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- Goon, Anthony, et al.
(författare)
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Correlation between Stated and Measured Concentrations of Acrylate and Methacrylate Allergens in Patch-Test Preparations
- 2011
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Ingår i: Dermatitis. - : Mary Ann Liebert Inc. - 1710-3568. ; 22:1, s. 27-32
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Tidskriftsartikel (refereegranskat)abstract
- Background: Contact allergy to acrylates and methacrylates is not uncommon. The allergy is confirmed by patch-testing patients with commercial patch-test preparations. Objective: To investigate acrylate and methacrylate allergens used for patch testing in nine different dermatology departments from Europe, America, Asia, and Australia. Methods: The acrylate and methacrylate (methyl methacrylate, 2-hydroxypropyl acrylate, 2-hydroxyethyl methacrylate, ethylene glycol dimethacrylate, and triethylene glycol diacrylate) allergen samples were analyzed with high-performance liquid chromatography to measure the allergen content. Results: Variation in measured versus stated concentrations was seen in these samples. The ratio of measured to stated concentrations ranged from 0.11 to 1.1. Only 22 (63%) of 35 samples were within the arbitrary acceptable limits of 80 to 120% of the stated concentrations. Conclusion: The results may have implications for individual diagnosis and prevention and when test results from various centers are compared.
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| 2. |
- Goon, Anthony Teik-Jin, et al.
(författare)
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Screening for acrylate/methacrylate allergy in the baseline series: our experience in Sweden and Singapore
- 2008
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873. ; 59:5, s. 307-313
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Tidskriftsartikel (refereegranskat)abstract
- Background: No studies to specifically determine the prevalence of contact allergy to acrylates/methacrylates in patch tested populations have been published. Objectives: To determine the prevalence of acrylate/methacrylate allergy in all patients tested to the baseline patch test series. Methods: Five acrylate/methacrylate allergens (2-hydroxyethyl methacrylate, methyl methacrylate, ethylene glycol dimethacrylate, triethylene glycol diacrylate, and 2-hydroxypropyl acrylate) were included in the baseline series for at least 2 years in Malmo and Singapore. Results: Thirty-eight patients in total had reacted to acrylate/methacrylate allergens in the baseline series during the study period in both populations. In Malmo, there were 26 (1.4%) patients with positive patch tests to acrylate/methacrylate allergens, 14 of whom had relevant reactions. In Singapore, there were 12 (1.0%) patients with positive patch tests to acrylate/methacrylate allergens, but only 1 had relevant reactions. If we had not added acrylate/methacrylate allergens to the baseline series, we would not have patch tested 13/26 (50%) of the positive reactors in Malmo and 11/12 (92%) of the positive reactors in Singapore. The overall proportion of missed positive reactors would have been 24/38 (63%). Conclusions: The prevalence of acrylate/methacrylate allergy in our patch tested dermatitis populations is 1.4% in Malmo and 1.0% in Singapore.
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