria Randomised parallel group controlled trials of exercise training, for at least eight weeks with individual patient data on survival for at least three months. Studies reviewed Nine datasets, totalling 801 patients: 395 received exercise training and 406 were controls. Main outcome measure Death from all causes. Results During a mean (SD) follow up of 705 (729) days there were 88 (22%) deaths in the exercise arm and 105 (26%) in the control arm. Exercise training significantly reduced mortality (hazard ratio 0.65, 95% confidence interval, 0.46 to 0.92; log rank chi(2) = 5.9; P = 0.015). The secondary end point of death or admission to hospital was also reduced (0.72, 0.56 to 0.93; log rank chi(2) = 6.4; P = 0.011). No statistically significant subgroup specific treatment effect was observed. Conclusion Meta-analysis of randomised trials to date gives no evidence that properly supervised medical training programmes for patients with heart failure might be dangerous, and indeed there is clear evidence of an overall reduction in mortality. Further research should focus on optimising exercise programmes and identifying appropriate patient groups to target.
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  • Piepoli, Massimo F, et al. (författare)
  • Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation
  • 2011
  • Ingår i: EUROPEAN JOURNAL OF HEART FAILURE. - : Oxford University Press. - 1388-9842. ; 13:4, s. 347-357
  • Tidskriftsartikel (refereegranskat)abstract
    • The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside specialized centres and in the real world of heart failure clinics. In reality, exercise intolerance can be successfully tackled by applying ET. We need to encourage the mindset that breathlessness may be evidence of signalling between the periphery and central haemodynamic performance and regular physical activity may ultimately bring about favourable changes in myocardial function, symptoms, functional capacity, and increased hospitalization-free life span and probably survival. In this position paper, we provide practical advice for the application of exercise in heart failure and how to overcome traditional barriers, based on the current scientific and clinical knowledge supporting the beneficial effect of this intervention.
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  • Avoni, G., et al. (författare)
  • The new LUCID-2 detector for luminosity measurement and monitoring in ATLAS
  • 2018
  • Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 13:7
  • Tidskriftsartikel (refereegranskat)abstract
    • The ATLAS luminosity monitor, LUCID (LUminosity Cherenkov Integrating Detector), had to be upgraded for the second run of the LHC accelerator that started in spring 2015. The increased energy of the proton beams and the higher luminosity required a redesign of LUCID to cope with the more demanding conditions. The novelty of the LUCID-2 detector is that it uses the thin quartz windows of photomultipliers as Cherenkov medium and a small amounts of radioactive 207Bi sources deposited on to these windows to monitor the gain stability of the photomultipliers. The result is a fast and accurate luminosity determination that can be kept stable during many months of data taking. LUCID-2 can also measure the luminosity accurately online for each of the up to 2808 colliding bunch pairs in the LHC . These bunch pairs are separated by only 25 ns and new electronics has been built that can count not only the number of pulses above threshold but also integrate the pulses.
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