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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Abgrall, N., et al.
(författare)
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The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
- 2017
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Ingår i: AIP Conference Proceedings. - : Author(s). - 1551-7616 .- 0094-243X. ; 1894
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Konferensbidrag (refereegranskat)abstract
- The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results.
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| 4. |
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| 5. |
- López-Puertas, M., et al.
(författare)
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Non-local thermodynamic equilibrium limb radiances for the mipas instrument on Envisat-1
- 1998
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - 0022-4073 .- 1879-1352. ; 59:3-5, s. 377-403
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Tidskriftsartikel (refereegranskat)abstract
- An evaluation of the effects that the assumption of local thermodynamic equilibrium (LTE) has on the retrieval of pressure, temperature and the five primary target gases (O3, H2O, CH4, N2O, and HNO3) from spectra to be taken by Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) on the Envisat-1 platform has been conducted. For doing so, non-LTE and LTE limb radiances in the spectral range of 680–2275 cm−1 (4.15–14.6 μm) with a resolution of 0.05 cm−1 at tangent heights from 10 to 70 km have been computed. These calculations included the most updated non-LTE populations of a large number of vibrational levels of the CO2, O3, H2O, CH4, N2O and HNO3 molecules which cause the most prominent atmospheric infrared emissions. A discussion of the most important non-LTE effects on the limb radiances as well as on the retrievals of pressure-temperature and volume mixing ratios of O3, H2O, CH4, N2O, and HNO3 is presented, together with the most important non-LTE issues that could be studied with the future coming of MIPAS data.
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| 6. |
- Manuilova, R.O., et al.
(författare)
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Modelling of non-LTE limb spectra of i.r. ozone bands for the MIPAS space experiment
- 1998
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Ingår i: Journal of Quantitative Spectroscopy and Radiative Transfer. - 0022-4073 .- 1879-1352. ; 59:3-5, s. 405-422
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Tidskriftsartikel (refereegranskat)abstract
- A new model for calculating the populations of the ozone vibrational states under non-LTE (Local Thermodynamic Equilibrium) conditions is presented. In the model, 23 vibrational levels of the O3 molecule, as well as three vibrational levels of the O2 molecule and two vibrational levels of the N2 molecule, are considered. The radiative transfer at the break-down of LTE was treated explicitly for 150 000 ro-vibrational transitions. The populations obtained were used to calculate limb radiances in various spectral regions of the 4.8 and 9.6 μm bands. Test retrievals of O3 vertical volume mixing ratio (VMR) profiles with a radiance model disregarding non-LTE were performed in order to assess the potential impact of non-LTE effects on the retrieval of the O3 abundances from MIPAS (Michelson Interferometer for Passive Atmospheric Sounding) measurements.
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| 7. |
- Zlotina, A, et al.
(författare)
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A 300-kb microduplication of 7q36.3 in a patient with triphalangeal thumb-polysyndactyly syndrome combined with congenital heart disease and optic disc coloboma: a case report
- 2020
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Ingår i: BMC medical genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 13:1, s. 175-
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundTriphalangeal thumb-polysyndactyly syndrome (TPT-PS) is a rare well-defined autosomal dominant disorder characterized by long thumbs with three phalanges combined with pre- and postaxial polydactyly/syndactyly of limbs. By now, the syndrome has been reported in several large families from different ethnic backgrounds, with a high degree of inter- and intrafamilial variability. The genome locus responsible for TPT-PS has been mapped to the 7q36.3 region harboring a long-range sonic hedgehog (SHH) regulatory sequence (ZRS). Both single-nucleotide variants and complete duplications of ZRS were shown to cause TPT-PS and similar limb phenotypes. TPT-PS usually forms as isolated limb pathology not associated with additional malformations, in particular, with cardiovascular abnormalities.Case presentationHere we report on a rare Russian neonatal case of TPT-PS combined with severe congenital heart disease, namely double outlet right ventricle, and microphthalmia with optic disc coloboma. Pedigree analysis revealed TPT-PS of various expressivity in 10 family members throughout five generations, while the cardiac defect and the eye pathology were detected only in the proband. To extend the knowledge on genotype–phenotype spectrum of TPT-PS, the careful clinical and genomic analysis of the family was performed. High-resolution array-based comparative genomic hybridization (array-CGH) revealed a ~ 300 kb microduplication of 7q36.3 locus (arr[GRCh37] 7q36.3(156385810_156684811) × 3) that co-segregated with TPT-PS in the proband and her mother. The duplication encompassed three genes includingLMBR1, the intron 5 of which is known to harbor ZRS. Based on whole-exome sequencing data, no additional pathogenic mutations or variants of uncertain clinical significance were found in morbid cardiac genes or genes associated with a microphthalmia/anophthalmia/coloboma spectrum of ocular malformations.ConclusionsThe results support the previous data, indicating that complete ZRS duplication underlies TPT-PS, and suggest a broader phenotypic impact of the 7q36.3 microduplication. Potential involvement of the 7q36.3 microduplication in the patient’s cardiac and eye malformations is discussed. However, the contribution of some additional genetic/epigenetic factors to the complex patient`s phenotype cannot be excluded entirely. Further comprehensive functional studies are needed to prove the possible involvement of the 7q36.3 locus in congenital heart disease and eye pathology.
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| 8. |
- Giacoppo, F., et al.
(författare)
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Recent upgrades of the SHIPTRAP setup : On the finish line towards direct mass spectroscopy of superheavy elements
- 2017
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Ingår i: Acta Physica Polonica B. - 0587-4254. ; 48:3, s. 423-429
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Tidskriftsartikel (refereegranskat)abstract
- With the Penning-trap mass spectrometer SHIPTRAP at GSI, Darmstadt, it is possible to investigate exotic nuclei in the region of the heaviest elements. Few years ago, challenging experiments led to the direct measurements of the masses of neutron-deficient isotopes with Z = 102; 103 around N = 152. Thanks to recent advances in cooling and ion-manipulation techniques, a major technical upgrade of the setup has been recently accomplished to boost its efficiency. At present, the gap to reach more rare and shorter-lived species at the limits of the nuclear landscape has been narrowed.
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| 10. |
- Kaufmann, M., et al.
(författare)
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Satellite observations of daytime and nighttime ozone in the mesosphere and lower thermosphere
- 2003
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 108:9
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Tidskriftsartikel (refereegranskat)abstract
- The global distribution of mesospheric and lower thermospheric ozone 9.6 μm infrared emissions was measured by the Cryogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA) experiment during two Space Shuttle missions in November 1994 and August 1997. The radiances measured by CRISTA have been inverted to O3 number densities in the 50-95 km range by using a nonlocal thermodynamic equilibrium model. A detailed sensitivity study of retrieved O3 number densities has been carried out. The ozone abundance profiles show volume mixing ratios of 1-2 ppmv at the stratopause, 0.5 ppmv or less around 80 km, and typically 1 ppmv during daytime and 10 ppmv during nighttime at the secondary maximum. The agreement with other experiments is typically better than 25%. The global distribution of upper mesospheric ozone shows significant latitudinal gradients and an enhancement in the equatorial upper mesosphere. At the polar night terminator a third ozone maximum is observed. Three-dimensional model results indicate that the latitudinal gradients are significantly influenced by solar tides.
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