| 1. |
- Kanai, M, et al.
(författare)
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- 2023
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swepub:Mat__t
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| 2. |
- Clark, DW, et al.
(författare)
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Associations of autozygosity with a broad range of human phenotypes
- 2019
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957-
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Tidskriftsartikel (refereegranskat)abstract
- In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
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| 3. |
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| 4. |
- Galili, Nir, et al.
(författare)
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The geologic history of seawater oxygen isotopes from marine iron oxides
- 2019
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Ingår i: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 365:6452, s. 469-473
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Tidskriftsartikel (refereegranskat)abstract
- The oxygen isotope composition (delta O-18) of marine sedimentary rocks has increased by 10 to 15 per mil since Archean time. Interpretation of this trend is hindered by the dual control of temperature and fluid delta O-18 on the rocks' isotopic composition. A new delta O-18 record in marine iron oxides covering the past similar to 2000 million years shows a similar secular rise. Iron oxide precipitation experiments reveal a weakly temperature-dependent iron oxide-water oxygen isotope fractionation, suggesting that increasing seawater d(18)O over time was the primary cause of the long-term rise in delta O-18 values of marine precipitates. The O-18 enrichment may have been driven by an increase in terrestrial sediment cover, a change in the proportion of high-and low-temperature crustal alteration, or a combination of these and other factors.
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| 5. |
- Hen, A., et al.
(författare)
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Structural investigation of Np2Co17 and analogue compounds under pressure
- 2014
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 90:5, s. 054107-
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Tidskriftsartikel (refereegranskat)abstract
- The structural behavior of Np2Co17 is investigated by means of high-pressure diamond-anvil compression measurements and is compared with that of the isostructural compounds Lu2Co17 and Lu2Ni17. The Th2Ni17-type hexagonal crystal structure is preserved with no measurable discontinuous volume collapses up to the highest achieved pressure, p = 43 GPa. For Np2Co17, fits to the Birch-Murnaghan and Vinet equations of state give values of the isothermal bulk modulus and its pressure derivative of B-0 = 286 GPa and B-0' = 3, revealing that this Np compound is a highly incompressible solid with stiffness comparable to that of superhard covalently bonded materials. For the Lu2T17 (T = Co, Ni) compounds, the measured bulk modulus changes from B-0 = 137 GPa for T = Co to B-0 = 257 GPa for T = Ni. The isothermal equation of state for the studied compounds are in excellent agreement with the results of ab initio fully relativistic, full-potential local spin-density functional calculations. Theoretical estimates of the bulk modulus are given also for Np2Ni17, for which B-0 is predicted to assume values intermediate between those measured for Lu2Ni17 and Np2Co17.
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| 6. |
- Schiessl, W, et al.
(författare)
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Magnetic properties of the ZnFe2O4 spinel
- 1996
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Ingår i: PHYSICAL REVIEW B-CONDENSED MATTER. - : AMER INST PHYSICS. ; 53:14, s. 9143-9152
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Using neutron diffraction (ND), muon-spin rotation/relaxation (mu SR), and Fe-57 and Zn-67 Mossbauer spectroscopy (MS) we investigated magnetic properties of the normal spinel ZnFe2O4. Inversion is below limits of detection in samples which were slowly co
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