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Growth-limiting rol...
Growth-limiting role of endothelial cells in endoderm development
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- Wolfhagen Sand, Fredrik (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Hörnblad, Andreas (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Johansson, Jenny (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Lorén, Christina (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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Edsbagge, Josefina (author)
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Ståhlberg, Anders (author)
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Magenheim, Judith (author)
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Ilovich, Ohad (author)
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Mishani, Eyal (author)
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Dor, Yuval (author)
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- Ahlgren, Ulf (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Semb, Henrik (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- Academic Press, 2011
- 2011
- English.
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In: Developmental Biology. - : Academic Press. - 0012-1606 .- 1095-564X. ; 352:2, s. 267-277
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Abstract
Subject headings
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- Endoderm development is dependent on inductive signals from different structures in close vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we demonstrated that a functional vascular system is necessary for proper pancreas development, and that sphingosine-1-phosphate (S1P) exhibits the traits of a blood vessel-derived molecule involved in early pancreas morphogenesis. To examine whether S1P(1)-signaling plays a more general role in endoderm development, S1P(1)-deficient mice were analyzed. S1P(1) ablation results in compromised growth of several foregut-derived organs, including the stomach, dorsal and ventral pancreas and liver. Within the developing pancreas the reduction in organ size was due to deficient proliferation of Pdx1(+) pancreatic progenitors, whereas endocrine cell differentiation was unaffected. Ablation of endothelial cells in vitro did not mimic the S1P(1) phenotype, instead, increased organ size and hyperbranching were observed. Consistent with a negative role for endothelial cells in endoderm organ expansion, excessive vasculature was discovered in S1P(1)-deficient embryos. Altogether, our results show that endothelial cell hyperplasia negatively influences organ development in several foregut-derived organs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Cell Size
- Computational Biology
- Female
- Image
- Enhancement
- Imaging
- Three-Dimensional
- Insulin-Secreting Cells
- Islets of Langerhans
- Mice
- Mice
- Inbred C57BL
- Organ Size
- Pancreas
- Pancreas
- Exocrine
- Reproducibility of Results
- Tomography
- Optical
- molecular medicine (medical sciences)
- molekylär medicin (medicinska vetenskaper)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Wolfhagen Sand, ...
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Hörnblad, Andrea ...
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Johansson, Jenny
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Lorén, Christina
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Edsbagge, Josefi ...
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Ståhlberg, Ander ...
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Magenheim, Judit ...
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Ilovich, Ohad
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Mishani, Eyal
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Dor, Yuval
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Ahlgren, Ulf
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Semb, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Developmental Bi ...
- By the university
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Umeå University
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Lund University