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- Cronin, Simon, et al.
(författare)
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Screening of hypoxia-inducible genes in sporadic ALS
- 2008
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Ingår i: Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders. - : Informa Plc. - 1466-0822 .- 1743-4483. ; 9:5, s. 299-305
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Tidskriftsartikel (refereegranskat)abstract
- Genetic variations in two hypoxia-inducible angiogenic genes, VEGF and ANG, have been linked with sporadic amyotrophic lateral sclerosis (SALS). Common variations in these genes may reduce the levels or functioning of their products. VEGF and ANG belong to a larger group of angiogenic genes that are up-regulated under hypoxic conditions. We hypothesized that common genetic variation across other members of this group may also predispose to sporadic ALS. To screen other hypoxia-inducible angiogenic genes for association with SALS, we selected 112 tagging single nucleotide polymorphisms (tgSNPs) that captured the common genetic variation across 16 VEGF-like and eight ANG-like hypoxia-inducible genes. Screening for association was performed in 270 Irish individuals with typical SALS and 272 ethnically matched unrelated controls. SNPs showing association in the Irish phase were genotyped in a replication sample of 281 Swedish sporadic ALS patients and 286 Swedish controls. Seven markers showed association in the Irish. The one modest replication signal observed in the Swedish replication sample, at rs3801158 in the gene inhibin beta A, was for the opposite allele vs. the Irish cohort. We failed to detect association of common variation across 24 candidate hypoxia-inducible angiogenic genes with SALS.
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- Moosmann, Marvin, et al.
(författare)
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On the evolution of trophic position
- 2021
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 24:12, s. 2549-2562
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Tidskriftsartikel (refereegranskat)abstract
- The trophic structure of food webs is primarily determined by the variation in trophic position among species and individuals. Temporal dynamics of food web structure are central to our understanding of energy and nutrient fluxes in changing environments, but little is known about how evolutionary processes shape trophic position variation in natural populations. We propose that trophic position, whose expression depends on both environmental and genetic determinants of the diet variation in individual consumers, is a quantitative trait that can evolve via natural selection. Such evolution can occur either when trophic position is correlated with other heritable morphological and behavioural traits under selection, or when trophic position is a target of selection, which is possible if the fitness effects of prey items are heterogeneously distributed along food chains. Recognising trophic position as an evolving trait, whose expression depends on the food web context, provides an important conceptual link between behavioural foraging theory and food web dynamics, and a useful starting point for the integration of ecological and evolutionary studies of trophic position.
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- Vymazal, J, et al.
(författare)
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Constructed wetlands for wastewater treatment
- 2006
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Ingår i: Wetlands and Natural Resource Management. Ecological Studies. - Berlin : Springer Verlag. - 3540331867 ; , s. 69-96
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Together with its companion, Volume 191 Wetlands: Functioning, Biodiversity Conservation and Restoration, this book provides a broad and well-integrated overview of recent major scientific results in wetland science and their applications in natural resource management issues.After an introduction to the field, a group of internationally known experts summarizes the state of the art on an array of topics, divided into four sections:-The Role of Wetlands for Integrated Water Resources Management: Putting Theory into Practice-Wetland Science for Environmental Management-Wetland Biogeochemistry-Wetlands and Climate Change Worldwide The volume will be useful to wetland scientists and natural resource managers, as well as environmental policy makers at all levels.
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