| 1. |
- Wang, Fang, et al.
(author)
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Emerging contaminants: A One Health perspective
- 2024
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In: Innovation. - 2666-6758. ; 5
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Research review (peer-reviewed)abstract
- Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN's Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.
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| 2. |
- Gu, X., et al.
(author)
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Impacts of anthropogenic warming and uneven regional socio-economic development on global river flood risk
- 2020
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In: Journal of Hydrology. - : Elsevier BV. - 0022-1694. ; 590
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Journal article (peer-reviewed)abstract
- Employing a multi-model framework, we estimate the impacts of contrasting warming levels and uneven regional socio-economic development on area, population and gross domestic product (GDP) exposures to flood magnitude and variability in global Flood-Affected Regions (FARs). These exposures to flood variability show persistent increases in FARs, but to flood magnitude only in East and South Asia. Globally, the increases in these exposures are not projected in moderate but extreme floods. Specifically, the areal exposure would be decreased (increased) by 1.8%/°C (1.9%/°C) for moderate (extreme) floods; the reduced population exposure to extreme floods can be three times higher than that to moderate floods when limiting 2 °C to 1.5 °C warming. Rapid regional economic growth of East and South Asia (whose GDP accounts for 9.8% of FARs in year 2000 to 18.5% in year 2025) would shift global GDP exposure from a decrease of 2.5%/°C to an increase of 1.7%/°C. © 2020 Elsevier B.V.
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| 3. |
- Krueger, Jacob, et al.
(author)
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Where is my feature and what is it about? A case study on recovering feature facets
- 2019
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In: Journal of Systems and Software. - : Elsevier BV. - 0164-1212. ; 152, s. 239-253
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Journal article (peer-reviewed)abstract
- Developers commonly use features to define, manage, and communicate functionalities of a system. Unfortunately, the locations of features in code and other characteristics (feature facets), relevant for evolution and maintenance, are often poorly documented. Since developers change, and knowledge fades with time, such information often needs to be recovered. Modern projects boast a richness of information sources, such as pull requests, release logs, and otherwise specified domain knowledge. However, it is largely unknown from what sources the features, their locations, and their facets can be recovered. We present an exploratory study on identifying such information in two popular, variant-rich, and long-living systems: The 3D-printer firmware Marlin and the Android application Bitcoin-wallet. Besides the available information sources, we also investigated the projects' communities, communications, and development cultures. Our results show that a multitude of information sources (e.g., commit messages and pull requests) is helpful to recover features, locations, and facets to different extents. Pull requests were the most valuable source to recover facets, followed by commit messages and the issue tracker. As many of the studied information sources are, so far, rarely exploited in techniques for recovering features and their facets, we hope to inspire researchers and tool builders with our results. (C) 2019 Elsevier Inc. All rights reserved.
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| 4. |
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| 5. |
- Li, Siqi, et al.
(author)
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The Chinese Mandarin Version of the Esophageal-Atresia-Quality-of-Life Questionnaires for Children and Adolescents: Evaluation of Linguistic and Content Validity.
- 2022
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In: International journal of environmental research and public health. - : MDPI AG. - 1660-4601. ; 19:22
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Journal article (peer-reviewed)abstract
- After repair of esophageal atresia (EA), children risk digestive and respiratory morbidity, but knowledge of their health-related quality of life (HRQOL) in China is lacking. The EA-QOL questionnaires were developed in Sweden and Germany to evaluate condition-specific HRQOL in children with EA aged 2-7 and 8-17. This study aimed to evaluate the linguistic and content validity of the Chinese Mandarin version of the EA-QOL questionnaires.The procedure was conducted in compliance with international standards, including a forward-backward translation procedure, expert reviews, and cognitive debriefing interviews with 14 Chinese families of children with EA (parents of 8 children aged 2-7/6 children aged 8-17 and their parents).Following forward-backward translation, minor issues were identified and solved. In interviews, all participants rated all EA-QOL items easy to understand, none expressed negative emotions about them and most described them comprehensive and relevant for EA. Leading from cognitive debriefing, three EA-QOL items in the questionnaire version for children aged 2-7 and three EA-QOL items in the questionnaire version for children aged 8-17 were modified in the Chinese language to improve cultural appropriateness and/or clarity.The Chinese Mandarin version of the EA-QOL questionnaires achieved satisfactory linguistic and content validity. This can help increase focus of HRQOL in research and clinical practice of children with EA in China.
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| 6. |
- Wu, Xifeng, et al.
(author)
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Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
- 2009
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In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:9, s. 991-5
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Journal article (peer-reviewed)abstract
- We conducted a genome-wide association study on 969 bladder cancer cases and 957 controls from Texas. For fast-track validation, we evaluated 60 SNPs in three additional US populations and validated the top SNP in nine European populations. A missense variant (rs2294008) in the PSCA gene showed consistent association with bladder cancer in US and European populations. Combining all subjects (6,667 cases, 39,590 controls), the overall P-value was 2.14 x 10(-10) and the allelic odds ratio was 1.15 (95% confidence interval 1.10-1.20). rs2294008 alters the start codon and is predicted to cause truncation of nine amino acids from the N-terminal signal sequence of the primary PSCA translation product. In vitro reporter gene assay showed that the variant allele significantly reduced promoter activity. Resequencing of the PSCA genomic region showed that rs2294008 is the only common missense SNP in PSCA. Our data identify rs2294008 as a new bladder cancer susceptibility locus.
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| 7. |
- Yao, Tandong, et al.
(author)
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Recent Third Pole’s rapid warming accompanies cryospheric melt and water cycle intensification and interactions between monsoon and environment: multi-disciplinary approach with observation, modeling and analysis
- 2019
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In: Bulletin of The American Meteorological Society. - 0003-0007 .- 1520-0477. ; :March, s. 423-444
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Journal article (peer-reviewed)abstract
- The Third Pole (TP) is experiencing rapid warming and is currently in its warmest period in the past 2,000 years. This paper reviews the latest development in multidisciplinary TP research associated with this warming. The rapid warming facilitates intense and broad glacier melt over most of the TP, although some glaciers in the northwest are advancing. By heating the atmosphere and reducing snow/ice albedo, aerosols also contribute to the glaciers melting. Glacier melt is accompanied by lake expansion and intensification of the water cycle over the TP. Precipitation has increased over the eastern and northwestern TP. Meanwhile, the TP is greening and most regions are experiencing advancing phenological trends, although over the southwest there is a spring phenological delay mainly in response to the recent decline in spring precipitation. Atmospheric and terrestrial thermal and dynamical processes over the TP affect the Asian monsoon at different scales. Recent evidence indicates substantial roles that mesoscale convective systems play in the TP’s precipitation as well as an association between soil moisture anomalies in the TP and the Indian monsoon. Moreover, an increase in geohazard events has been associated with recent environmental changes, some of which have had catastrophic consequences caused by glacial lake outbursts and landslides. Active debris flows are growing in both frequency of occurrences and spatial scale. Meanwhile, new types of disasters, such as the twin ice avalanches in Ali in 2016, are now appearing in the region. Adaptation and mitigation measures should be taken to help societies’ preparation for future environmental challenges. Some key issues for future TP studies are also discussed.
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