| 1. |
- Kminek, G, et al.
(författare)
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COSPAR Sample Safety Assessment Framework (SSAF)
- 2022
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Ingår i: Astrobiology. - : Mary Ann Liebert Inc.. - 1531-1074 .- 1557-8070. ; 22:S1, s. S186-S216
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Tidskriftsartikel (refereegranskat)abstract
- The Committee on Space Research (COSPAR) Sample Safety Assessment Framework (SSAF) has been developed by a COSPAR appointed Working Group. The objective of the sample safety assessment would be to evaluate whether samples returned from Mars could be harmful for Earth's systems (e.g., environment, biosphere, geochemical cycles). During the Working Group's deliberations, it became clear that a comprehensive assessment to predict the effects of introducing life in new environments or ecologies is difficult and practically impossible, even for terrestrial life and certainly more so for unknown extraterrestrial life. To manage expectations, the scope of the SSAF was adjusted to evaluate only whether the presence of martian life can be excluded in samples returned from Mars. If the presence of martian life cannot be excluded, a Hold & Critical Review must be established to evaluate the risk management measures and decide on the next steps. The SSAF starts from a positive hypothesis (there is martian life in the samples), which is complementary to the null-hypothesis (there is no martian life in the samples) typically used for science. Testing the positive hypothesis includes four elements: (1) Bayesian statistics, (2) subsampling strategy, (3) test sequence, and (4) decision criteria. The test sequence capability covers self-replicating and non-self-replicating biology and biologically active molecules. Most of the investigations associated with the SSAF would need to be carried out within biological containment. The SSAF is described in sufficient detail to support planning activities for a Sample Receiving Facility (SRF) and for preparing science announcements, while at the same time acknowledging that further work is required before a detailed Sample Safety Assessment Protocol (SSAP) can be developed. The three major open issues to be addressed to optimize and implement the SSAF are (1) setting a value for the level of assurance to effectively exclude the presence of martian life in the samples, (2) carrying out an analogue test program, and (3) acquiring relevant contamination knowledge from all Mars Sample Return (MSR) flight and ground elements. Although the SSAF was developed specifically for assessing samples from Mars in the context of the currently planned NASA-ESA MSR Campaign, this framework and the basic safety approach are applicable to any other Mars sample return mission concept, with minor adjustments in the execution part related to the specific nature of the samples to be returned. The SSAF is also considered a sound basis for other COSPAR Planetary Protection Category V, restricted Earth return missions beyond Mars. It is anticipated that the SSAF will be subject to future review by the various MSR stakeholders. © Gerhard Kminek et al., 2022;
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| 2. |
- Bennion, Douglas M, et al.
(författare)
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Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke : a nose-to-brain delivery approach.
- 2018
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Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 132:5, s. 581-593
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Tidskriftsartikel (refereegranskat)abstract
- Significant neuroprotective effects of angiotensin II type 2 (AT2) receptor (AT2 receptor) agonists in ischemic stroke have been previously demonstrated in multiple studies. However, the routes of agonist application used in these pre-clinical studies, direct intracerebroventricular (ICV) and systemic administration, are unsuitable for translation into humans; in the latter case because AT2 receptor agonists are blood-brain barrier (BBB) impermeable. To circumvent this problem, in the current study we utilized the nose-to-brain (N2B) route of administration to bypass the BBB and deliver the selective AT2 receptor agonist Compound 21 (C21) to naïve rats or rats that had undergone endothelin 1 (ET-1)-induced ischemic stroke. The results obtained from the present study indicated that C21 applied N2B entered the cerebral cortex and striatum within 30 min in amounts that are therapeutically relevant (8.4-9 nM), regardless of whether BBB was intact or disintegrated. C21 was first applied N2B at 1.5 h after stroke indeed provided neuroprotection, as evidenced by a highly significant, 57% reduction in cerebral infarct size and significant improvements in Bederson and Garcia neurological scores. N2B-administered C21 did not affect blood pressure or heart rate. Thus, these data provide proof-of-principle for the idea that N2B application of an AT2 receptor agonist can exert neuroprotective actions when administered following ischemic stroke. Since N2B delivery of other agents has been shown to be effective in certain human central nervous system diseases, the N2B application of AT2 receptor agonists may become a viable mode of delivering these neuroprotective agents for human ischemic stroke patients
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| 3. |
- Nguyen, Sang N., et al.
(författare)
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Methodology for predicting the threat of runway debris impact to large transport aircraft
- 2012
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Konferensbidrag (refereegranskat)abstract
- Large transport aircraft are particularly susceptible to impact damage from runway debris thrown up by the landing gear. A methodology was developed to predict the trajectories of stones lofted by the nose wheel and subjected to aerodynamics forces due to the wake behind the nose landing gear and beneath the aircraft. In conjunction with finite element modeling of the stone/ground/tire contact mechanics, a Matlab model was used to perform a stochastic prediction of the trajectories of runway stones to generate impact threat maps which showed the relative likelihood of stones impinging upon various areas on the underside of a C-130 Hercules. The impact envelopes for the C-130 extended 2.4 to 17.5 meters behind the nose wheel and two meters either side of the center of the aircraft. The impact threat maps were especially sensitive to the values of the coefficients of lift and drag acting on the stone during its flight.
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| 4. |
- Nguyen, Sang N., et al.
(författare)
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Runway debris impact threat maps for transport aircraft
- 2014
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Ingår i: Aeronautical Journal. - 0001-9240. ; 118:1201, s. 229-266
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Tidskriftsartikel (refereegranskat)abstract
- Large transport aircraft are particularly susceptible to impact damage from runway debris thrown up by the landing gear. A methodology was developed to predict the trajectories of stones lofted by the nose wheel and subjected to aerodynamic forces due to the wake behind the nose landing gear and beneath the aircraft. In conjunction with finite element modelling of the stone/ground/tyre contact mechanics, an analytical model was used to perform a stochastic prediction of the trajectories of runway stones to generate impact threat maps which showed the relative likelihood of stones impinging upon various areas on the underside of a C-130 Hercules. The impact envelopes for the C-130 extended three to eighteen metres behind the nose wheel and two metres either side of the centre of the aircraft. The impact threat maps were especially sensitive to the values of the coefficients of lift and drag acting on the stone during its flight.
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