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> Roddam Andrew W. >
Smoking and risk fo...
Smoking and risk for amyotrophic lateral sclerosis : analysis of the EPIC cohort
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Gallo, Valentina (author)
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Bueno-De-Mesquita, H Bas (author)
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Vermeulen, Roel (author)
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show more...
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- Andersen, Peter M (author)
- Umeå universitet,Neurologi
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Kyrozis, Andreas (author)
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Linseisen, Jakob (author)
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Kaaks, Rudolph (author)
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Allen, Naomi E (author)
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Roddam, Andrew W (author)
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Boshuizen, Hendriek C (author)
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Peeters, Petra H (author)
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Palli, Domenico (author)
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Mattiello, Amalia (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Jiménez-Martín, Juan-Manuel (author)
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Díaz, María José Tormo (author)
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Suarez, Laudina Rodriguez (author)
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Trichopoulou, Antonia (author)
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Agudo, Antonio (author)
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Arriola, Larraitz (author)
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Barricante-Gurrea, Aurelio (author)
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Bingham, Sheila (author)
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Khaw, Kay-Tee (author)
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Lindkvist, Björn (author)
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Overvad, Kim (author)
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Bach, Flemming W (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Bergmann, Manuela M (author)
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Boeing, Heiner (author)
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Clavel-Chapelon, Francoise (author)
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Lund, Eiliv (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Middleton, Lefkos (author)
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Vineis, Paolo (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- New York : J. Wiley & Sons, 2009
- 2009
- English.
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In: Annals of Neurology. - New York : J. Wiley & Sons. - 0364-5134 .- 1531-8249. ; 65:4, s. 378-385
- Related links:
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https://opus.bibliot...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Objective: Cigarette smoking has been reported as "probable" risk factor for Amyotrophic Lateral Sclerosis (ALS), a poorly understood disease in terms of aetiology. The extensive longitudinal data of the European Prospective Investigation into Cancer and Nutrition (EPIC) were used to evaluate age-specific mortality rates from ALS and the role of cigarette smoking on the risk of dying from ALS. Methods: A total of 517,890 healthy subjects were included, resulting in 4,591,325 person-years. ALS cases were ascertained through death certificates. Cox hazard models were built to investigate the role of smoking on the risk of ALS, using packs/years and smoking duration to study dose-response. Results: A total of 118 subjects died from ALS, resulting in a crude mortality rate of 2.69 per 100,000/year. Current smokers at recruitment had an almost two-fold increased risk of dying from ALS compared to never smokers (HR = 1.89, 95% C.I. 1.14-3.14), while former smokers at the time of enrollment had a 50% increased risk (HR = 1.48, 95% C.I. 0.94-2.32). The number of years spent smoking increased the risk of ALS (p for trend = 0.002). Those who smoked more than 33 years had more than a two-fold increased risk of ALS compared with never smokers (HR = 2.16, 95% C.I. 1.33-3.53). Conversely, the number of years since quitting smoking was associated with a decreased risk of ALS compared with continuing smoking. Interpretation: These results strongly support the hypothesis of a role of cigarette smoking in aetiology of ALS. We hypothesize that this could occur through lipid peroxidation via formaldehyde exposure.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Gallo, Valentina
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Bueno-De-Mesquit ...
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Vermeulen, Roel
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Andersen, Peter ...
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Kyrozis, Andreas
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Linseisen, Jakob
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show more...
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Kaaks, Rudolph
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Allen, Naomi E
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Roddam, Andrew W
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Boshuizen, Hendr ...
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Peeters, Petra H
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Palli, Domenico
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Mattiello, Amali ...
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Sieri, Sabina
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Tumino, Rosario
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Jiménez-Martín, ...
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Díaz, María José ...
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Suarez, Laudina ...
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Trichopoulou, An ...
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Agudo, Antonio
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Arriola, Larrait ...
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Barricante-Gurre ...
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Bingham, Sheila
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Khaw, Kay-Tee
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Manjer, Jonas
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Lindkvist, Björn
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Overvad, Kim
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Bach, Flemming W
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Tjønneland, Anne
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Olsen, Anja
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Bergmann, Manuel ...
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Boeing, Heiner
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Clavel-Chapelon, ...
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Lund, Eiliv
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Hallmans, Göran, ...
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Middleton, Lefko ...
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Vineis, Paolo
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Riboli, Elio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Annals of Neurol ...
- By the university
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Umeå University
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Lund University