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Sökning: WFRF:(Hamm Alfons)

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1.
  • Globisch, Jutta, et al. (författare)
  • Fear appears fast : Temporal course of startle reflex potentiation in animal fearful subjects
  • 1999
  • Ingår i: Psychophysiology. - 0048-5772 .- 1469-8986. ; 36:1, s. 66-75
  • Tidskriftsartikel (refereegranskat)abstract
    • The temporal course of startle reflex modulation and autonomic response patterns to fear‐relevant and fear‐irrelevant pictures in subjects with high and low levels of animal fear was investigated. Thirty‐eight high‐fear and 48 low‐fear volunteers viewed photos of snakes and spiders and pictures of neutral and pleasant content. The slides were presented for 6 s or for only 150 ms, depending on the group. Acoustic startle probes were presented at five different times after slide onset. Relative potentiation of the startle responses started 300 ms after onset of snake/spider pictures in fearful subjects. This fear‐potentiated startle effect was maintained for the later probe times and was identical in the 150‐ms condition. Fear‐relevant pictures also prompted a sympathetically dominated autonomic response profile in fearful persons. These data support the idea that fear can be activated very rapidly, requiring only minimal stimulus input.
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2.
  • Schiele, Miriam A., et al. (författare)
  • Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders : A meta-analysis
  • 2021
  • Ingår i: European Neuropsychopharmacology. - : Elsevier. - 0924-977X .- 1873-7862. ; 44, s. 105-120
  • Tidskriftsartikel (refereegranskat)abstract
    • There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
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