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Träfflista för sökning "WFRF:(Guo Xin) ;hsvcat:1;lar1:(ki)"

Search: WFRF:(Guo Xin) > Natural sciences > Karolinska Institutet

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1.
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2.
  • 2019
  • Journal article (peer-reviewed)
  •  
3.
  • Wang, Jijing, et al. (author)
  • Testing the link between isoaspartate and Alzheimer's disease etiology
  • 2023
  • In: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279. ; 19:4, s. 1491-1502
  • Journal article (peer-reviewed)abstract
    • Isoaspartate (isoAsp) is a damaging amino acid residue formed in proteins as a result of spontaneous deamidation. IsoAsp disrupts protein structures, making them prone to aggregation. Here we strengthened the link between isoAsp and Alzheimer's disease (AD) by novel approaches to isoAsp analysis in human serum albumin (HSA), the most abundant blood protein and a major carrier of amyloid beta (A beta) and phosphorylated tau (p-tau) in blood. We discovered a reduced amount of anti-isoAsp antibodies (P < 0.0001), an elevated isoAsp level in HSA (P < 0.001), more HSA aggregates (P < 0.0001), and increased levels of free A beta (P < 0.01) in AD blood compared to controls. We also found that deamidation significantly reduces HSA capacity to bind with A beta and p-tau (P < 0.05). These suggest the presence in AD of a bottleneck in clearance of A beta and p-tau, leading to their increased concentrations in the brain and facilitating their aggregations there.
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4.
  • Zhang, Jiming, et al. (author)
  • Maternal urinary carbofuranphenol levels before delivery and birth outcomes in Sheyang Birth Cohort
  • 2018
  • In: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 625, s. 1667-1672
  • Journal article (peer-reviewed)abstract
    • Exposure to carbamates has been linked with adverse health effects on developmental period. This study aimed to monitor exposure to carbofuranphenol of pregnant women from Sheyang Birth Cohort and investigate associations between prenatal exposure to carbofuranphenol and birth outcomes. During June 2009 to January 2010, 1100 pregnant women living in Sheyang County participated in our study and donated urine sample. Urinary carbofuranphenol concentration was measured by gas chromatography-tandem mass spectrometry. Associations between urinary carbofuranphenol levels and infant birth outcomes were assessed by generalized linear models. Urinary carbofuranphenol concentrations varied from 0.01 to 395.40μg/L (0.01-303.93μg/g for creatinine adjusted), the geometric mean, median and inter quartile range are 0.81μg/L (1.28μg/g cr), 0.80μg/L (1.23μg/g cr) and 0.27-2.20μg/L (0.47-3.11μg/g cr), respectively. No statistically significant association between maternal urinary carbofuranphenol levels and birth outcomes was found in total infants and female infants. In male neonates, carbofuranphenol level was significantly associated with head circumference (b=-0.226; 95% confidence interval: -0.411, -0.041; P=0.01) and ponderal index (b=0.043, 95% CI: 0.004, 0.083; P=0.03). These findings suggested that the pregnant women were generally exposed to carbofuranphenol and prenatal exposure to carbofuranphenol might have adverse effects on fetal development.
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  • Result 1-4 of 4
Type of publication
journal article (4)
Type of content
peer-reviewed (4)
Author/Editor
Zhang, Yan (1)
Korhonen, Laura (1)
Lindholm, Dan (1)
Kelly, Daniel (1)
Vertessy, Beata G. (1)
Bengtsson-Palme, Joh ... (1)
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Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
Wang, Mei (1)
Wang, Xin (1)
Liu, Yang (1)
Kumar, Rakesh (1)
Wang, Dong (1)
Liu, Fang (1)
Li, Ke (1)
Liu, Ke (1)
Zhang, Yang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Nàgy, Péter (1)
Kahan, Thomas (1)
Kominami, Eiki (1)
van der Goot, F. Gis ... (1)
Sörelius, Karl, 1981 ... (1)
Bonaldo, Paolo (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Adams, Christopher M (1)
Zubarev, Roman A (1)
Minucci, Saverio (1)
Vellenga, Edo (1)
Backman, Lars (1)
Yan, Hong (1)
Swärd, Karl (1)
Nilsson, Per (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
De Milito, Angelo (1)
Zhang, Wei (1)
Zhang, Jian (1)
Hammerschmidt, Sven (1)
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Shukla, Deepak (1)
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University
Karolinska Institutet  (4)Undo refine
Uppsala University (2)
Stockholm University (2)
Lund University (2)
University of Gothenburg (1)
Umeå University (1)
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Halmstad University (1)
Örebro University (1)
Linköping University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
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Language
English (4)
Research subject (UKÄ/SCB)
Natural sciences (4)Undo refine
Medical and Health Sciences (4)

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