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Spatially resolved clonal copy number alterations in benign and malignant tissue
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- Erickson, A (author)
- Univ Oxford, Nuffield Dept SurgicalSci, Oxford, England.
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- He, Mengxiao (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Berglund, Emelie (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Rajakumar, T (author)
- Ji, AL (author)
- Khavari, PA (author)
- Tarish, F (author)
- Tanoglidi, A (author)
- Colling, R (author)
- Mirtti, T (author)
- Hamdy, FC (author)
- Woodcock, DJ (author)
- Mills, IG (author)
- Lamb, AD (author)
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- Univ Oxford, Nuffield Dept SurgicalSci, Oxford, England Genteknologi (creator_code:org_t)
- 2022-08-10
- 2022
- English.
- In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7922, s. 360-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer1. Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics2 to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Ekonomi och näringsliv -- Företagsekonomi (hsv//swe)
- SOCIAL SCIENCES -- Economics and Business -- Business Administration (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Erickson, A
- He, Mengxiao
- Berglund, Emelie
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- Mirzazadeh, Reza
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- Mirtti, T
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- Helleday, T
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- Karolinska Institutet
- Royal Institute of Technology
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