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Sökning: WFRF:(Gislason Thorarinn) > Linköpings universitet

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1.
  • Arnardottir, Erna S I F, et al. (författare)
  • Sleep-related sweating in obstructive sleep apnoea: association with sleep stages and blood pressure
  • 2010
  • Ingår i: JOURNAL OF SLEEP RESEARCH. - : Wiley. - 0962-1105 .- 1365-2869. ; 19:1, s. 122-130
  • Tidskriftsartikel (refereegranskat)abstract
    • Pandgt;The aim of this study was to investigate sleep-related sweating as a symptom of obstructive sleep apnoea (OSA). Fifteen otherwise healthy male non-smoking patients with untreated moderate-to-severe OSA underwent polysomnography, including measurements of skin and core body temperature and electrodermal activity (EDA) as an objective indicator of sweating. Evening and morning blood pressure was measured as well as catecholamines in nocturnal urine. All measurements were repeated after 3 months on successful continuous positive airway pressure (CPAP) treatment. The untreated OSA subjects had a mean (+/- SD) apnoea-hypopnoea index of 45.3 +/- 3.9 and a mean EDA index during sleep of 131.9 +/- 22.4 events per hour. Patients with higher EDA indices had higher systolic blood pressure in the evening and morning (P = 0.001 and 0.006) and lower rapid eye movement (REM) sleep percentage (P = 0.003). The EDA index decreased significantly to 78.5 +/- 17.7 in the patients on CPAP treatment (P = 0.04). The decrease correlated with lower evening systolic and diastolic blood pressure (P = 0.05 and 0.006) and an increase in REM% (P = 0.02). No relationship was observed between EDA and skin or core body temperature, or to catecholamine levels in urine. OSA patients who experience sleep-related sweating may have increased blood pressure and decreased REM sleep compared with other OSA patients. CPAP treatment appears to lower blood pressure and increase REM sleep to a higher extent in these patients compared with other OSA patients.
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2.
  • Gislason, Thorarinn, et al. (författare)
  • Obstructive sleep apnoea in adults
  • 2014. - 65
  • Ingår i: Respiratory epidemiology. - : European Respiratory Society. - 9781849840521 ; , s. 88-105
  • Bokkapitel (refereegranskat)abstract
    • Over the past 30 years OSA has evolved from being a very rare disorder, almost solely characterised by loud snoring and daytime sleepiness, to a common systemic disorder with multiple adverse consequences, which affect a substantial percentage of the middle-aged population. Obesity is the strongest risk factor, but not the only pathogenic mechanism. Other important mechanisms include differences in craniofacial dimensions and even lifestyle factors such as smoking, alcohol consumption and sleeping position. Given the systemic effects, there is developing evidence for the role of OSA as an independent risk factor for: excessive sleepiness with increased risk of traffic accidents, hypertension, cardiovascular disease (including atherosclerosis), myocardial infarction, stroke, impaired glucose metabolism, neurodegeneration, and both cancer mortality and incident cancer. Subjects with untreated OSA have increased mortality and are at higher risk when undergoing surgical procedures. The major clinical challenge today is how simplified diagnostic procedures can confirm or reject the possibility of OSA in various situations. 
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refereegranskat (2)
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Gislason, Thorarinn (2)
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Arnardottir, Erna S ... (1)
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Linköpings universitet  (2)Ta bort avgränsningen
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