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Genome-wide association study identifies new prostate cancer susceptibility loci
- Schumacher, Fredrick R. (author)
- Berndt, Sonja I. (author)
- Siddiq, Afshan (author)
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- Jacobs, Kevin B. (author)
- Wang, Zhaoming (author)
- Lindstrom, Sara (author)
- Stevens, Victoria L. (author)
- Chen, Constance (author)
- Mondul, Alison M. (author)
- Travis, Ruth C. (author)
- Stram, Daniel O. (author)
- Eeles, Rosalind A. (author)
- Easton, Douglas F. (author)
- Giles, Graham (author)
- Hopper, John L. (author)
- Neal, David E. (author)
- Hamdy, Freddie C. (author)
- Donovan, Jenny L. (author)
- Muir, Kenneth (author)
- Al Olama, Ali Amin (author)
- Kote-Jarai, Zsofia (author)
- Guy, Michelle (author)
- Severi, Gianluca (author)
- Isaacs, William B. (author)
- Xu, Jianfeng (author)
- Allen, Naomi E. (author)
- Andriole, Gerald L. (author)
- Barricarte, Aurelio (author)
- Boeing, Heiner (author)
- Bueno-de-Mesquita, H. Bas (author)
- Crawford, E. David (author)
- Diver, W. Ryan (author)
- Gonzalez, Carlos A. (author)
- Gaziano, J. Michael (author)
- Giovannucci, Edward L. (author)
- Le Marchand, Loic (author)
- Ma, Jing (author)
- Sieri, Sabina (author)
- Stampfer, Meir J. (author)
- Tjonneland, Anne (author)
- Vineis, Paolo (author)
- Virtamo, Jarmo (author)
- Vogel, Ulla (author)
- Weinstein, Stephanie J. (author)
- Yeager, Meredith (author)
- Thun, Michael J. (author)
- Kolonel, Laurence N. (author)
- Henderson, Brian E. (author)
- Albanes, Demetrius (author)
- Hayes, Richard B. (author)
- Feigelson, Heather Spencer (author)
- Riboli, Elio (author)
- Hunter, David J. (author)
- Chanock, Stephen J. (author)
- Haiman, Christopher A. (author)
- Kraft, Peter (author)
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- (creator_code:org_t)
- 2011-07-08
- 2011
- English.
- In: Human Molecular Genetics. - London : IRL Press. - 0964-6906 .- 1460-2083. ; 20:19, s. 3867-3875
- Journal article (peer-reviewed)
Abstract
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- Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- Schumacher, Fred ...
- Berndt, Sonja I.
- Siddiq, Afshan
- Jacobs, Kevin B.
- Wang, Zhaoming
- Lindstrom, Sara
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- Stevens, Victori ...
- Chen, Constance
- Mondul, Alison M ...
- Travis, Ruth C.
- Stram, Daniel O.
- Eeles, Rosalind ...
- Easton, Douglas ...
- Giles, Graham
- Hopper, John L.
- Neal, David E.
- Hamdy, Freddie C ...
- Donovan, Jenny L ...
- Muir, Kenneth
- Al Olama, Ali Am ...
- Kote-Jarai, Zsof ...
- Guy, Michelle
- Severi, Gianluca
- Gronberg, Henrik
- Isaacs, William ...
- Karlsson, Robert
- Wiklund, Fredrik
- Xu, Jianfeng
- Allen, Naomi E.
- Andriole, Gerald ...
- Barricarte, Aure ...
- Boeing, Heiner
- Bueno-de-Mesquit ...
- Crawford, E. Dav ...
- Diver, W. Ryan
- Gonzalez, Carlos ...
- Gaziano, J. Mich ...
- Giovannucci, Edw ...
- Johansson, Matti ...
- Le Marchand, Loi ...
- Ma, Jing
- Sieri, Sabina
- Stattin, Pär
- Stampfer, Meir J ...
- Tjonneland, Anne
- Vineis, Paolo
- Virtamo, Jarmo
- Vogel, Ulla
- Weinstein, Steph ...
- Yeager, Meredith
- Thun, Michael J.
- Kolonel, Laurenc ...
- Henderson, Brian ...
- Albanes, Demetri ...
- Hayes, Richard B ...
- Feigelson, Heath ...
- Riboli, Elio
- Hunter, David J.
- Chanock, Stephen ...
- Haiman, Christop ...
- Kraft, Peter
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- Umeå University
- Karolinska Institutet
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