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- Jean, J. -S, et al.
(författare)
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The Taiwan crisis : A showcase of the global arsenic problem
- 2010
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- In the 1950s, the residents of the southwestern coastal areas of Taiwan suffered greatly from Blackfoot disease (BFD) due to the consumption of arsenic-contaminated groundwater. Groundwater with high levels of arsenic in southwestern and northeastern Taiwan received much attention. After arsenic-safe tap water was utilized for drinking instead of groundwater in the 1970s, BFD cases decreased greatly. After 1990, no new BFD cases were reported, and as a consequence, BFD problems disregarded. However, arsenic is still present in the groundwater.This book will improve the knowledge and understanding of the occurrence and genesis of arsenic-rich groundwaters in Taiwan. It deals with constraints on the mobility of arsenic in groundwater, its uptake from soil and water by plants, arsenic-propagation through the food chain, human health impacts, and arsenic-removal technologies. Taiwan case experiences are described in this book and can be applied worldwide. This book is a state-of-the-art overview of research on arsenic in Taiwan and is designed to: • create interest in regions within Taiwan that are affected by the presence of arseniferous aquifers; • draw attention from the international scientific community; • increase awareness among researchers, administrators, policy makers, and company executives; • improve the international cooperation on arsenic problems worldwide.
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- Kelsoe, John, et al.
(författare)
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Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
- 2023
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Ingår i: Research square.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
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- Chen, Guo, 1969, et al.
(författare)
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Glassy Dynamics of Proteins
- 2012
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Ingår i: Structural Glasses and Supercooled Liquids: Theory, Experiment, and Applications. - : Wiley. - 9780470452233 ; , s. 319-339
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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